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Protein

Solute carrier family 13 member 5

Gene

Slc13a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol (By similarity).By similarity

GO - Molecular functioni

  • citrate transmembrane transporter activity Source: MGI
  • sodium:dicarboxylate symporter activity Source: GO_Central
  • succinate transmembrane transporter activity Source: MGI
  • tricarboxylic acid transmembrane transporter activity Source: MGI

GO - Biological processi

  • citrate transport Source: MGI
  • succinate transport Source: MGI
  • tricarboxylic acid transport Source: MGI

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 5
Alternative name(s):
Na(+)/citrate cotransporter
Short name:
NaCT
Sodium-coupled citrate transporter
Sodium-dependent citrate transporter
Gene namesi
Name:Slc13a5
Synonyms:Nact
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3037150. Slc13a5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3769294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002601021 – 572Solute carrier family 13 member 5Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ67BT3.
PRIDEiQ67BT3.

PTM databases

iPTMnetiQ67BT3.
PhosphoSitePlusiQ67BT3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020805.
ExpressionAtlasiQ67BT3. baseline and differential.
GenevisibleiQ67BT3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021161.

Structurei

3D structure databases

ProteinModelPortaliQ67BT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ67BT3.
KOiK14445.
OMAiIWWMTEA.
OrthoDBiEOG091G092X.
PhylomeDBiQ67BT3.
TreeFamiTF312913.

Family and domain databases

InterProiView protein in InterPro
IPR031312. Na/sul_symport_CS.
IPR001898. SLC13A/DASS.
PfamiView protein in Pfam
PF00939. Na_sulph_symp. 1 hit.
PROSITEiView protein in PROSITE
PS01271. NA_SULFATE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q67BT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAKTCVTK FKSFAILLFT PILMLPLVIL IPDKFARCAY VIVIMAVYWC
60 70 80 90 100
TDVIPVAVTS LLPVLLFPLL KVLDSKQVCI QYMKDTNMLF LGSLIVAVAV
110 120 130 140 150
ERWKLHKRVA LRMLLFVGTK PSRLMLGFMF VTAFLSMWIS NTAATAMMIP
160 170 180 190 200
IVEAMLQQMI AANTAVEASL GTLELLDKNK TSELPGSQVV FEDPNVQEQE
210 220 230 240 250
DEETKNMYKA MHLCVCYSAS IGGTATLTGT GPNVVLLGQM QELFPDSKDV
260 270 280 290 300
LNYASWFGFA FPNMVMMLVL AWLWLQCLYM RHNLKKTCIC CGEKKRDTEK
310 320 330 340 350
IAYKVLNEEY QKLGSLSYPE CNVLFCFTLL VILWFSRDPG FMPGWLSFAW
360 370 380 390 400
VEGNTVHITD ATVAIFVAIL LFIIPSQKPK FNFSSQTEEE RKTPFYPPAL
410 420 430 440 450
LDWKVAQEKV PWDIVLLLGG GFAMAKGCET SGLSKWMAAQ MEPLRLVKPA
460 470 480 490 500
VITLILSCLV AMTTECTSNV ATTTLFLPIF ASMARSIGIH PLYVMIPCTM
510 520 530 540 550
SASLAFMLPV ATPPNAIVFA YGHLRVVDMM KTGLIMNFVG ILSVFLSVNT
560 570
WGRAMFNLDN FPDWANSTSV NT
Length:572
Mass (Da):63,823
Last modified:October 11, 2004 - v1
Checksum:i329C8C48C6624739
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY368893 mRNA. Translation: AAR14317.1.
AK048662 mRNA. Translation: BAE20664.1.
AL929071 Genomic DNA. Translation: CAI36028.1.
CCDSiCCDS24983.1.
RefSeqiNP_001004148.1. NM_001004148.4.
UniGeneiMm.340778.

Genome annotation databases

EnsembliENSMUST00000021161; ENSMUSP00000021161; ENSMUSG00000020805.
GeneIDi237831.
KEGGimmu:237831.
UCSCiuc007jym.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiS13A5_MOUSE
AccessioniPrimary (citable) accession number: Q67BT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 11, 2004
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families