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Q67IX6

- PDI14_ORYSJ

UniProt

Q67IX6 - PDI14_ORYSJ

Protein

Protein disulfide isomerase-like 1-4

Gene

PDIL1-4

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis By similarity.By similarity

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei102 – 1021NucleophileBy similarity
    Active sitei105 – 1051NucleophileBy similarity
    Sitei166 – 1661Lowers pKa of C-terminal Cys of first active siteBy similarity
    Active sitei444 – 4441NucleophileBy similarity
    Sitei445 – 4451Contributes to redox potential valueBy similarity
    Sitei446 – 4461Contributes to redox potential valueBy similarity
    Active sitei447 – 4471NucleophileBy similarity
    Sitei509 – 5091Lowers pKa of C-terminal Cys of second active siteBy similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. response to endoplasmic reticulum stress Source: EnsemblPlants/Gramene
    3. response to oxidative stress Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide isomerase-like 1-4 (EC:5.3.4.1)
    Short name:
    OsPDIL1-4
    Alternative name(s):
    Protein disulfide isomerase-like 2-1
    Short name:
    OsPDIL2-1
    Gene namesi
    Name:PDIL1-4
    Synonyms:PDIL2-1
    Ordered Locus Names:Os02g0100100, LOC_Os02g01010
    ORF Names:OsJ_04977, OSJNOa183H18.2
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 2

    Organism-specific databases

    GrameneiQ67IX6.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: EnsemblPlants/Gramene
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. mitochondrion Source: EnsemblPlants/Gramene
    4. vacuolar membrane Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 563541Protein disulfide isomerase-like 1-4PRO_0000400031Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi102 ↔ 105Redox-activePROSITE-ProRule annotation
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi444 ↔ 447Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ67IX6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 180135Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini394 – 523130Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi560 – 5634Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    KOiK09580.
    OMAiYFGISGT.

    Family and domain databases

    Gene3Di3.40.30.10. 4 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q67IX6-1 [UniParc]FASTAAdd to Basket

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    MRSRSLLLVA LATLLLHASA SASDDDLDYL IDNADDIPAN DPDGWLQEGS    50
    PDDDDDDDLF HHGQAQDHPI DETHVFLLSA ANFSDFLASH RHVMVEFYAP 100
    WCAHCQALAP DYAAAAADLS PLAHQVALAK VDATEDTDLA QKYDVQGFPT 150
    ILFFIDGVPK DYNGARTKEA IVSWVNKKLA PGVQNITTVD EAEKILTGED 200
    KAILAVLDSL SGAHSDEIAA ASRLEDAINF YQTSNPDVAK LFHLDPAAKR 250
    PSLVLLKKQE EEKLTFYDGP FKASAIADFV SANKLPLVNT LTQETAPSIF 300
    DNPIKKQILL FVVANESSKF LPIFKEASKS FKGKLLFVFV ERDNEEVGEP 350
    VANYFGITGQ ETTVLAYTGN EDARNFFLDG EISVENIKRF AEDFLEEKLT 400
    PFYKSEPVPE SNEGDVKIVV GKNLDQIVLD ESKDALLEIY APWCGHCQEL 450
    EPTYNKLGKH LRGIDSLVIA KMDGTANEHP RAKPDGFPTI LFYPAGKKSF 500
    EPITFEGDRT VVEMYKFIKK HASIPFKLKR PDSSATKTEK DQSTASTNLR 550
    GERSSGTNFK DEL 563
    Length:563
    Mass (Da):62,253
    Last modified:October 11, 2004 - v1
    Checksum:iF6862C4A2C65491F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008208 Genomic DNA. Translation: BAF07493.1.
    AP006851 Genomic DNA. Translation: BAD38565.1.
    CM000139 Genomic DNA. Translation: EEE56114.1.
    AK071514 mRNA. Translation: BAG92533.1.
    RefSeqiNP_001045579.1. NM_001052114.1.
    UniGeneiOs.13477.

    Genome annotation databases

    EnsemblPlantsiOS02T0100100-01; OS02T0100100-01; OS02G0100100.
    GeneIDi4327971.
    KEGGiosa:4327971.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008208 Genomic DNA. Translation: BAF07493.1 .
    AP006851 Genomic DNA. Translation: BAD38565.1 .
    CM000139 Genomic DNA. Translation: EEE56114.1 .
    AK071514 mRNA. Translation: BAG92533.1 .
    RefSeqi NP_001045579.1. NM_001052114.1.
    UniGenei Os.13477.

    3D structure databases

    ProteinModelPortali Q67IX6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS02T0100100-01 ; OS02T0100100-01 ; OS02G0100100 .
    GeneIDi 4327971.
    KEGGi osa:4327971.

    Organism-specific databases

    Gramenei Q67IX6.

    Phylogenomic databases

    eggNOGi COG0526.
    KOi K09580.
    OMAi YFGISGT.

    Family and domain databases

    Gene3Di 3.40.30.10. 4 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    3. "Sequencing and characterization of telomere and subtelomere regions on rice chromosomes 1S, 2S, 2L, 6L, 7S, 7L and 8S."
      Mizuno H., Wu J., Kanamori H., Fujisawa M., Namiki N., Saji S., Katagiri S., Katayose Y., Sasaki T., Matsumoto T.
      Plant J. 46:206-217(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.
    6. "Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
      Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
      Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    7. "The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
      d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
      BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPDI14_ORYSJ
    AccessioniPrimary (citable) accession number: Q67IX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2010
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3