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Q67BT3

- S13A5_MOUSE

UniProt

Q67BT3 - S13A5_MOUSE

Protein

Solute carrier family 13 member 5

Gene

Slc13a5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol By similarity.By similarity

    GO - Molecular functioni

    1. citrate transmembrane transporter activity Source: MGI
    2. sodium:dicarboxylate symporter activity Source: Ensembl
    3. succinate transmembrane transporter activity Source: MGI
    4. tricarboxylic acid transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. citrate transport Source: MGI
    2. succinate transport Source: MGI
    3. tricarboxylic acid transmembrane transport Source: GOC
    4. tricarboxylic acid transport Source: MGI

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 13 member 5
    Alternative name(s):
    Na(+)/citrate cotransporter
    Short name:
    NaCT
    Sodium-coupled citrate transporter
    Sodium-dependent citrate transporter
    Gene namesi
    Name:Slc13a5
    Synonyms:Nact
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:3037150. Slc13a5.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Solute carrier family 13 member 5PRO_0000260102Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ67BT3.
    PRIDEiQ67BT3.

    PTM databases

    PhosphoSiteiQ67BT3.

    Expressioni

    Gene expression databases

    BgeeiQ67BT3.
    GenevestigatoriQ67BT3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000021161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ67BT3.
    SMRiQ67BT3. Positions 41-271, 400-543.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei357 – 37721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei443 – 46321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei532 – 55221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0471.
    GeneTreeiENSGT00550000074480.
    HOGENOMiHOG000278432.
    HOVERGENiHBG055339.
    InParanoidiQ67BT3.
    KOiK14445.
    OMAiIMDSKQV.
    OrthoDBiEOG7G1V5S.
    PhylomeDBiQ67BT3.
    TreeFamiTF312913.

    Family and domain databases

    InterProiIPR001898. Na/sul_symport.
    [Graphical view]
    PfamiPF00939. Na_sulph_symp. 1 hit.
    [Graphical view]
    PROSITEiPS01271. NA_SULFATE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q67BT3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSAKTCVTK FKSFAILLFT PILMLPLVIL IPDKFARCAY VIVIMAVYWC    50
    TDVIPVAVTS LLPVLLFPLL KVLDSKQVCI QYMKDTNMLF LGSLIVAVAV 100
    ERWKLHKRVA LRMLLFVGTK PSRLMLGFMF VTAFLSMWIS NTAATAMMIP 150
    IVEAMLQQMI AANTAVEASL GTLELLDKNK TSELPGSQVV FEDPNVQEQE 200
    DEETKNMYKA MHLCVCYSAS IGGTATLTGT GPNVVLLGQM QELFPDSKDV 250
    LNYASWFGFA FPNMVMMLVL AWLWLQCLYM RHNLKKTCIC CGEKKRDTEK 300
    IAYKVLNEEY QKLGSLSYPE CNVLFCFTLL VILWFSRDPG FMPGWLSFAW 350
    VEGNTVHITD ATVAIFVAIL LFIIPSQKPK FNFSSQTEEE RKTPFYPPAL 400
    LDWKVAQEKV PWDIVLLLGG GFAMAKGCET SGLSKWMAAQ MEPLRLVKPA 450
    VITLILSCLV AMTTECTSNV ATTTLFLPIF ASMARSIGIH PLYVMIPCTM 500
    SASLAFMLPV ATPPNAIVFA YGHLRVVDMM KTGLIMNFVG ILSVFLSVNT 550
    WGRAMFNLDN FPDWANSTSV NT 572
    Length:572
    Mass (Da):63,823
    Last modified:October 11, 2004 - v1
    Checksum:i329C8C48C6624739
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY368893 mRNA. Translation: AAR14317.1.
    AK048662 mRNA. Translation: BAE20664.1.
    AL929071 Genomic DNA. Translation: CAI36028.1.
    CCDSiCCDS24983.1.
    RefSeqiNP_001004148.1. NM_001004148.4.
    UniGeneiMm.340778.

    Genome annotation databases

    EnsembliENSMUST00000021161; ENSMUSP00000021161; ENSMUSG00000020805.
    GeneIDi237831.
    KEGGimmu:237831.
    UCSCiuc007jym.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY368893 mRNA. Translation: AAR14317.1 .
    AK048662 mRNA. Translation: BAE20664.1 .
    AL929071 Genomic DNA. Translation: CAI36028.1 .
    CCDSi CCDS24983.1.
    RefSeqi NP_001004148.1. NM_001004148.4.
    UniGenei Mm.340778.

    3D structure databases

    ProteinModelPortali Q67BT3.
    SMRi Q67BT3. Positions 41-271, 400-543.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000021161.

    PTM databases

    PhosphoSitei Q67BT3.

    Proteomic databases

    PaxDbi Q67BT3.
    PRIDEi Q67BT3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021161 ; ENSMUSP00000021161 ; ENSMUSG00000020805 .
    GeneIDi 237831.
    KEGGi mmu:237831.
    UCSCi uc007jym.2. mouse.

    Organism-specific databases

    CTDi 284111.
    MGIi MGI:3037150. Slc13a5.

    Phylogenomic databases

    eggNOGi COG0471.
    GeneTreei ENSGT00550000074480.
    HOGENOMi HOG000278432.
    HOVERGENi HBG055339.
    InParanoidi Q67BT3.
    KOi K14445.
    OMAi IMDSKQV.
    OrthoDBi EOG7G1V5S.
    PhylomeDBi Q67BT3.
    TreeFami TF312913.

    Miscellaneous databases

    NextBioi 383514.
    PROi Q67BT3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q67BT3.
    Genevestigatori Q67BT3.

    Family and domain databases

    InterProi IPR001898. Na/sul_symport.
    [Graphical view ]
    Pfami PF00939. Na_sulph_symp. 1 hit.
    [Graphical view ]
    PROSITEi PS01271. NA_SULFATE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for citric acid cycle intermediates."
      Inoue K., Fei Y.-J., Zhuang L., Gopal E., Miyauchi S., Ganapathy V.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiS13A5_MOUSE
    AccessioniPrimary (citable) accession number: Q67BT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3