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Protein

C-type lectin domain family 4 member E

Gene

Clec4e

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • positive regulation of cytokine secretion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member E
Alternative name(s):
C-type lectin superfamily member 9
Macrophage-inducible C-type lectin
Gene namesi
Name:Clec4e
Synonyms:Clecsf9, Mincle
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359298. Clec4e.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4623Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini47 – 215169ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215C-type lectin domain family 4 member EPRO_0000046621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi81 ↔ 92PROSITE-ProRule annotation
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Disulfide bondi109 ↔ 206PROSITE-ProRule annotation
Disulfide bondi180 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ67EQ1.

PTM databases

PhosphoSiteiQ67EQ1.

Expressioni

Tissue specificityi

Expressed in dendritic cells, macrophages, neutrophils and in B-cells.1 Publication

Interactioni

Subunit structurei

Monomer. Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013562.

Structurei

3D structure databases

ProteinModelPortaliQ67EQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 207120C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ67EQ1.
KOiK10059.
PhylomeDBiQ67EQ1.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67EQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTKSPASH HTERECFKNS QVLSWTMAGA SILFLSVCFI TRCVVTYHSF
60 70 80 90 100
QIYGQKKLQP HKTIKELSCY LEASGSVKNC CPLNWKHFQS SCYFFSTTTL
110 120 130 140 150
SWLSSLKNCS DMGAHLVVIN TWEEQEFLFR TKPRKKEFYI GLTDQVVEGQ
160 170 180 190 200
WRWVDDTPFT ESLSFWDAGE PNNIVFVEDC ATMRDSSNPR KNWNDVSCFF
210
SMPWICEMPE ISPLD
Length:215
Mass (Da):24,911
Last modified:October 11, 2004 - v1
Checksum:i417871E615D2A7F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363175 mRNA. Translation: AAR18685.1.
AY581049 mRNA. Translation: AAT92025.1.
RefSeqiNP_001005897.1. NM_001005897.1.
UniGeneiRn.127512.

Genome annotation databases

GeneIDi450223.
KEGGirno:450223.
UCSCiRGD:1359298. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363175 mRNA. Translation: AAR18685.1.
AY581049 mRNA. Translation: AAT92025.1.
RefSeqiNP_001005897.1. NM_001005897.1.
UniGeneiRn.127512.

3D structure databases

ProteinModelPortaliQ67EQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013562.

PTM databases

PhosphoSiteiQ67EQ1.

Proteomic databases

PaxDbiQ67EQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi450223.
KEGGirno:450223.
UCSCiRGD:1359298. rat.

Organism-specific databases

CTDi26253.
RGDi1359298. Clec4e.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ67EQ1.
KOiK10059.
PhylomeDBiQ67EQ1.

Miscellaneous databases

NextBioi697151.
PROiQ67EQ1.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex."
    Flornes L.M., Bryceson Y.T., Spurkland A., Lorentzen J.C., Dissen E., Fossum S.
    Immunogenetics 56:506-517(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: PVG.
  2. "Genes encoding lectin-like receptors are associated with arthritis in the rat."
    Lorentzen J.C., Flornes L.M., Dissen E., Fossum S.R.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Lewis.

Entry informationi

Entry nameiCLC4E_RAT
AccessioniPrimary (citable) accession number: Q67EQ1
Secondary accession number(s): Q56TZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 11, 2004
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.