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Protein

Solute carrier family 13 member 5

Gene

Slc13a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol (By similarity).By similarity

GO - Molecular functioni

  • citrate transmembrane transporter activity Source: MGI
  • sodium:dicarboxylate symporter activity Source: GO_Central
  • succinate transmembrane transporter activity Source: MGI
  • tricarboxylic acid transmembrane transporter activity Source: MGI

GO - Biological processi

  • citrate transport Source: MGI
  • succinate transport Source: MGI
  • tricarboxylic acid transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 5
Alternative name(s):
Na(+)/citrate cotransporter
Short name:
NaCT
Sodium-coupled citrate transporter
Sodium-dependent citrate transporter
Gene namesi
Name:Slc13a5
Synonyms:Nact
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3037150. Slc13a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002601021 – 572Solute carrier family 13 member 5Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi382N-linked (GlcNAc...)Sequence analysis1
Glycosylationi566N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ67BT3.
PRIDEiQ67BT3.

PTM databases

iPTMnetiQ67BT3.
PhosphoSitePlusiQ67BT3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020805.
ExpressionAtlasiQ67BT3. baseline and differential.
GenevisibleiQ67BT3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021161.

Structurei

3D structure databases

ProteinModelPortaliQ67BT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ67BT3.
KOiK14445.
OMAiCEMALAV.
OrthoDBiEOG091G092X.
PhylomeDBiQ67BT3.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67BT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAKTCVTK FKSFAILLFT PILMLPLVIL IPDKFARCAY VIVIMAVYWC
60 70 80 90 100
TDVIPVAVTS LLPVLLFPLL KVLDSKQVCI QYMKDTNMLF LGSLIVAVAV
110 120 130 140 150
ERWKLHKRVA LRMLLFVGTK PSRLMLGFMF VTAFLSMWIS NTAATAMMIP
160 170 180 190 200
IVEAMLQQMI AANTAVEASL GTLELLDKNK TSELPGSQVV FEDPNVQEQE
210 220 230 240 250
DEETKNMYKA MHLCVCYSAS IGGTATLTGT GPNVVLLGQM QELFPDSKDV
260 270 280 290 300
LNYASWFGFA FPNMVMMLVL AWLWLQCLYM RHNLKKTCIC CGEKKRDTEK
310 320 330 340 350
IAYKVLNEEY QKLGSLSYPE CNVLFCFTLL VILWFSRDPG FMPGWLSFAW
360 370 380 390 400
VEGNTVHITD ATVAIFVAIL LFIIPSQKPK FNFSSQTEEE RKTPFYPPAL
410 420 430 440 450
LDWKVAQEKV PWDIVLLLGG GFAMAKGCET SGLSKWMAAQ MEPLRLVKPA
460 470 480 490 500
VITLILSCLV AMTTECTSNV ATTTLFLPIF ASMARSIGIH PLYVMIPCTM
510 520 530 540 550
SASLAFMLPV ATPPNAIVFA YGHLRVVDMM KTGLIMNFVG ILSVFLSVNT
560 570
WGRAMFNLDN FPDWANSTSV NT
Length:572
Mass (Da):63,823
Last modified:October 11, 2004 - v1
Checksum:i329C8C48C6624739
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY368893 mRNA. Translation: AAR14317.1.
AK048662 mRNA. Translation: BAE20664.1.
AL929071 Genomic DNA. Translation: CAI36028.1.
CCDSiCCDS24983.1.
RefSeqiNP_001004148.1. NM_001004148.4.
UniGeneiMm.340778.

Genome annotation databases

EnsembliENSMUST00000021161; ENSMUSP00000021161; ENSMUSG00000020805.
GeneIDi237831.
KEGGimmu:237831.
UCSCiuc007jym.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY368893 mRNA. Translation: AAR14317.1.
AK048662 mRNA. Translation: BAE20664.1.
AL929071 Genomic DNA. Translation: CAI36028.1.
CCDSiCCDS24983.1.
RefSeqiNP_001004148.1. NM_001004148.4.
UniGeneiMm.340778.

3D structure databases

ProteinModelPortaliQ67BT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021161.

PTM databases

iPTMnetiQ67BT3.
PhosphoSitePlusiQ67BT3.

Proteomic databases

PaxDbiQ67BT3.
PRIDEiQ67BT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021161; ENSMUSP00000021161; ENSMUSG00000020805.
GeneIDi237831.
KEGGimmu:237831.
UCSCiuc007jym.2. mouse.

Organism-specific databases

CTDi284111.
MGIiMGI:3037150. Slc13a5.

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ67BT3.
KOiK14445.
OMAiCEMALAV.
OrthoDBiEOG091G092X.
PhylomeDBiQ67BT3.
TreeFamiTF312913.

Enzyme and pathway databases

ReactomeiR-MMU-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

PROiQ67BT3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020805.
ExpressionAtlasiQ67BT3. baseline and differential.
GenevisibleiQ67BT3. MM.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS13A5_MOUSE
AccessioniPrimary (citable) accession number: Q67BT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.