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Protein

Solute carrier family 13 member 5

Gene

Slc13a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol (By similarity).By similarity

GO - Molecular functioni

  1. citrate transmembrane transporter activity Source: MGI
  2. sodium:dicarboxylate symporter activity Source: Ensembl
  3. succinate transmembrane transporter activity Source: MGI
  4. tricarboxylic acid transmembrane transporter activity Source: MGI

GO - Biological processi

  1. citrate transport Source: MGI
  2. succinate transmembrane transport Source: GOC
  3. succinate transport Source: MGI
  4. tricarboxylic acid transmembrane transport Source: GOC
  5. tricarboxylic acid transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_348160. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 5
Alternative name(s):
Na(+)/citrate cotransporter
Short name:
NaCT
Sodium-coupled citrate transporter
Sodium-dependent citrate transporter
Gene namesi
Name:Slc13a5
Synonyms:Nact
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3037150. Slc13a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence AnalysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence AnalysisAdd
BLAST
Transmembranei443 – 46321HelicalSequence AnalysisAdd
BLAST
Transmembranei491 – 51121HelicalSequence AnalysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Solute carrier family 13 member 5PRO_0000260102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ67BT3.
PRIDEiQ67BT3.

PTM databases

PhosphoSiteiQ67BT3.

Expressioni

Gene expression databases

BgeeiQ67BT3.
ExpressionAtlasiQ67BT3. baseline and differential.
GenevestigatoriQ67BT3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021161.

Structurei

3D structure databases

ProteinModelPortaliQ67BT3.
SMRiQ67BT3. Positions 41-271, 400-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ67BT3.
KOiK14445.
OMAiXLMLGFM.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ67BT3.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67BT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSAKTCVTK FKSFAILLFT PILMLPLVIL IPDKFARCAY VIVIMAVYWC
60 70 80 90 100
TDVIPVAVTS LLPVLLFPLL KVLDSKQVCI QYMKDTNMLF LGSLIVAVAV
110 120 130 140 150
ERWKLHKRVA LRMLLFVGTK PSRLMLGFMF VTAFLSMWIS NTAATAMMIP
160 170 180 190 200
IVEAMLQQMI AANTAVEASL GTLELLDKNK TSELPGSQVV FEDPNVQEQE
210 220 230 240 250
DEETKNMYKA MHLCVCYSAS IGGTATLTGT GPNVVLLGQM QELFPDSKDV
260 270 280 290 300
LNYASWFGFA FPNMVMMLVL AWLWLQCLYM RHNLKKTCIC CGEKKRDTEK
310 320 330 340 350
IAYKVLNEEY QKLGSLSYPE CNVLFCFTLL VILWFSRDPG FMPGWLSFAW
360 370 380 390 400
VEGNTVHITD ATVAIFVAIL LFIIPSQKPK FNFSSQTEEE RKTPFYPPAL
410 420 430 440 450
LDWKVAQEKV PWDIVLLLGG GFAMAKGCET SGLSKWMAAQ MEPLRLVKPA
460 470 480 490 500
VITLILSCLV AMTTECTSNV ATTTLFLPIF ASMARSIGIH PLYVMIPCTM
510 520 530 540 550
SASLAFMLPV ATPPNAIVFA YGHLRVVDMM KTGLIMNFVG ILSVFLSVNT
560 570
WGRAMFNLDN FPDWANSTSV NT
Length:572
Mass (Da):63,823
Last modified:October 10, 2004 - v1
Checksum:i329C8C48C6624739
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY368893 mRNA. Translation: AAR14317.1.
AK048662 mRNA. Translation: BAE20664.1.
AL929071 Genomic DNA. Translation: CAI36028.1.
CCDSiCCDS24983.1.
RefSeqiNP_001004148.1. NM_001004148.4.
XP_006533284.2. XM_006533221.2.
UniGeneiMm.340778.

Genome annotation databases

EnsembliENSMUST00000021161; ENSMUSP00000021161; ENSMUSG00000020805.
GeneIDi237831.
KEGGimmu:237831.
UCSCiuc007jym.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY368893 mRNA. Translation: AAR14317.1.
AK048662 mRNA. Translation: BAE20664.1.
AL929071 Genomic DNA. Translation: CAI36028.1.
CCDSiCCDS24983.1.
RefSeqiNP_001004148.1. NM_001004148.4.
XP_006533284.2. XM_006533221.2.
UniGeneiMm.340778.

3D structure databases

ProteinModelPortaliQ67BT3.
SMRiQ67BT3. Positions 41-271, 400-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021161.

PTM databases

PhosphoSiteiQ67BT3.

Proteomic databases

PaxDbiQ67BT3.
PRIDEiQ67BT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021161; ENSMUSP00000021161; ENSMUSG00000020805.
GeneIDi237831.
KEGGimmu:237831.
UCSCiuc007jym.2. mouse.

Organism-specific databases

CTDi284111.
MGIiMGI:3037150. Slc13a5.

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ67BT3.
KOiK14445.
OMAiXLMLGFM.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ67BT3.
TreeFamiTF312913.

Enzyme and pathway databases

ReactomeiREACT_348160. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

NextBioi383514.
PROiQ67BT3.
SOURCEiSearch...

Gene expression databases

BgeeiQ67BT3.
ExpressionAtlasiQ67BT3. baseline and differential.
GenevestigatoriQ67BT3.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for citric acid cycle intermediates."
    Inoue K., Fei Y.-J., Zhuang L., Gopal E., Miyauchi S., Ganapathy V.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiS13A5_MOUSE
AccessioniPrimary (citable) accession number: Q67BT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 27, 2006
Last sequence update: October 10, 2004
Last modified: March 31, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.