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Q67KG3

- PUR9_SYMTH

UniProt

Q67KG3 - PUR9_SYMTH

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-2951-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:STH2850
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XVIII. Incertae SedisSymbiobacterium
ProteomesiUP000000417: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Bifunctional purine biosynthesis protein PurHPRO_1000018976Add
BLAST

Proteomic databases

PRIDEiQ67KG3.

Interactioni

Protein-protein interaction databases

STRINGi292459.STH2850.

Structurei

3D structure databases

ProteinModelPortaliQ67KG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q67KG3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRALISVYD KQGIVEFARG LADLGVEIIS TGGTYRTLQG AGIPVREVAE
60 70 80 90 100
VAGFPEILDG RVKSLQPQIH AGILAMRANP THMAQLAEHG IGLIDLVVVN
110 120 130 140 150
LYPFRETVAN PAVTLEEAIE KIDIGGPAMV RAAAKNYQDV GVVVNPARYP
160 170 180 190 200
AVLAELRETG DLSLPTRFSL MLEAFQHTAA YDGAIAGWMA TRGREIVATR
210 220 230 240 250
ALGETAPERP IGADPGPQKP AAPSPFPDVL SLTFTKVQEL RYGENPHQAA
260 270 280 290 300
AFYSDGSDGG TVIARAKQLH GKELSFNNIN DAHAALELVK EFEEPAAVAI
310 320 330 340 350
KHANPCGVAV APTIAEAFRK AYEADTVSIF GGIVALNRPC DRETAEALSK
360 370 380 390 400
IFLEIVIAPA FAPEALEVLT RKKNLRLLAV GPIDRNPPSG FDMKRVGGGL
410 420 430 440 450
LVQSWDAIAE DPVAWKPVTK AAPTPEQLRD LAFAMKVCKH VKSNAIVVAR
460 470 480 490 500
DGQTLGVGAG QMNRIDAARF ALRQAGEKAR GAVLASDAFF PFPDVVEAAG
510 520 530 540
EAGIAAIVQP GGSIRDEESI ARADELGLAM VFTGVRHFRH
Length:540
Mass (Da):57,507
Last modified:October 11, 2004 - v1
Checksum:iB01DBC29E903F631
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD41835.1.
RefSeqiWP_011196969.1. NC_006177.1.
YP_076679.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD41835; BAD41835; STH2850.
GeneIDi2980007.
KEGGisth:STH2850.
PATRICi23783881. VBISymThe116959_2829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD41835.1 .
RefSeqi WP_011196969.1. NC_006177.1.
YP_076679.1. NC_006177.1.

3D structure databases

ProteinModelPortali Q67KG3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292459.STH2850.

Proteomic databases

PRIDEi Q67KG3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD41835 ; BAD41835 ; STH2850 .
GeneIDi 2980007.
KEGGi sth:STH2850.
PATRICi 23783881. VBISymThe116959_2829.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci STHE292459:GJMM-2951-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
    Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
    Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: T / IAM 14863.

Entry informationi

Entry nameiPUR9_SYMTH
AccessioniPrimary (citable) accession number: Q67KG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3