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Q67FW5

- B3GNL_HUMAN

UniProt

Q67FW5 - B3GNL_HUMAN

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Protein
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1
Gene
B3GNTL1, B3GNT8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative glycosyltransferase Reviewed prediction.

GO - Molecular functioni

  1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_115606. O-linked glycosylation of mucins.

    Protein family/group databases

    CAZyiGT2. Glycosyltransferase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 (EC:2.4.1.-)
    Short name:
    BGnT-like protein 1
    Short name:
    Beta1,3-N-acetylglucosaminyltransferase-like protein 1
    Short name:
    Beta3Gn-T-like protein 1
    Short name:
    Beta3GnTL1
    Alternative name(s):
    Beta-1,3-N-acetylglucosaminyltransferase 8
    Short name:
    BGnT-8
    Short name:
    Beta-1,3-Gn-T8
    Short name:
    Beta3Gn-T8
    Gene namesi
    Name:B3GNTL1
    Synonyms:B3GNT8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:21727. B3GNTL1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134910219.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1
    PRO_0000289220Add
    BLAST

    Proteomic databases

    MaxQBiQ67FW5.
    PaxDbiQ67FW5.
    PRIDEiQ67FW5.

    PTM databases

    PhosphoSiteiQ67FW5.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in adult pancreas. Expressed at moderate level in kidney, spleen, thymus, prostate, testis and ovary. Weakly expressed in small intestine, colon, peripheral blood leukocyte and liver.1 Publication

    Gene expression databases

    ArrayExpressiQ67FW5.
    BgeeiQ67FW5.
    CleanExiHS_B3GNT8.
    HS_B3GNTL1.
    GenevestigatoriQ67FW5.

    Organism-specific databases

    HPAiHPA023585.
    HPA024547.

    Interactioni

    Protein-protein interaction databases

    BioGridi127003. 2 interactions.
    IntActiQ67FW5. 1 interaction.
    MINTiMINT-1413862.
    STRINGi9606.ENSP00000319979.

    Structurei

    3D structure databases

    ProteinModelPortaliQ67FW5.
    SMRiQ67FW5. Positions 20-116.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0463.
    HOGENOMiHOG000022151.
    HOVERGENiHBG097594.
    InParanoidiQ67FW5.
    OMAiSECWLDE.
    PhylomeDBiQ67FW5.
    TreeFamiTF315120.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00535. Glycos_transf_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q67FW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGAGVGGAS EESQAMQAHV SIILPVHNAE PWLDECLRSV LQQDFEGTME    50
    LSVFNDASKD KSGAIIEKWR VKLEDSGVHV IIGGHDSPSP RGVGYAKNQA 100
    VAQSSGSYLC FLDSDDVMMP QRVRLQHEAA VQHPSSIIGC RVRRDPPNST 150
    ERYTRWINQL TPEQLLTQVF TSNGPTVIMP TWFCSRAWFS HVGPFNEGGQ 200
    GVPEDLLFFY EHLRKGGGVI RVDQSLLLYR HHPQAATHCV LETTIWTHRV 250
    RFLEEQALPR WAAFTIWNAG KQGRRLYRSL TAGSQRKVVA FCDVDENKIR 300
    KGFYCHEDSQ ERPKPRIPIL HFRAARPPFV ICVKLDLTGG AFEDNLRSLH 350
    LQEGQDFLHF S 361
    Length:361
    Mass (Da):40,713
    Last modified:May 18, 2010 - v2
    Checksum:i582F65C4C61E4BB6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti341 – 3411A → T.
    Corresponds to variant rs7225887 [ dbSNP | Ensembl ].
    VAR_032603

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131S → R in AAQ74775. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY304503 mRNA. Translation: AAQ74775.1.
    AY634364 mRNA. Translation: AAT47555.1.
    BC019623 mRNA. Translation: AAH19623.1.
    CCDSiCCDS32778.1.
    RefSeqiNP_001009905.1. NM_001009905.1.
    XP_006722335.1. XM_006722272.1.
    UniGeneiHs.607824.

    Genome annotation databases

    EnsembliENST00000320865; ENSP00000319979; ENSG00000175711.
    GeneIDi146712.
    KEGGihsa:146712.
    UCSCiuc002kgg.1. human.

    Polymorphism databases

    DMDMi296434405.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY304503 mRNA. Translation: AAQ74775.1 .
    AY634364 mRNA. Translation: AAT47555.1 .
    BC019623 mRNA. Translation: AAH19623.1 .
    CCDSi CCDS32778.1.
    RefSeqi NP_001009905.1. NM_001009905.1.
    XP_006722335.1. XM_006722272.1.
    UniGenei Hs.607824.

    3D structure databases

    ProteinModelPortali Q67FW5.
    SMRi Q67FW5. Positions 20-116.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 127003. 2 interactions.
    IntActi Q67FW5. 1 interaction.
    MINTi MINT-1413862.
    STRINGi 9606.ENSP00000319979.

    Protein family/group databases

    CAZyi GT2. Glycosyltransferase Family 2.

    PTM databases

    PhosphoSitei Q67FW5.

    Polymorphism databases

    DMDMi 296434405.

    Proteomic databases

    MaxQBi Q67FW5.
    PaxDbi Q67FW5.
    PRIDEi Q67FW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320865 ; ENSP00000319979 ; ENSG00000175711 .
    GeneIDi 146712.
    KEGGi hsa:146712.
    UCSCi uc002kgg.1. human.

    Organism-specific databases

    CTDi 146712.
    GeneCardsi GC17M080901.
    HGNCi HGNC:21727. B3GNTL1.
    HPAi HPA023585.
    HPA024547.
    MIMi 615337. gene.
    neXtProti NX_Q67FW5.
    PharmGKBi PA134910219.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0463.
    HOGENOMi HOG000022151.
    HOVERGENi HBG097594.
    InParanoidi Q67FW5.
    OMAi SECWLDE.
    PhylomeDBi Q67FW5.
    TreeFami TF315120.

    Enzyme and pathway databases

    Reactomei REACT_115606. O-linked glycosylation of mucins.

    Miscellaneous databases

    GenomeRNAii 146712.
    NextBioi 85424.
    PROi Q67FW5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q67FW5.
    Bgeei Q67FW5.
    CleanExi HS_B3GNT8.
    HS_B3GNTL1.
    Genevestigatori Q67FW5.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00535. Glycos_transf_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase."
      Zheng H., Li Y., Ji C., Li J., Zhang J., Yin G., Xu J., Ye X., Wu M., Zou X., Gu S., Xie Y., Mao Y.
      Mol. Biol. Rep. 31:171-175(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Huang C.Q., Wu S.L., Zhou J.L.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-361.
      Tissue: Prostate.

    Entry informationi

    Entry nameiB3GNL_HUMAN
    AccessioniPrimary (citable) accession number: Q67FW5
    Secondary accession number(s): Q6GV30, Q8WUT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 18, 2010
    Last modified: September 3, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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