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Q67KH6

- HISX_SYMTH

UniProt

Q67KH6 - HISX_SYMTH

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Protein
Histidinol dehydrogenase
Gene
hisD, STH2837
Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251NAD By similarity
Binding sitei187 – 1871NAD By similarity
Binding sitei210 – 2101NAD By similarity
Binding sitei233 – 2331Substrate By similarity
Metal bindingi255 – 2551Zinc By similarity
Binding sitei255 – 2551Substrate By similarity
Metal bindingi258 – 2581Zinc By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei323 – 3231Proton acceptor By similarity
Active sitei324 – 3241Proton acceptor By similarity
Binding sitei324 – 3241Substrate By similarity
Metal bindingi357 – 3571Zinc By similarity
Binding sitei357 – 3571Substrate By similarity
Binding sitei411 – 4111Substrate By similarity
Metal bindingi416 – 4161Zinc By similarity
Binding sitei416 – 4161Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-2938-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:STH2837
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
ProteomesiUP000000417: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Histidinol dehydrogenaseUniRule annotation
PRO_0000135861Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292459.STH2837.

Structurei

3D structure databases

ProteinModelPortaliQ67KH6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67KH6-1 [UniParc]FASTAAdd to Basket

« Hide

MLKVWEPQAF LEFLNRRRTE FYPEIEAQVR AILERVRREG DGALYAFTRQ    50
FDGADLEATG LRVTEAEYRE AEAAVSAAFR AALQVAVENI AAFHRPQVPT 100
SWFTTRPDGT IVGQRVTPVD RAGVYVPGGS APLFSCLLMT AIPAVVAGVP 150
EVIVCTPPDR NGRIDPHMLV AARAAGVKDV YKVGGAQAIG AMAYGTATVP 200
RVDKIAGPGN YYVTLAKKLV FGPVGIDMLA GPTEVMAVDD GSVDAEWLAA 250
DLLSQAEHPN GMVILVTTAG PERIAAVGAA MARHTAALPR AETIRRSVAE 300
LGAALAVDTL EEAADLVNAV GPEHLEVGVA DPWAFLPLVR HAGSIFLGRW 350
TPEAMGDYIA GPSNVIPTEG TARYASPVCV ETFIKRSAVT CYSEAAFRAQ 400
APHAVRLALT EDLLAHAASM QIRLAKPDGE SPSEGREAG 439
Length:439
Mass (Da):46,628
Last modified:October 11, 2004 - v1
Checksum:i45D8E26BC3568EAA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD41822.1.
RefSeqiWP_011196956.1. NC_006177.1.
YP_076666.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD41822; BAD41822; STH2837.
GeneIDi2979878.
KEGGisth:STH2837.
PATRICi23783855. VBISymThe116959_2816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD41822.1 .
RefSeqi WP_011196956.1. NC_006177.1.
YP_076666.1. NC_006177.1.

3D structure databases

ProteinModelPortali Q67KH6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 292459.STH2837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD41822 ; BAD41822 ; STH2837 .
GeneIDi 2979878.
KEGGi sth:STH2837.
PATRICi 23783855. VBISymThe116959_2816.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci STHE292459:GJMM-2938-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiHISX_SYMTH
AccessioniPrimary (citable) accession number: Q67KH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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