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Q67KG3

- PUR9_SYMTH

UniProt

Q67KG3 - PUR9_SYMTH

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, STH2850
Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-2951-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:STH2850
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
ProteomesiUP000000417: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018976Add
BLAST

Proteomic databases

PRIDEiQ67KG3.

Interactioni

Protein-protein interaction databases

STRINGi292459.STH2850.

Structurei

3D structure databases

ProteinModelPortaliQ67KG3.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q67KG3-1 [UniParc]FASTAAdd to Basket

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MKRALISVYD KQGIVEFARG LADLGVEIIS TGGTYRTLQG AGIPVREVAE    50
VAGFPEILDG RVKSLQPQIH AGILAMRANP THMAQLAEHG IGLIDLVVVN 100
LYPFRETVAN PAVTLEEAIE KIDIGGPAMV RAAAKNYQDV GVVVNPARYP 150
AVLAELRETG DLSLPTRFSL MLEAFQHTAA YDGAIAGWMA TRGREIVATR 200
ALGETAPERP IGADPGPQKP AAPSPFPDVL SLTFTKVQEL RYGENPHQAA 250
AFYSDGSDGG TVIARAKQLH GKELSFNNIN DAHAALELVK EFEEPAAVAI 300
KHANPCGVAV APTIAEAFRK AYEADTVSIF GGIVALNRPC DRETAEALSK 350
IFLEIVIAPA FAPEALEVLT RKKNLRLLAV GPIDRNPPSG FDMKRVGGGL 400
LVQSWDAIAE DPVAWKPVTK AAPTPEQLRD LAFAMKVCKH VKSNAIVVAR 450
DGQTLGVGAG QMNRIDAARF ALRQAGEKAR GAVLASDAFF PFPDVVEAAG 500
EAGIAAIVQP GGSIRDEESI ARADELGLAM VFTGVRHFRH 540
Length:540
Mass (Da):57,507
Last modified:October 11, 2004 - v1
Checksum:iB01DBC29E903F631
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD41835.1.
RefSeqiWP_011196969.1. NC_006177.1.
YP_076679.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD41835; BAD41835; STH2850.
GeneIDi2980007.
KEGGisth:STH2850.
PATRICi23783881. VBISymThe116959_2829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006840 Genomic DNA. Translation: BAD41835.1 .
RefSeqi WP_011196969.1. NC_006177.1.
YP_076679.1. NC_006177.1.

3D structure databases

ProteinModelPortali Q67KG3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 292459.STH2850.

Proteomic databases

PRIDEi Q67KG3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD41835 ; BAD41835 ; STH2850 .
GeneIDi 2980007.
KEGGi sth:STH2850.
PATRICi 23783881. VBISymThe116959_2829.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci STHE292459:GJMM-2951-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiPUR9_SYMTH
AccessioniPrimary (citable) accession number: Q67KG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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