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Protein

Taste receptor type 2 member 39

Gene

Tas2r39

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Putative taste receptor which may play a role in the perception of bitterness.Curated

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Enzyme and pathway databases

ReactomeiR-RNO-418594. G alpha (i) signalling events.
R-RNO-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 39
Short name:
T2R39
Alternative name(s):
Taste receptor type 2 member 32
Short name:
T2R32
Gene namesi
Name:Tas2r39By similarity
Synonyms:Tas2r32
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1595436. Tas2r39.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini38 – 56CytoplasmicSequence analysisAdd BLAST19
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 97ExtracellularSequence analysisAdd BLAST20
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 187ExtracellularSequence analysisAdd BLAST29
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 247CytoplasmicSequence analysisAdd BLAST39
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini269 – 273ExtracellularSequence analysis5
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 319CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002476581 – 319Taste receptor type 2 member 39Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ67ER9.
PRIDEiQ67ER9.

PTM databases

PhosphoSitePlusiQ67ER9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028135.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035471.

Structurei

3D structure databases

ProteinModelPortaliQ67ER9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor T2R family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEI. Eukaryota.
ENOG410YMY3. LUCA.
GeneTreeiENSGT00760000119096.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ67ER9.
KOiK08474.
OMAiWRISELM.
OrthoDBiEOG091G0FKI.
PhylomeDBiQ67ER9.
TreeFamiTF335891.

Family and domain databases

InterProiView protein in InterPro
IPR017452. GPCR_Rhodpsn_7TM.
IPR007960. T2R.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q67ER9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPSNYWKQ DLLPLSILIL TLVATECTIG IIASGIITVV NAVSWVQKRA
60 70 80 90 100
VSITTRILLL LSVSRIGLQS IILIEMTSSI FNFSSYNSVL YRVSRVSFVF
110 120 130 140 150
LNYCSLWFAA LLSFFHFVKI ANFSYPLFFK LKWRISELMP WLLWLSVFIS
160 170 180 190 200
FSSSMFFCNH KYTVYNNISL SSNICNFTME LYVAEANVVN VAFLFSFGIL
210 220 230 240 250
PPLTMFIATA TLLIFSLRRH TLHMRNGDAD SRNPRVEAHK QAIKETSCFL
260 270 280 290 300
FLYILYAAVL FLSTSNIADA SLFWSSVLRI SLPVYPAGHS VLLIQSNPGL
310
KRTWKQLLSQ IHLHLQSRY
Length:319
Mass (Da):36,420
Last modified:October 11, 2004 - v1
Checksum:iF6A2952B95EBA269
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY362751 Genomic DNA. Translation: AAR13360.1.
RefSeqiNP_001074374.1. NM_001080905.1.
UniGeneiRn.202938.

Genome annotation databases

EnsembliENSRNOT00000037220; ENSRNOP00000035471; ENSRNOG00000028135.
GeneIDi680188.
KEGGirno:680188.
UCSCiRGD:1595436. rat.

Similar proteinsi

Entry informationi

Entry nameiT2R39_RAT
AccessioniPrimary (citable) accession number: Q67ER9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 11, 2004
Last modified: August 30, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families