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Q67FW5 (B3GNL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1

Short name=BGnT-like protein 1
Short name=Beta1,3-N-acetylglucosaminyltransferase-like protein 1
Short name=Beta3Gn-T-like protein 1
Short name=Beta3GnTL1
EC=2.4.1.-
Alternative name(s):
Beta-1,3-N-acetylglucosaminyltransferase 8
Short name=BGnT-8
Short name=Beta-1,3-Gn-T8
Short name=Beta3Gn-T8
Gene names
Name:B3GNTL1
Synonyms:B3GNT8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative glycosyltransferase Potential.

Tissue specificity

Widely expressed. Highly expressed in adult pancreas. Expressed at moderate level in kidney, spleen, thymus, prostate, testis and ovary. Weakly expressed in small intestine, colon, peripheral blood leukocyte and liver. Ref.1

Sequence similarities

Belongs to the glycosyltransferase 2 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functiontransferase activity, transferring glycosyl groups

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1
PRO_0000289220

Natural variations

Natural variant3411A → T.
Corresponds to variant rs7225887 [ dbSNP | Ensembl ].
VAR_032603

Experimental info

Sequence conflict131S → R in AAQ74775. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q67FW5 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 582F65C4C61E4BB6

FASTA36140,713
        10         20         30         40         50         60 
MSGAGVGGAS EESQAMQAHV SIILPVHNAE PWLDECLRSV LQQDFEGTME LSVFNDASKD 

        70         80         90        100        110        120 
KSGAIIEKWR VKLEDSGVHV IIGGHDSPSP RGVGYAKNQA VAQSSGSYLC FLDSDDVMMP 

       130        140        150        160        170        180 
QRVRLQHEAA VQHPSSIIGC RVRRDPPNST ERYTRWINQL TPEQLLTQVF TSNGPTVIMP 

       190        200        210        220        230        240 
TWFCSRAWFS HVGPFNEGGQ GVPEDLLFFY EHLRKGGGVI RVDQSLLLYR HHPQAATHCV 

       250        260        270        280        290        300 
LETTIWTHRV RFLEEQALPR WAAFTIWNAG KQGRRLYRSL TAGSQRKVVA FCDVDENKIR 

       310        320        330        340        350        360 
KGFYCHEDSQ ERPKPRIPIL HFRAARPPFV ICVKLDLTGG AFEDNLRSLH LQEGQDFLHF 


S 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase."
Zheng H., Li Y., Ji C., Li J., Zhang J., Yin G., Xu J., Ye X., Wu M., Zou X., Gu S., Xie Y., Mao Y.
Mol. Biol. Rep. 31:171-175(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]Huang C.Q., Wu S.L., Zhou J.L.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-361.
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY304503 mRNA. Translation: AAQ74775.1.
AY634364 mRNA. Translation: AAT47555.1.
BC019623 mRNA. Translation: AAH19623.1.
RefSeqNP_001009905.1. NM_001009905.1.
UniGeneHs.607824.

3D structure databases

ProteinModelPortalQ67FW5.
SMRQ67FW5. Positions 20-116.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127003. 2 interactions.
IntActQ67FW5. 1 interaction.
MINTMINT-1413862.
STRING9606.ENSP00000319979.

Protein family/group databases

CAZyGT2. Glycosyltransferase Family 2.

PTM databases

PhosphoSiteQ67FW5.

Polymorphism databases

DMDM296434405.

Proteomic databases

PaxDbQ67FW5.
PRIDEQ67FW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320865; ENSP00000319979; ENSG00000175711.
GeneID146712.
KEGGhsa:146712.
UCSCuc002kgg.1. human.

Organism-specific databases

CTD146712.
GeneCardsGC17M080901.
HGNCHGNC:21727. B3GNTL1.
HPAHPA023585.
HPA024547.
MIM615337. gene.
neXtProtNX_Q67FW5.
PharmGKBPA134910219.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0463.
HOGENOMHOG000022151.
HOVERGENHBG097594.
InParanoidQ67FW5.
OMAFYSYEDS.
PhylomeDBQ67FW5.
TreeFamTF315120.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ67FW5.
BgeeQ67FW5.
CleanExHS_B3GNT8.
HS_B3GNTL1.
GenevestigatorQ67FW5.

Family and domain databases

InterProIPR001173. Glyco_trans_2-like.
[Graphical view]
PfamPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi146712.
NextBio85424.
PROQ67FW5.
SOURCESearch...

Entry information

Entry nameB3GNL_HUMAN
AccessionPrimary (citable) accession number: Q67FW5
Secondary accession number(s): Q6GV30, Q8WUT3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM