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Q67BT3

- S13A5_MOUSE

UniProt

Q67BT3 - S13A5_MOUSE

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Protein
Solute carrier family 13 member 5
Gene
Slc13a5, Nact
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol By similarity.

GO - Molecular functioni

  1. citrate transmembrane transporter activity Source: MGI
  2. sodium:dicarboxylate symporter activity Source: Ensembl
  3. succinate transmembrane transporter activity Source: MGI
  4. tricarboxylic acid transmembrane transporter activity Source: MGI

GO - Biological processi

  1. citrate transport Source: MGI
  2. succinate transport Source: MGI
  3. tricarboxylic acid transmembrane transport Source: GOC
  4. tricarboxylic acid transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 5
Alternative name(s):
Na(+)/citrate cotransporter
Short name:
NaCT
Sodium-coupled citrate transporter
Sodium-dependent citrate transporter
Gene namesi
Name:Slc13a5
Synonyms:Nact
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:3037150. Slc13a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321Helical; Reviewed prediction
Add
BLAST
Transmembranei53 – 7321Helical; Reviewed prediction
Add
BLAST
Transmembranei80 – 10021Helical; Reviewed prediction
Add
BLAST
Transmembranei124 – 14421Helical; Reviewed prediction
Add
BLAST
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Reviewed prediction
Add
BLAST
Transmembranei315 – 33521Helical; Reviewed prediction
Add
BLAST
Transmembranei357 – 37721Helical; Reviewed prediction
Add
BLAST
Transmembranei410 – 43021Helical; Reviewed prediction
Add
BLAST
Transmembranei443 – 46321Helical; Reviewed prediction
Add
BLAST
Transmembranei491 – 51121Helical; Reviewed prediction
Add
BLAST
Transmembranei532 – 55221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Solute carrier family 13 member 5
PRO_0000260102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi382 – 3821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi566 – 5661N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ67BT3.
PRIDEiQ67BT3.

PTM databases

PhosphoSiteiQ67BT3.

Expressioni

Gene expression databases

BgeeiQ67BT3.
GenevestigatoriQ67BT3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021161.

Structurei

3D structure databases

ProteinModelPortaliQ67BT3.
SMRiQ67BT3. Positions 41-271, 400-543.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ67BT3.
KOiK14445.
OMAiIMDSKQV.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ67BT3.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67BT3-1 [UniParc]FASTAAdd to Basket

« Hide

MDSAKTCVTK FKSFAILLFT PILMLPLVIL IPDKFARCAY VIVIMAVYWC    50
TDVIPVAVTS LLPVLLFPLL KVLDSKQVCI QYMKDTNMLF LGSLIVAVAV 100
ERWKLHKRVA LRMLLFVGTK PSRLMLGFMF VTAFLSMWIS NTAATAMMIP 150
IVEAMLQQMI AANTAVEASL GTLELLDKNK TSELPGSQVV FEDPNVQEQE 200
DEETKNMYKA MHLCVCYSAS IGGTATLTGT GPNVVLLGQM QELFPDSKDV 250
LNYASWFGFA FPNMVMMLVL AWLWLQCLYM RHNLKKTCIC CGEKKRDTEK 300
IAYKVLNEEY QKLGSLSYPE CNVLFCFTLL VILWFSRDPG FMPGWLSFAW 350
VEGNTVHITD ATVAIFVAIL LFIIPSQKPK FNFSSQTEEE RKTPFYPPAL 400
LDWKVAQEKV PWDIVLLLGG GFAMAKGCET SGLSKWMAAQ MEPLRLVKPA 450
VITLILSCLV AMTTECTSNV ATTTLFLPIF ASMARSIGIH PLYVMIPCTM 500
SASLAFMLPV ATPPNAIVFA YGHLRVVDMM KTGLIMNFVG ILSVFLSVNT 550
WGRAMFNLDN FPDWANSTSV NT 572
Length:572
Mass (Da):63,823
Last modified:October 11, 2004 - v1
Checksum:i329C8C48C6624739
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY368893 mRNA. Translation: AAR14317.1.
AK048662 mRNA. Translation: BAE20664.1.
AL929071 Genomic DNA. Translation: CAI36028.1.
CCDSiCCDS24983.1.
RefSeqiNP_001004148.1. NM_001004148.4.
UniGeneiMm.340778.

Genome annotation databases

EnsembliENSMUST00000021161; ENSMUSP00000021161; ENSMUSG00000020805.
GeneIDi237831.
KEGGimmu:237831.
UCSCiuc007jym.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY368893 mRNA. Translation: AAR14317.1 .
AK048662 mRNA. Translation: BAE20664.1 .
AL929071 Genomic DNA. Translation: CAI36028.1 .
CCDSi CCDS24983.1.
RefSeqi NP_001004148.1. NM_001004148.4.
UniGenei Mm.340778.

3D structure databases

ProteinModelPortali Q67BT3.
SMRi Q67BT3. Positions 41-271, 400-543.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000021161.

PTM databases

PhosphoSitei Q67BT3.

Proteomic databases

PaxDbi Q67BT3.
PRIDEi Q67BT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021161 ; ENSMUSP00000021161 ; ENSMUSG00000020805 .
GeneIDi 237831.
KEGGi mmu:237831.
UCSCi uc007jym.2. mouse.

Organism-specific databases

CTDi 284111.
MGIi MGI:3037150. Slc13a5.

Phylogenomic databases

eggNOGi COG0471.
GeneTreei ENSGT00550000074480.
HOGENOMi HOG000278432.
HOVERGENi HBG055339.
InParanoidi Q67BT3.
KOi K14445.
OMAi IMDSKQV.
OrthoDBi EOG7G1V5S.
PhylomeDBi Q67BT3.
TreeFami TF312913.

Miscellaneous databases

NextBioi 383514.
PROi Q67BT3.
SOURCEi Search...

Gene expression databases

Bgeei Q67BT3.
Genevestigatori Q67BT3.

Family and domain databases

InterProi IPR001898. Na/sul_symport.
[Graphical view ]
Pfami PF00939. Na_sulph_symp. 1 hit.
[Graphical view ]
PROSITEi PS01271. NA_SULFATE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for citric acid cycle intermediates."
    Inoue K., Fei Y.-J., Zhuang L., Gopal E., Miyauchi S., Ganapathy V.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiS13A5_MOUSE
AccessioniPrimary (citable) accession number: Q67BT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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