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Q67FW5

- B3GNL_HUMAN

UniProt

Q67FW5 - B3GNL_HUMAN

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Protein

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1

Gene

B3GNTL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Putative glycosyltransferase.Curated

GO - Molecular functioni

  1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 (EC:2.4.1.-)
Short name:
BGnT-like protein 1
Short name:
Beta1,3-N-acetylglucosaminyltransferase-like protein 1
Short name:
Beta3Gn-T-like protein 1
Short name:
Beta3GnTL1
Alternative name(s):
Beta-1,3-N-acetylglucosaminyltransferase 8
Short name:
BGnT-8
Short name:
Beta-1,3-Gn-T8
Short name:
Beta3Gn-T8
Gene namesi
Name:B3GNTL1
Synonyms:B3GNT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:21727. B3GNTL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1PRO_0000289220Add
BLAST

Proteomic databases

MaxQBiQ67FW5.
PaxDbiQ67FW5.
PRIDEiQ67FW5.

PTM databases

PhosphoSiteiQ67FW5.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in adult pancreas. Expressed at moderate level in kidney, spleen, thymus, prostate, testis and ovary. Weakly expressed in small intestine, colon, peripheral blood leukocyte and liver.1 Publication

Gene expression databases

BgeeiQ67FW5.
CleanExiHS_B3GNT8.
HS_B3GNTL1.
ExpressionAtlasiQ67FW5. baseline and differential.
GenevestigatoriQ67FW5.

Organism-specific databases

HPAiHPA023585.
HPA024547.

Interactioni

Protein-protein interaction databases

BioGridi127003. 2 interactions.
IntActiQ67FW5. 1 interaction.
MINTiMINT-1413862.
STRINGi9606.ENSP00000319979.

Structurei

3D structure databases

ProteinModelPortaliQ67FW5.
SMRiQ67FW5. Positions 20-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Phylogenomic databases

eggNOGiCOG0463.
GeneTreeiENSGT00390000006933.
HOGENOMiHOG000022151.
HOVERGENiHBG097594.
InParanoidiQ67FW5.
OMAiSECWLDE.
PhylomeDBiQ67FW5.
TreeFamiTF315120.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q67FW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGAGVGGAS EESQAMQAHV SIILPVHNAE PWLDECLRSV LQQDFEGTME
60 70 80 90 100
LSVFNDASKD KSGAIIEKWR VKLEDSGVHV IIGGHDSPSP RGVGYAKNQA
110 120 130 140 150
VAQSSGSYLC FLDSDDVMMP QRVRLQHEAA VQHPSSIIGC RVRRDPPNST
160 170 180 190 200
ERYTRWINQL TPEQLLTQVF TSNGPTVIMP TWFCSRAWFS HVGPFNEGGQ
210 220 230 240 250
GVPEDLLFFY EHLRKGGGVI RVDQSLLLYR HHPQAATHCV LETTIWTHRV
260 270 280 290 300
RFLEEQALPR WAAFTIWNAG KQGRRLYRSL TAGSQRKVVA FCDVDENKIR
310 320 330 340 350
KGFYCHEDSQ ERPKPRIPIL HFRAARPPFV ICVKLDLTGG AFEDNLRSLH
360
LQEGQDFLHF S
Length:361
Mass (Da):40,713
Last modified:May 18, 2010 - v2
Checksum:i582F65C4C61E4BB6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131S → R in AAQ74775. (PubMed:15560372)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti341 – 3411A → T.
Corresponds to variant rs7225887 [ dbSNP | Ensembl ].
VAR_032603

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY304503 mRNA. Translation: AAQ74775.1.
AY634364 mRNA. Translation: AAT47555.1.
BC019623 mRNA. Translation: AAH19623.1.
CCDSiCCDS32778.1.
RefSeqiNP_001009905.1. NM_001009905.1.
XP_006722335.1. XM_006722272.1.
UniGeneiHs.607824.

Genome annotation databases

EnsembliENST00000320865; ENSP00000319979; ENSG00000175711.
ENST00000621596; ENSP00000480784; ENSG00000277033.
GeneIDi146712.
KEGGihsa:146712.
UCSCiuc002kgg.1. human.

Polymorphism databases

DMDMi296434405.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY304503 mRNA. Translation: AAQ74775.1 .
AY634364 mRNA. Translation: AAT47555.1 .
BC019623 mRNA. Translation: AAH19623.1 .
CCDSi CCDS32778.1.
RefSeqi NP_001009905.1. NM_001009905.1.
XP_006722335.1. XM_006722272.1.
UniGenei Hs.607824.

3D structure databases

ProteinModelPortali Q67FW5.
SMRi Q67FW5. Positions 20-116.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127003. 2 interactions.
IntActi Q67FW5. 1 interaction.
MINTi MINT-1413862.
STRINGi 9606.ENSP00000319979.

Protein family/group databases

CAZyi GT2. Glycosyltransferase Family 2.

PTM databases

PhosphoSitei Q67FW5.

Polymorphism databases

DMDMi 296434405.

Proteomic databases

MaxQBi Q67FW5.
PaxDbi Q67FW5.
PRIDEi Q67FW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320865 ; ENSP00000319979 ; ENSG00000175711 .
ENST00000621596 ; ENSP00000480784 ; ENSG00000277033 .
GeneIDi 146712.
KEGGi hsa:146712.
UCSCi uc002kgg.1. human.

Organism-specific databases

CTDi 146712.
GeneCardsi GC17M080901.
HGNCi HGNC:21727. B3GNTL1.
HPAi HPA023585.
HPA024547.
MIMi 615337. gene.
neXtProti NX_Q67FW5.
PharmGKBi PA134910219.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0463.
GeneTreei ENSGT00390000006933.
HOGENOMi HOG000022151.
HOVERGENi HBG097594.
InParanoidi Q67FW5.
OMAi SECWLDE.
PhylomeDBi Q67FW5.
TreeFami TF315120.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.

Miscellaneous databases

ChiTaRSi B3GNTL1. human.
GenomeRNAii 146712.
NextBioi 85424.
PROi Q67FW5.
SOURCEi Search...

Gene expression databases

Bgeei Q67FW5.
CleanExi HS_B3GNT8.
HS_B3GNTL1.
ExpressionAtlasi Q67FW5. baseline and differential.
Genevestigatori Q67FW5.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00535. Glycos_transf_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase."
    Zheng H., Li Y., Ji C., Li J., Zhang J., Yin G., Xu J., Ye X., Wu M., Zou X., Gu S., Xie Y., Mao Y.
    Mol. Biol. Rep. 31:171-175(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Huang C.Q., Wu S.L., Zhou J.L.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-361.
    Tissue: Prostate.

Entry informationi

Entry nameiB3GNL_HUMAN
AccessioniPrimary (citable) accession number: Q67FW5
Secondary accession number(s): Q6GV30, Q8WUT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3