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Q67LG6

- UPPP_SYMTH

UniProt

Q67LG6 - UPPP_SYMTH

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSTHE292459:GJMM-2576-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:STH2495
    OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
    Taxonomic identifieri292459 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
    ProteomesiUP000000417: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Undecaprenyl-diphosphatasePRO_0000151222Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi292459.STH2495.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalUniRule annotationAdd
    BLAST
    Transmembranei52 – 7221HelicalUniRule annotationAdd
    BLAST
    Transmembranei96 – 11621HelicalUniRule annotationAdd
    BLAST
    Transmembranei122 – 14221HelicalUniRule annotationAdd
    BLAST
    Transmembranei154 – 17421HelicalUniRule annotationAdd
    BLAST
    Transmembranei197 – 21721HelicalUniRule annotationAdd
    BLAST
    Transmembranei225 – 24521HelicalUniRule annotationAdd
    BLAST
    Transmembranei253 – 27321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiIEGPFRD.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q67LG6-1 [UniParc]FASTAAdd to Basket

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    MLFIGKTTEG FPVTVLQAVI LGIVQGLAEF LPISSSAHLI LVPWFLGWSP    50
    SGLAFDLALH VGTLIAVTIY FWRDLLNLAV EGLTKGMKTP TGRLAWGIVL 100
    GTVPGAIFGL LMEDVVEAVF RQSILTIALL LAVVGVILYL ADRFGPKRRS 150
    LEEIRVSDVI WIGLAQALAV IPGVSRSGAT ITAGLALGLK RETAAKVSFL 200
    LGWPIILGGA VLVIPDADPA MFTPSFFAGV AAAAVSGYAV IAALLRYLQR 250
    GSYLVFAWYR GLVAAVTVAL LLARGM 276
    Length:276
    Mass (Da):29,199
    Last modified:October 11, 2004 - v1
    Checksum:i6C1B484FCF3E1EC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006840 Genomic DNA. Translation: BAD41480.1.
    RefSeqiYP_076324.1. NC_006177.1.

    Genome annotation databases

    EnsemblBacteriaiBAD41480; BAD41480; STH2495.
    GeneIDi2982447.
    KEGGisth:STH2495.
    PATRICi23783162. VBISymThe116959_2489.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006840 Genomic DNA. Translation: BAD41480.1 .
    RefSeqi YP_076324.1. NC_006177.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292459.STH2495.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD41480 ; BAD41480 ; STH2495 .
    GeneIDi 2982447.
    KEGGi sth:STH2495.
    PATRICi 23783162. VBISymThe116959_2489.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi IEGPFRD.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci STHE292459:GJMM-2576-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
      Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
      Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: T / IAM 14863.

    Entry informationi

    Entry nameiUPPP_SYMTH
    AccessioniPrimary (citable) accession number: Q67LG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3