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Protein

Protein-arginine kinase

Gene

mcsB

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of arginine residues in proteins.UniRule annotation

Catalytic activityi

ATP + a [protein]-L-arginine = ADP + a [protein]-N(omega)-phospho-L-arginine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93ATPUniRule annotation1
Binding sitei127ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 31ATPUniRule annotation5
Nucleotide bindingi178 – 182ATPUniRule annotation5
Nucleotide bindingi209 – 214ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine kinaseUniRule annotation (EC:2.7.14.1UniRule annotation)
Gene namesi
Name:mcsBUniRule annotation
Ordered Locus Names:STH3134
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSymbiobacteriaceaeSymbiobacterium
Proteomesi
  • UP000000417 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002120381 – 353Protein-arginine kinaseAdd BLAST353

Interactioni

Protein-protein interaction databases

STRINGi292459.STH3134.

Structurei

3D structure databases

ProteinModelPortaliQ67JN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 256Phosphagen kinase C-terminalUniRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.UniRule annotation
Contains 1 phosphagen kinase C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiRIQCILP.
OrthoDBiPOG091H027W.

Family and domain databases

CDDicd07930. bacterial_phosphagen_kinase. 1 hit.
Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase. 1 hit.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67JN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWNELVSRA ESRWMEGTGP HADIVLSSRI RLARNLDDLP FPQRMSEPDT
60 70 80 90 100
ERLLQAAEAG VREINLVGFP SRVELYRLAD TTPLDRQILV EKHLISPQQS
110 120 130 140 150
KEVMAKAVAI SEDEAISIMV NEEDHLRIQV LASGLQLQEA WRVASQVDDA
160 170 180 190 200
LEQRLQFAFD EQLGYLTACP TNVGTGLRAS VMMHLPALVL TQQAGRLFHN
210 220 230 240 250
LSQLGLVVRG LYGEGTEAAG QIFQISNQTS LGKAEEEIIA NLEAIARTVI
260 270 280 290 300
DTEEQARRHL YGEMRLQIED RVSRAYGILT TARMISSEEA MRLLSDVRLG
310 320 330 340 350
VALGVVPKID YRILNELLVA MQPACLQRQA GRELNPLERD VRRAALIRAR

LSA
Length:353
Mass (Da):39,405
Last modified:October 11, 2004 - v1
Checksum:i33E19F14BC005834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD42116.1.

Genome annotation databases

EnsemblBacteriaiBAD42116; BAD42116; STH3134.
KEGGisth:STH3134.
PATRICi23784459. VBISymThe116959_3114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD42116.1.

3D structure databases

ProteinModelPortaliQ67JN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi292459.STH3134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD42116; BAD42116; STH3134.
KEGGisth:STH3134.
PATRICi23784459. VBISymThe116959_3114.

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiRIQCILP.
OrthoDBiPOG091H027W.

Family and domain databases

CDDicd07930. bacterial_phosphagen_kinase. 1 hit.
Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase. 1 hit.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCSB_SYMTH
AccessioniPrimary (citable) accession number: Q67JN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.