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Protein

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1

Gene

B3GNTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative glycosyltransferase.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-913709. O-linked glycosylation of mucins.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 (EC:2.4.1.-)
Short name:
BGnT-like protein 1
Short name:
Beta1,3-N-acetylglucosaminyltransferase-like protein 1
Short name:
Beta3Gn-T-like protein 1
Short name:
Beta3GnTL1
Alternative name(s):
Beta-1,3-N-acetylglucosaminyltransferase 8
Short name:
BGnT-8
Short name:
Beta-1,3-Gn-T8
Short name:
Beta3Gn-T8
Gene namesi
Name:B3GNTL1
Synonyms:B3GNT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:21727. B3GNTL1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi146712.
OpenTargetsiENSG00000175711.
ENSG00000277033.
PharmGKBiPA134910219.

Polymorphism and mutation databases

BioMutaiB3GNTL1.
DMDMi296434405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892201 – 361UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1Add BLAST361

Proteomic databases

EPDiQ67FW5.
MaxQBiQ67FW5.
PaxDbiQ67FW5.
PeptideAtlasiQ67FW5.
PRIDEiQ67FW5.

PTM databases

iPTMnetiQ67FW5.
PhosphoSitePlusiQ67FW5.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in adult pancreas. Expressed at moderate level in kidney, spleen, thymus, prostate, testis and ovary. Weakly expressed in small intestine, colon, peripheral blood leukocyte and liver.1 Publication

Gene expression databases

BgeeiENSG00000175711.
CleanExiHS_B3GNT8.
HS_B3GNTL1.
ExpressionAtlasiQ67FW5. baseline and differential.
GenevisibleiQ67FW5. HS.

Organism-specific databases

HPAiHPA023585.
HPA024547.

Interactioni

Protein-protein interaction databases

BioGridi127003. 1 interactor.
IntActiQ67FW5. 1 interactor.
MINTiMINT-1413862.
STRINGi9606.ENSP00000319979.

Structurei

3D structure databases

ProteinModelPortaliQ67FW5.
SMRiQ67FW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Phylogenomic databases

eggNOGiKOG2977. Eukaryota.
COG0463. LUCA.
GeneTreeiENSGT00390000006933.
HOGENOMiHOG000022151.
HOVERGENiHBG097594.
InParanoidiQ67FW5.
OMAiKGFYCHE.
OrthoDBiEOG091G0AX4.
PhylomeDBiQ67FW5.
TreeFamiTF315120.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q67FW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAGVGGAS EESQAMQAHV SIILPVHNAE PWLDECLRSV LQQDFEGTME
60 70 80 90 100
LSVFNDASKD KSGAIIEKWR VKLEDSGVHV IIGGHDSPSP RGVGYAKNQA
110 120 130 140 150
VAQSSGSYLC FLDSDDVMMP QRVRLQHEAA VQHPSSIIGC RVRRDPPNST
160 170 180 190 200
ERYTRWINQL TPEQLLTQVF TSNGPTVIMP TWFCSRAWFS HVGPFNEGGQ
210 220 230 240 250
GVPEDLLFFY EHLRKGGGVI RVDQSLLLYR HHPQAATHCV LETTIWTHRV
260 270 280 290 300
RFLEEQALPR WAAFTIWNAG KQGRRLYRSL TAGSQRKVVA FCDVDENKIR
310 320 330 340 350
KGFYCHEDSQ ERPKPRIPIL HFRAARPPFV ICVKLDLTGG AFEDNLRSLH
360
LQEGQDFLHF S
Length:361
Mass (Da):40,713
Last modified:May 18, 2010 - v2
Checksum:i582F65C4C61E4BB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13S → R in AAQ74775 (PubMed:15560372).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032603341A → T.Corresponds to variant rs7225887dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY304503 mRNA. Translation: AAQ74775.1.
AY634364 mRNA. Translation: AAT47555.1.
BC019623 mRNA. Translation: AAH19623.1.
CCDSiCCDS32778.1.
RefSeqiNP_001009905.1. NM_001009905.2.
XP_006722335.1. XM_006722272.3.
UniGeneiHs.607824.
Hs.733194.

Genome annotation databases

EnsembliENST00000320865; ENSP00000319979; ENSG00000175711.
ENST00000621596; ENSP00000480784; ENSG00000277033.
GeneIDi146712.
KEGGihsa:146712.
UCSCiuc002kgg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY304503 mRNA. Translation: AAQ74775.1.
AY634364 mRNA. Translation: AAT47555.1.
BC019623 mRNA. Translation: AAH19623.1.
CCDSiCCDS32778.1.
RefSeqiNP_001009905.1. NM_001009905.2.
XP_006722335.1. XM_006722272.3.
UniGeneiHs.607824.
Hs.733194.

3D structure databases

ProteinModelPortaliQ67FW5.
SMRiQ67FW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127003. 1 interactor.
IntActiQ67FW5. 1 interactor.
MINTiMINT-1413862.
STRINGi9606.ENSP00000319979.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

PTM databases

iPTMnetiQ67FW5.
PhosphoSitePlusiQ67FW5.

Polymorphism and mutation databases

BioMutaiB3GNTL1.
DMDMi296434405.

Proteomic databases

EPDiQ67FW5.
MaxQBiQ67FW5.
PaxDbiQ67FW5.
PeptideAtlasiQ67FW5.
PRIDEiQ67FW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320865; ENSP00000319979; ENSG00000175711.
ENST00000621596; ENSP00000480784; ENSG00000277033.
GeneIDi146712.
KEGGihsa:146712.
UCSCiuc002kgg.1. human.

Organism-specific databases

CTDi146712.
DisGeNETi146712.
GeneCardsiB3GNTL1.
HGNCiHGNC:21727. B3GNTL1.
HPAiHPA023585.
HPA024547.
MIMi615337. gene.
neXtProtiNX_Q67FW5.
OpenTargetsiENSG00000175711.
ENSG00000277033.
PharmGKBiPA134910219.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2977. Eukaryota.
COG0463. LUCA.
GeneTreeiENSGT00390000006933.
HOGENOMiHOG000022151.
HOVERGENiHBG097594.
InParanoidiQ67FW5.
OMAiKGFYCHE.
OrthoDBiEOG091G0AX4.
PhylomeDBiQ67FW5.
TreeFamiTF315120.

Enzyme and pathway databases

ReactomeiR-HSA-913709. O-linked glycosylation of mucins.

Miscellaneous databases

ChiTaRSiB3GNTL1. human.
GenomeRNAii146712.
PROiQ67FW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175711.
CleanExiHS_B3GNT8.
HS_B3GNTL1.
ExpressionAtlasiQ67FW5. baseline and differential.
GenevisibleiQ67FW5. HS.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB3GNL_HUMAN
AccessioniPrimary (citable) accession number: Q67FW5
Secondary accession number(s): Q6GV30, Q8WUT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.