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Protein

Mitogen-activated protein kinase 7

Gene

MPK7

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATPPROSITE-ProRule annotation
Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 7 (EC:2.7.11.24)
Short name:
MAP kinase 7
Alternative name(s):
MAP kinase 6
OsMAPK6
Gene namesi
Name:MPK7
Synonyms:MAPK6
Ordered Locus Names:Os05g0566400, LOC_Os05g49140
ORF Names:OJ1781_H11.5, OJ1781_H11.6
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 5

Organism-specific databases

GrameneiQ67C40.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Mitogen-activated protein kinase 7PRO_0000239750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751PhosphothreonineBy similarity
Modified residuei177 – 1771PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ67C40.

Expressioni

Inductioni

By jasmonic acid (JA) and infection with rice blast fungus (M.grisea).1 Publication

Gene expression databases

ExpressionAtlasiQ67C40. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ67C40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 304292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi175 – 1773TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ67C40.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67C40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFFSEYGDS SRYKIQEIVG KGSYGVVCSA IDQHTGDKVA IKKIHNIFEH
60 70 80 90 100
LSDAARILRE IKLLRLLRHP DIVEIKHIML PPSRRDFKDI YVVFELMDTD
110 120 130 140 150
LHQVIKANDD LTKEHHQFFL YQMLRALKYI HTANVYHRDL KPKNILANAN
160 170 180 190 200
CKLKICDFGL ARVAFNDTPT TVFWTDYVAT RWYRAPELCG SFFSKYSPAI
210 220 230 240 250
DTWSIGCIFA EILTGKPLFP GKNVVHQLDL MTDLLGTPSM DAISRIRNDK
260 270 280 290 300
ARRYLSSMRR KQPVPFSEKF PNVDPLALKL LQRLLAFDPK DRPTAEEALA
310 320 330 340 350
DPYFKGLAKV EREPSCQPIS KMEFEFERRK VTKDDIKELI FREILEYHPQ
360 370 380 390 400
LLKDYMNGSE NTSFLYPSAV DNFRRQFAIL EENGGKSGAL DRKHVSLPRA
410 420 430 440 450
TTVHSTSIPP NEGLDATSQV TQRIPTARPG RTVGPVLPFE NPGAADPHSA
460 470 480 490 500
RRVVRNPMVP PAAANKSGYS YNLKSDYSDR QHQEELEKDR VQYRPAQHLM
510 520 530 540 550
DAKVAPDTAP DIRSSQYYFT RSAPRTDLTD RAALQGSMLY GIAPFNGIAA
560
VAGGYSKVGA VQYGVSRMY
Length:569
Mass (Da):64,669
Last modified:October 11, 2004 - v1
Checksum:iF2A244BB1D2D8D91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366480 mRNA. Translation: AAR11478.1.
AC120986 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366480 mRNA. Translation: AAR11478.1.
AC120986 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ67C40.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ67C40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GrameneiQ67C40.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ67C40.

Gene expression databases

ExpressionAtlasiQ67C40. baseline.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel MAP kinase-OsMAPK6 involved in the developmental regulation for rice plants."
    Wang Y.D., Chen X., Ye Z., Wei M.L.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, NOMENCLATURE.

Entry informationi

Entry nameiMPK7_ORYSJ
AccessioniPrimary (citable) accession number: Q67C40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.