Reviewed, UniProtKB/Swiss-Prot Q67E00 (DUSTY_XENTR)

Names and origin

Protein names

Recommended name:
    Dual serine/threonine and tyrosine protein kinase
    EC=2.7.12.1
Alternative name(s):
    Dusty protein kinase
      Short name=Dusty PK
    Receptor-interacting serine/threonine-protein kinase 5

Gene names

Name:	dstyk
Synonyms:	ripk5

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	918 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May induce both caspase-dependent apoptosis and caspase-independent cell death By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 918	918	Dual serine/threonine and tyrosine protein kinase		PRO_0000233126
Regions
	Domain	643 – 897	255	Protein kinase
	Nucleotide binding	649 – 657	9	ATP By similarity
Sites
	Active site	768	1	Proton acceptor By similarity
	Binding site	672	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q67E00-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 30F28DAA8D9889F9	FASTA	918	104,337
	10 20 30 40 50 60 MQKDGTRSSR RMEEGDRRNG STGSSGSVSR ELGRGFSYYN KYLARLQQNL RDTKRFFRDI 70 80 90 100 110 120 KHTYSGAPGG PDTDIKGAEG DLGQLHSITF PRQEEEYLKL TVRCRPCIFI LGQSCSSRGR 130 140 150 160 170 180 VANSLLGDQL LPILTHCGSE CCKRRRIRFR YGKQTLVSLA LPEQYELVHE LVAHQGKWDT 190 200 210 220 230 240 IPEEDLDVPE DEEDPAHRLA ELEVTLPHQL LQDVDIVVSP CRSSQAVSMT LEDYVDHVQS 250 260 270 280 290 300 IVVYAVCEER LSQQDEEELT EIKEKYKLPV FFIRTSSTRD RLIGGSEGVR SALYEQLMEL 310 320 330 340 350 360 GFLKRGLCNC GAAGSGSTAP SMLVEQFEKL RQVSTFSRQV LQMHLVDAAI VLNMVHSRCL 370 380 390 400 410 420 DLFINKAFDM HRDLQITPKR LEYTRQKENE LYESLMRISD RKQEELKDMI VETLNSMREQ 430 440 450 460 470 480 LLEDAANMQF KDIAIPQNGE PVSVQEVKCC IFQIKELIIS RLNQAVVNKL ISSVDYLRES 490 500 510 520 530 540 FVGTLERCLR SLEKSQQESS SHVTSNHLKQ ILNAAYHVEV TFNSGSTVTR MVWEQIVQII 550 560 570 580 590 600 QRITWVSPPT ITPEWKRRVA QDAIESLSAS KLAKSICSQF CKRLKSSHEA FAASLKQLEV 610 620 630 640 650 660 GHSGRLEKTN DLWLRVRKDH APRLARLSLE SRSLQDVLLH GKPRIGRELG RGQYGVVYLC 670 680 690 700 710 720 DSWGGHFPCA LKSVVPPDEK HWNDLALEFH YMRSLPKHER LVDLHGSVID YSYGGGSSIA 730 740 750 760 770 780 VLLITERLHR DLYVGLKTGL SLETRLQIAL DVVEGIRFLH NQGLVHRDIK LKNVLLDKKH 790 800 810 820 830 840 RAKITDLGFC KPEAMMSGSI VGTPIHMAPE LFSGKYDNSV DVYAFGILFW YICSGSVKLP 850 860 870 880 890 900 EAFEKCASKD HLWNNVRKGA RPERLAIFDE ECWKLMEACW NGDPSQRPLM GIVQPMLQGI 910 MDRLCRAQET GKALEDST

References

[1]

"Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain." Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H. Biochim. Biophys. Acta 1759:562-572(2006) [PubMed: 17123648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY364233 mRNA. Translation: AAR13048.1. AY429679 mRNA. Translation: AAS55395.1.
RefSeq	NP_001007477.1.
UniGene	Str.26767
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSXETT00000001971; ENSXETP00000001971; ENSXETG00000000902; Xenopus tropicalis. [Genome view]
GeneID	493205.
KEGG	xtr:493205.
Organism-specific databases
CTD	493205.
Xenbase	XB-FEAT-971396. dstyk.
Phylogenomic databases
HOVERGEN	Q67E00.
Enzyme and pathway databases
BRENDA	2.7.11.1. 279072.
Gene expression databases
Bgee	Q67E00.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUSTY_XENTR

Accession

Primary (citable) accession number: Q67E00

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	October 11, 2004
Last modified:	September 1, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project