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Q67BT3 (S13A5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 13 member 5
Alternative name(s):
Na(+)/citrate cotransporter
Short name=NaCT
Sodium-coupled citrate transporter
Sodium-dependent citrate transporter
Gene names
Name:Slc13a5
Synonyms:Nact
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Solute carrier family 13 member 5
PRO_0000260102

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane53 – 7321Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane124 – 14421Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane255 – 27521Helical; Potential
Transmembrane315 – 33521Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane410 – 43021Helical; Potential
Transmembrane443 – 46321Helical; Potential
Transmembrane491 – 51121Helical; Potential
Transmembrane532 – 55221Helical; Potential

Amino acid modifications

Glycosylation3821N-linked (GlcNAc...) Potential
Glycosylation5661N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q67BT3 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 329C8C48C6624739

FASTA57263,823
        10         20         30         40         50         60 
MDSAKTCVTK FKSFAILLFT PILMLPLVIL IPDKFARCAY VIVIMAVYWC TDVIPVAVTS 

        70         80         90        100        110        120 
LLPVLLFPLL KVLDSKQVCI QYMKDTNMLF LGSLIVAVAV ERWKLHKRVA LRMLLFVGTK 

       130        140        150        160        170        180 
PSRLMLGFMF VTAFLSMWIS NTAATAMMIP IVEAMLQQMI AANTAVEASL GTLELLDKNK 

       190        200        210        220        230        240 
TSELPGSQVV FEDPNVQEQE DEETKNMYKA MHLCVCYSAS IGGTATLTGT GPNVVLLGQM 

       250        260        270        280        290        300 
QELFPDSKDV LNYASWFGFA FPNMVMMLVL AWLWLQCLYM RHNLKKTCIC CGEKKRDTEK 

       310        320        330        340        350        360 
IAYKVLNEEY QKLGSLSYPE CNVLFCFTLL VILWFSRDPG FMPGWLSFAW VEGNTVHITD 

       370        380        390        400        410        420 
ATVAIFVAIL LFIIPSQKPK FNFSSQTEEE RKTPFYPPAL LDWKVAQEKV PWDIVLLLGG 

       430        440        450        460        470        480 
GFAMAKGCET SGLSKWMAAQ MEPLRLVKPA VITLILSCLV AMTTECTSNV ATTTLFLPIF 

       490        500        510        520        530        540 
ASMARSIGIH PLYVMIPCTM SASLAFMLPV ATPPNAIVFA YGHLRVVDMM KTGLIMNFVG 

       550        560        570 
ILSVFLSVNT WGRAMFNLDN FPDWANSTSV NT 

« Hide

References

« Hide 'large scale' references
[1]"Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for citric acid cycle intermediates."
Inoue K., Fei Y.-J., Zhuang L., Gopal E., Miyauchi S., Ganapathy V.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY368893 mRNA. Translation: AAR14317.1.
AK048662 mRNA. Translation: BAE20664.1.
AL929071 Genomic DNA. Translation: CAI36028.1.
CCDSCCDS24983.1.
RefSeqNP_001004148.1. NM_001004148.4.
UniGeneMm.340778.

3D structure databases

ProteinModelPortalQ67BT3.
SMRQ67BT3. Positions 41-271, 400-543.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000021161.

PTM databases

PhosphoSiteQ67BT3.

Proteomic databases

PaxDbQ67BT3.
PRIDEQ67BT3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021161; ENSMUSP00000021161; ENSMUSG00000020805.
GeneID237831.
KEGGmmu:237831.
UCSCuc007jym.2. mouse.

Organism-specific databases

CTD284111.
MGIMGI:3037150. Slc13a5.

Phylogenomic databases

eggNOGCOG0471.
GeneTreeENSGT00550000074480.
HOGENOMHOG000278432.
HOVERGENHBG055339.
InParanoidQ67BT3.
KOK14445.
OMAIMDSKQV.
OrthoDBEOG7G1V5S.
PhylomeDBQ67BT3.
TreeFamTF312913.

Gene expression databases

BgeeQ67BT3.
GenevestigatorQ67BT3.

Family and domain databases

InterProIPR001898. Na/sul_symport.
[Graphical view]
PfamPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio383514.
PROQ67BT3.
SOURCESearch...

Entry information

Entry nameS13A5_MOUSE
AccessionPrimary (citable) accession number: Q67BT3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot