Q67KM3 (GSA_SYMTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	STH2790

Organism

Symbiobacterium thermophilum (strain T / IAM 14863) [Complete proteome] [HAMAP]

Taxonomic identifier

292459 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales incertae sedis › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium › Symbiobacterium thermophilum

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_0000243626
Amino acid modifications
	Modified residue	270	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q67KM3 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: EB1021B9102E297C	FASTA	433	45,940
	10 20 30 40 50 60 MTARYERSAA LYERAVARIV GGVNSPARSF KSVGGGAPVF MARGQGPYLY DVDGNRYIDY 70 80 90 100 110 120 IGAFGAGMFG HGHPELVAAV ARAAEGGTIY GTPNPWEVEL AERIHQALPS MERIRFVTTG 130 140 150 160 170 180 TEAVMSAVRV ARAFTGRPKI IKMEGCYHGH SDFALIAAGS GPSQLGTPDS AGVTEGVAQD 190 200 210 220 230 240 VITVPYNDLD SLGEALDVWG PQVAAVLVEP IVGNFGVAMP KPGYLEGVKR LAHAHGALLI 250 260 270 280 290 300 FDEVITGFRV AYGGAQTLLG IEPDLTTLGK IIGGGLPLAA YGGRAEIMDW VAPLGPAYQA 310 320 330 340 350 360 GTLAGNPLCM QVALTGLEIL SRPGVYERLD ADAAYLADGL VRSARSHGHT VQLGRAGSMF 370 380 390 400 410 420 TLFFCDEPVV DYRTAQRSDP AKFAAMFRGL LDRGIALAPS RFEAWMLTVQ HTRADLEETL 430 QIADEVFAQM AGQ

References

[1]

"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism." Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T. Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: T / IAM 14863.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006840 Genomic DNA. Translation: BAD41775.1.
RefSeq	YP_076619.1. NC_006177.1.
3D structure databases
ProteinModelPortal	Q67KM3.
ModBase	Search...
Protein-protein interaction databases
STRING	292459.STH2790.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD41775; BAD41775; STH2790.
GeneID	2982017.
KEGG	sth:STH2790.
PATRIC	23783759. VBISymThe116959_2770.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	ETTEIAW.
ProtClustDB	PRK12389.
Enzyme and pathway databases
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_SYMTH

Accession

Primary (citable) accession number: Q67KM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program