ID   P19_HARV                Reviewed;         172 AA.
AC   Q67BS9;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=RNA silencing suppressor p19;
DE   AltName: Full=19 kDa symptom severity modulator;
GN   ORFNames=ORF4;
OS   Havel river virus (HaRV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Tolucaviricetes;
OC   Tolivirales; Tombusviridae; Procedovirinae; Tombusvirus;
OC   Tombusvirus havelfluminis.
OX   NCBI_TaxID=254711;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=S;
RX   AGRICOLA=IND43646220; DOI=10.1023/B:EJPP.0000021084.38938.c3;
RA   Koenig R., Pfeilstetter E., Kegler H., Lesemann D.E.;
RT   "Isolation of two strains of a new tombusvirus (Havel river virus, HaRV)
RT   from surface waters in Germany.";
RL   Eur. J. Plant Pathol. 110:429-433(2004).
CC   -!- FUNCTION: Viral suppressor of RNA silencing which binds specifically to
CC       silencing RNAs (siRNAs). Acts as a molecular caliper to specifically
CC       select siRNAs based on the length of the duplex region of the RNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tombusvirus protein p19 family.
CC       {ECO:0000305}.
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DR   EMBL; AY370535; AAR28057.1; -; Genomic_RNA.
DR   SMR; Q67BS9; -.
DR   OrthoDB; 10877at10239; -.
DR   Proteomes; UP000243845; Genome.
DR   GO; GO:0044423; C:virion component; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.390.180; RNA silencing suppressor P19; 1.
DR   InterPro; IPR004905; Tombusvirus_p19.
DR   InterPro; IPR036131; VP19_sf.
DR   Pfam; PF03220; Tombus_P19; 1.
DR   SUPFAM; SSF103145; Tombusvirus P19 core protein, VP19; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   RNA-binding; Suppressor of RNA silencing; Viral immunoevasion.
FT   CHAIN           1..172
FT                   /note="RNA silencing suppressor p19"
FT                   /id="PRO_0000222875"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  19082 MW;  3CD8A5EE4E6D7387 CRC64;
     MEGAIQGSDA REQANSERWD GGCGGTITPF KLPDESPGLH EWRLHNSEES EDKDHPLGFK
     ESWGFGKVVF KRYLRYDGTE ASLHRALGSW ERGSVNDAAS RFLGLGQVGC TYSIRFRGSC
     LTLSGGSRTL QRLIEMAIRT KRTMLQLTPS EVEGNVSRGR PEGAKAFEKE SE
//