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Protein

Ribonuclease H

Gene

rnhA

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Magnesium 1UniRule annotation
Metal bindingi9 – 91Magnesium 2UniRule annotation
Metal bindingi47 – 471Magnesium 1UniRule annotation
Metal bindingi69 – 691Magnesium 1UniRule annotation
Metal bindingi134 – 1341Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-3021-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HUniRule annotation
Gene namesi
Name:rnhAUniRule annotation
Ordered Locus Names:STH2922
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSymbiobacteriaceaeSymbiobacterium
Proteomesi
  • UP000000417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Ribonuclease HPRO_0000332680Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi292459.STH2922.

Structurei

3D structure databases

ProteinModelPortaliQ67K93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 142142RNase HUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RNase H family.UniRule annotation
Contains 1 RNase H domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UMW. Bacteria.
COG0328. LUCA.
HOGENOMiHOG000040465.
KOiK03469.
OMAiLVTDSQY.
OrthoDBiPOG091H04XT.

Family and domain databases

CDDicd09278. RNase_HI_prokaryote_like. 1 hit.
Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00042. RNase_H. 1 hit.
InterProiIPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR022892. RNaseHI.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50879. RNASE_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67K93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREVIIYTDG ACSGNPGPGG WGAVLLYGSH RKELSGFHPH TTNNRMEIQA
60 70 80 90 100
AIEALRALKY PCKVKLYSDS AYLVNAFRQN WLRTWQRNGW VNSRKQPVEN
110 120 130 140
QDLWQELLEA ARPHQVEWLK VQGHADVAEN NRCDELARAA IAAGTQG
Length:147
Mass (Da):16,584
Last modified:October 11, 2004 - v1
Checksum:i221D1CCA7D5800A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD41905.1.
RefSeqiWP_011197039.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD41905; BAD41905; STH2922.
KEGGisth:STH2922.
PATRICi23784027. VBISymThe116959_2902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD41905.1.
RefSeqiWP_011197039.1. NC_006177.1.

3D structure databases

ProteinModelPortaliQ67K93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi292459.STH2922.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD41905; BAD41905; STH2922.
KEGGisth:STH2922.
PATRICi23784027. VBISymThe116959_2902.

Phylogenomic databases

eggNOGiENOG4108UMW. Bacteria.
COG0328. LUCA.
HOGENOMiHOG000040465.
KOiK03469.
OMAiLVTDSQY.
OrthoDBiPOG091H04XT.

Enzyme and pathway databases

BioCyciSTHE292459:GJMM-3021-MONOMER.

Family and domain databases

CDDicd09278. RNase_HI_prokaryote_like. 1 hit.
Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00042. RNase_H. 1 hit.
InterProiIPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR022892. RNaseHI.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50879. RNASE_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNH_SYMTH
AccessioniPrimary (citable) accession number: Q67K93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.