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Q67KZ3 (GLUQ_SYMTH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamyl-Q tRNA(Asp) synthetase
Short name=Glu-Q-RSs
EC=6.1.1.-
Gene names
Name:gluQ
Ordered Locus Names:STH2668
OrganismSymbiobacterium thermophilum [Complete proteome] [HAMAP]
Taxonomic identifier2734 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon By similarity. HAMAP MF_01428

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01428

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Glutamyl-Q tRNA(Asp) synthetase HAMAP MF_01428
PRO_0000208328

Regions

Region5 – 95Glutamate binding By similarity
Motif8 – 1811"HIGH" region HAMAP MF_01428
Motif249 – 2535"KMSKS" region HAMAP MF_01428

Sites

Metal binding1051Zinc By similarity
Metal binding1071Zinc By similarity
Metal binding1291Zinc By similarity
Metal binding1331Zinc By similarity
Binding site411Glutamate By similarity
Binding site1931Glutamate By similarity
Binding site2111Glutamate By similarity
Binding site2521ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q67KZ3 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: CDB3D7538A8CF87C

FASTA32334,743
        10         20         30         40         50         60 
MLCGRFAPTP SGALHLGNAR TALLAWLHAR RAGGRFILRI EDIDRARSRP HLAEQAIADL 

        70         80         90        100        110        120 
RWLGLDWDEG PDVGGPHGPY CQSEREELYR DALARLQAEG RLYPCYCSRA QLMAIASAPH 

       130        140        150        160        170        180 
GLTSEGPAYP GTCRRLTPEE RRAREADGKT PSLRFALPDE EIAFTDLIAG PQRFPPGAGG 

       190        200        210        220        230        240 
DFVVLRADGV IGYQLAVVVD DALMGVTHVL RGGDLLDSTP RQILLYRALG RPVPAFGHLP 

       250        260        270        280        290        300 
LLLGPDGARL AKRHGAVTLA GIRAAGTSPE TVVGHLAYLS GLVDQPEPVR PEELIPVFDL 

       310        320 
ARIPREPVRI PAETIAALSG GTA

« Hide

References

[1]"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
Nucleic Acids Res. 32:4937-4944(2004) [PubMed: 15383646] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T / IAM 14863.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006840 Genomic DNA. Translation: BAD41653.1.
RefSeqYP_076497.1. NC_006177.1.

3D structure databases

ProteinModelPortalQ67KZ3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2980023.
GenomeReviewsGene locus STH2668 in contig AP006840_GR.
KEGGsth:STH2668.
NMPDRfig|292459.1.peg.2556.
PATRIC23783512. VBISymThe116959_2661.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628189.
OMALAPPRFA.
ProtClustDBPRK05710.

Enzyme and pathway databases

BioCycSTHE292459:STH2668-MONOMER.

Family and domain databases

HAMAPMF_01428. Glu_Q_tRNA_synth.
[Tree]
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR022380. Glu-Q_TRNA(Asp)_Synthase.
IPR004527. Glu-tRNA-synth_Ib_bac/mito.
IPR000924. Glu/Gln-tRNA-synth_Ib.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:1.10.1160.10. Glu/Gln-tRNA-synth_Ic_a-bdl. 1 hit.
G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KOK01885.
PANTHERPTHR10119. Glu_tRNA-synt_1c. 1 hit.
PTHR10119:SF1. PTHR10119:SF1. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
TIGRFAMsTIGR03838. Queuosine_YadB. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLUQ_SYMTH
AccessionPrimary (citable) accession number: Q67KZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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