Q67FW5 (B3GNL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1
Short name=BGnT-like protein 1
Short name=Beta1,3-N-acetylglucosaminyltransferase-like protein 1
Short name=Beta3Gn-T-like protein 1
Short name=Beta3GnTL1
EC=2.4.1.-

Alternative name(s):
Beta-1,3-N-acetylglucosaminyltransferase 8
Short name=BGnT-8
Short name=Beta-1,3-Gn-T8
Short name=Beta3Gn-T8

Gene names

Name:	B3GNTL1
Synonyms:	B3GNT8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative glycosyltransferase Potential.
Tissue specificity	Widely expressed. Highly expressed in adult pancreas. Expressed at moderate level in kidney, spleen, thymus, prostate, testis and ovary. Weakly expressed in small intestine, colon, peripheral blood leukocyte and liver. Ref.1
Sequence similarities	Belongs to the glycosyltransferase 2 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1		PRO_0000289220
Natural variations
	Natural variant	341	1	A → T. Corresponds to variant rs7225887 [ dbSNP | Ensembl ].		VAR_032603
Experimental info
	Sequence conflict	13	1	S → R in AAQ74775. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q67FW5 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 582F65C4C61E4BB6	FASTA	361	40,713
	10 20 30 40 50 60 MSGAGVGGAS EESQAMQAHV SIILPVHNAE PWLDECLRSV LQQDFEGTME LSVFNDASKD 70 80 90 100 110 120 KSGAIIEKWR VKLEDSGVHV IIGGHDSPSP RGVGYAKNQA VAQSSGSYLC FLDSDDVMMP 130 140 150 160 170 180 QRVRLQHEAA VQHPSSIIGC RVRRDPPNST ERYTRWINQL TPEQLLTQVF TSNGPTVIMP 190 200 210 220 230 240 TWFCSRAWFS HVGPFNEGGQ GVPEDLLFFY EHLRKGGGVI RVDQSLLLYR HHPQAATHCV 250 260 270 280 290 300 LETTIWTHRV RFLEEQALPR WAAFTIWNAG KQGRRLYRSL TAGSQRKVVA FCDVDENKIR 310 320 330 340 350 360 KGFYCHEDSQ ERPKPRIPIL HFRAARPPFV ICVKLDLTGG AFEDNLRSLH LQEGQDFLHF S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase." Zheng H., Li Y., Ji C., Li J., Zhang J., Yin G., Xu J., Ye X., Wu M., Zou X., Gu S., Xie Y., Mao Y. Mol. Biol. Rep. 31:171-175(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	Huang C.Q., Wu S.L., Zhou J.L. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-361. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY304503 mRNA. Translation: AAQ74775.1. AY634364 mRNA. Translation: AAT47555.1. BC019623 mRNA. Translation: AAH19623.1.
IPI	IPI00174847.
RefSeq	NP_001009905.1. NM_001009905.1.
UniGene	Hs.607824.
3D structure databases
ProteinModelPortal	Q67FW5.
SMR	Q67FW5. Positions 20-116.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q67FW5. 1 interaction.
MINT	MINT-1413862.
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
PTM databases
PhosphoSite	Q67FW5.
Polymorphism databases
DMDM	296434405.
Proteomic databases
PaxDb	Q67FW5.
PRIDE	Q67FW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320865; ENSP00000319979; ENSG00000175711.
GeneID	146712.
KEGG	hsa:146712.
UCSC	uc002kgf.1. human.
Organism-specific databases
CTD	146712.
GeneCards	GC17M080901.
HGNC	HGNC:21727. B3GNTL1.
HPA	HPA023585. HPA024547.
neXtProt	NX_Q67FW5.
PharmGKB	PA134910219.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0463.
HOGENOM	HOG000022151.
HOVERGEN	HBG097594.
InParanoid	Q67FW5.
OMA	FCSREWF.
OrthoDB	EOG4XD3RK.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	Q67FW5.
Bgee	Q67FW5.
CleanEx	HS_B3GNT8. HS_B3GNTL1.
Genevestigator	Q67FW5.
Family and domain databases
InterPro	IPR001173. Glyco_trans_2. [Graphical view]
Pfam	PF00535. Glycos_transf_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	146712.
NextBio	85424.

Entry information

Entry name

B3GNL_HUMAN

Accession

Primary (citable) accession number: Q67FW5
Secondary accession number(s): Q6GV30, Q8WUT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.