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Protein

C-type lectin domain family 4 member E

Gene

Clec4e

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • signaling receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • positive regulation of cytokine secretion Source: UniProtKB

Keywordsi

Biological processImmunity
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member E
Alternative name(s):
C-type lectin superfamily member 9
Macrophage-inducible C-type lectin
Gene namesi
Name:Clec4e
Synonyms:Clecsf9, Mincle
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1359298 Clec4e

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 46Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini47 – 215ExtracellularSequence analysisAdd BLAST169

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466211 – 215C-type lectin domain family 4 member EAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 92PROSITE-ProRule annotation
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 206PROSITE-ProRule annotation
Disulfide bondi180 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ67EQ1
PRIDEiQ67EQ1

PTM databases

iPTMnetiQ67EQ1
PhosphoSitePlusiQ67EQ1

Expressioni

Tissue specificityi

Expressed in dendritic cells, macrophages, neutrophils and in B-cells.1 Publication

Interactioni

Subunit structurei

Monomer. Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013562

Structurei

3D structure databases

ProteinModelPortaliQ67EQ1
SMRiQ67EQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 207C-type lectinPROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000059556
HOVERGENiHBG050992
InParanoidiQ67EQ1
KOiK10059
PhylomeDBiQ67EQ1

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q67EQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTKSPASH HTERECFKNS QVLSWTMAGA SILFLSVCFI TRCVVTYHSF
60 70 80 90 100
QIYGQKKLQP HKTIKELSCY LEASGSVKNC CPLNWKHFQS SCYFFSTTTL
110 120 130 140 150
SWLSSLKNCS DMGAHLVVIN TWEEQEFLFR TKPRKKEFYI GLTDQVVEGQ
160 170 180 190 200
WRWVDDTPFT ESLSFWDAGE PNNIVFVEDC ATMRDSSNPR KNWNDVSCFF
210
SMPWICEMPE ISPLD
Length:215
Mass (Da):24,911
Last modified:October 11, 2004 - v1
Checksum:i417871E615D2A7F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363175 mRNA Translation: AAR18685.1
AY581049 mRNA Translation: AAT92025.1
RefSeqiNP_001005897.1, NM_001005897.1
UniGeneiRn.127512

Genome annotation databases

GeneIDi450223
KEGGirno:450223
UCSCiRGD:1359298 rat

Entry informationi

Entry nameiCLC4E_RAT
AccessioniPrimary (citable) accession number: Q67EQ1
Secondary accession number(s): Q56TZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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