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Q67KG0 (PUR5_SYMTH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:STH2853
OrganismSymbiobacterium thermophilum (strain T / IAM 14863) [Complete proteome] [HAMAP]
Taxonomic identifier292459 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales Family XVIII. Incertae Sedis › Symbiobacterium ›

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_0000258420

Sequences

Sequence LengthMass (Da)Tools
Q67KG0 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: F54688ECDB4AEF3F

FASTA35337,409
        10         20         30         40         50         60 
MTEKGLTYAD AGVNRERHYE LVRRIAAHTA RTLRRPGTLG NIGAFGGLFQ LDPARYPEPV 

        70         80         90        100        110        120 
LVSGTDGVGT KLRLAFLSGR HDTVGIDLVA MSVNDILCQG AEPLFFLDYI GIGQKDLAVL 

       130        140        150        160        170        180 
EQVVKGIADG CLQAGCALIG GETAELPGMY PPGEYDLAGF AVGIVNRDRL LTGEKVAPGD 

       190        200        210        220        230        240 
ALVGLASSGL HANGYSLARR VLLKVDGGAF DLDDRPPELG GRTVLEVMLT PTRIYVRTVL 

       250        260        270        280        290        300 
RLLARFDVHG IANITGGGLH ENIPRMLPEG TAAVLRRGAW KEPPVFDLIR RLGPVAQAEM 

       310        320        330        340        350 
EATFNLGLGM VLAVPADQAE AVAAAARELG EEAWVVGEVA AAEPGGPRVV VRR

« Hide

References

[1]"Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism."
Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K., Ikeda H., Hattori M., Beppu T.
Nucleic Acids Res. 32:4937-4944(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: T / IAM 14863.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006840 Genomic DNA. Translation: BAD41838.1.
RefSeqYP_076682.1. NC_006177.1.

3D structure databases

HSSPHSSP built from PDB template 1CLI based on UniProtKB P08178.
ProteinModelPortalQ67KG0.
SMRQ67KG0. Positions 20-352.
ModBaseSearch...

Protein-protein interaction databases

STRING292459.STH2853.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD41838; BAD41838; STH2853.
GeneID2980448.
KEGGsth:STH2853.
PATRIC23783887. VBISymThe116959_2832.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0150.
HOGENOMHOG000229090.
KOK01933.
OMAIDMIAMN.
ProtClustDBPRK05385.

Enzyme and pathway databases

UniPathwayUPA00074; UER00129.

Family and domain databases

HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 1 hit.
SSF55326. PurM_N-like. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_SYMTH
AccessionPrimary (citable) accession number: Q67KG0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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