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Protein

Type III pantothenate kinase 2

Gene

coaX2

Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase 2 (coaX2), Type III pantothenate kinase 1 (coaX1)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100SubstrateUniRule annotation1
Active sitei109Proton acceptorUniRule annotation1
Metal bindingi129Monovalent cationUniRule annotation1
Binding sitei132ATPUniRule annotation1
Binding sitei184SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 13ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinase 2UniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-III 2UniRule annotation
Pantothenic acid kinase 2UniRule annotation
Gene namesi
Name:coaX2UniRule annotation
Ordered Locus Names:STH3184
OrganismiSymbiobacterium thermophilum (strain T / IAM 14863)
Taxonomic identifieri292459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSymbiobacteriaceaeSymbiobacterium
Proteomesi
  • UP000000417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002675921 – 264Type III pantothenate kinase 2Add BLAST264

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi292459.STH3184.

Structurei

3D structure databases

ProteinModelPortaliQ67JI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 110Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGM. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiLENHYAR.
OrthoDBiPOG091H01V7.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.

Sequencei

Sequence statusi: Complete.

Q67JI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTIDVGNT FTVAGVFEGQ NLLAEWTVTT DPNRTMDEYG MLFTQLMARA
60 70 80 90 100
GFSSGQVTAV AIASSVPPLV PTLEWMCQKY FNLKPLVVGP GVRTGMMIRY
110 120 130 140 150
DNPREVGADR IVGAVAAFDK YGGPLIVVDF STAIILDAIS ARGEYLGGVI
160 170 180 190 200
APGIVVSADA LFQFAAKLPR VELVRPPRAL ARNTVHAMQS GIIFGFASLV
210 220 230 240 250
DDLVERMMAE LDPEGKGCKV VATGEQAELL AGECATIQYC DPSLTLTGLR
260
IIYERHQAHA RGGR
Length:264
Mass (Da):28,366
Last modified:October 11, 2004 - v1
Checksum:i838D30F2A560E92D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD42166.1.
RefSeqiWP_011197297.1. NC_006177.1.

Genome annotation databases

EnsemblBacteriaiBAD42166; BAD42166; STH3184.
KEGGisth:STH3184.
PATRICi23784569. VBISymThe116959_3168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006840 Genomic DNA. Translation: BAD42166.1.
RefSeqiWP_011197297.1. NC_006177.1.

3D structure databases

ProteinModelPortaliQ67JI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi292459.STH3184.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD42166; BAD42166; STH3184.
KEGGisth:STH3184.
PATRICi23784569. VBISymThe116959_3168.

Phylogenomic databases

eggNOGiENOG4105CGM. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066025.
KOiK03525.
OMAiLENHYAR.
OrthoDBiPOG091H01V7.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00671. baf. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAX2_SYMTH
AccessioniPrimary (citable) accession number: Q67JI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.