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Q67LB8

- MDH_SYMTH

UniProt

Q67LB8 - MDH_SYMTH

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADUniRule annotation
Binding sitei85 – 851SubstrateUniRule annotation
Binding sitei91 – 911SubstrateUniRule annotation
Binding sitei98 – 981NADUniRule annotation
Binding sitei123 – 1231SubstrateUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Active sitei178 – 1781Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADUniRule annotation
Nucleotide bindingi121 – 1233NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-2624-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:STH2543
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
ProteomesiUP000000417: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Malate dehydrogenasePRO_0000113474Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292459.STH2543.

Structurei

3D structure databases

ProteinModelPortaliQ67LB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q67LB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRKKIAIVG SGFTGQGTAL FAAARDLGDI VLVDLPAREN YAKGVALDMM
60 70 80 90 100
EAMPVYGSDT RLVGTSDYAE IAGADVVVIT AGVPRKPGMS REDLVNTNAG
110 120 130 140 150
IVKDVAEKVA RYAPDSVIIV LTNPVDSMTY VALKASGFPK NRVIGQSGVL
160 170 180 190 200
DTARFRTFLA NAIGCSFQDV VGCVLGGHGD DMVPLVRYTS AGGIPVEKLL
210 220 230 240 250
PKETIDAIVE RTRKGGGEIV NLMGTSAGYA PGMALVEMID AILNDRKRIL
260 270 280 290 300
PSIAYLEGEY GYTDMCLGVM TVLGGGGLEK VIELDLTDEE KVALDKGAQG
310
VRNLIEMLKA GILAQ
Length:315
Mass (Da):33,229
Last modified:October 11, 2004 - v1
Checksum:i8277B3A4A25CDF1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD41528.1.
RefSeqiWP_011196666.1. NC_006177.1.
YP_076372.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD41528; BAD41528; STH2543.
GeneIDi2979396.
KEGGisth:STH2543.
PATRICi23783256. VBISymThe116959_2536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD41528.1 .
RefSeqi WP_011196666.1. NC_006177.1.
YP_076372.1. NC_006177.1.

3D structure databases

ProteinModelPortali Q67LB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292459.STH2543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD41528 ; BAD41528 ; STH2543 .
GeneIDi 2979396.
KEGGi sth:STH2543.
PATRICi 23783256. VBISymThe116959_2536.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci STHE292459:GJMM-2624-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiMDH_SYMTH
AccessioniPrimary (citable) accession number: Q67LB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3