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Q676U5

- A16L1_HUMAN

UniProt

Q676U5 - A16L1_HUMAN

Protein

Autophagy-related protein 16-1

Gene

ATG16L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.2 Publications

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagic vacuole assembly Source: UniProtKB
    2. protein homooligomerization Source: UniProtKB
    3. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Enzyme and pathway databases

    SignaLinkiQ676U5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 16-1
    Alternative name(s):
    APG16-like 1
    Gene namesi
    Name:ATG16L1
    Synonyms:APG16L
    ORF Names:UNQ9393/PRO34307
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:21498. ATG16L1.

    Subcellular locationi

    Cytoplasm By similarity. Preautophagosomal structure membrane By similarity; Peripheral membrane protein By similarity
    Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme.By similarity

    GO - Cellular componenti

    1. autophagic vacuole Source: UniProtKB
    2. autophagic vacuole membrane Source: Ensembl
    3. axoneme Source: UniProtKB
    4. pre-autophagosomal structure membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Inflammatory bowel disease 10 (IBD10) [MIM:611081]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti300 – 3001T → A Associated with susceptibility to IBD10; has no effect on the stability of the protein; enhances the cleavage and the degradation mediated by activated CASP3; results in reduced autophagy and defective clearance of intestinal pathogens. 1 Publication
    Corresponds to variant rs2241880 [ dbSNP | Ensembl ].
    VAR_021834

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi299 – 2991D → E: Prevents cleavage by activated CASP3. 1 Publication

    Organism-specific databases

    MIMi611081. phenotype.
    Orphaneti206. Crohn disease.
    PharmGKBiPA134902949.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 607607Autophagy-related protein 16-1PRO_0000050848Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691Phosphoserine1 Publication
    Modified residuei287 – 2871Phosphoserine2 Publications

    Post-translational modificationi

    Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ676U5.
    PaxDbiQ676U5.
    PRIDEiQ676U5.

    PTM databases

    PhosphoSiteiQ676U5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ676U5.
    BgeeiQ676U5.
    CleanExiHS_ATG16L1.
    GenevestigatoriQ676U5.

    Organism-specific databases

    HPAiHPA012577.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa) By similarity. Interacts with RAB33B By similarity. Interacts with TMEM59, TLR2 and NOD2.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-535909,EBI-535909
    GABARAPL2P605202EBI-535909,EBI-720116
    MAP1LC3BQ9GZQ82EBI-535909,EBI-373144
    MAP1LC3CQ9BXW44EBI-535909,EBI-2603996
    RB1CC1Q8TDY25EBI-535909,EBI-1047793
    TMEM59Q9BXS46EBI-535909,EBI-7054441

    Protein-protein interaction databases

    BioGridi120375. 28 interactions.
    DIPiDIP-27552N.
    DIP-50290N.
    IntActiQ676U5. 30 interactions.
    MINTiMINT-1141152.
    STRINGi9606.ENSP00000375872.

    Structurei

    Secondary structure

    1
    607
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 2817
    Helixi30 – 4213

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GDKX-ray2.70C/F11-43[»]
    4GDLX-ray2.88C11-43[»]
    4NAWX-ray2.20C/G/K/O11-43[»]
    ProteinModelPortaliQ676U5.
    SMRiQ676U5. Positions 11-43, 312-604.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati320 – 35940WD 1Add
    BLAST
    Repeati364 – 40340WD 2Add
    BLAST
    Repeati406 – 44540WD 3Add
    BLAST
    Repeati447 – 48438WD 4Add
    BLAST
    Repeati486 – 52540WD 5Add
    BLAST
    Repeati532 – 57342WD 6Add
    BLAST
    Repeati575 – 60733WD 7Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili78 – 230153Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi296 – 2994Caspase cleavage

    Sequence similaritiesi

    Belongs to the WD repeat ATG16 family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000112569.
    HOVERGENiHBG050534.
    KOiK17890.
    OrthoDBiEOG70CR6M.
    PhylomeDBiQ676U5.
    TreeFamiTF315541.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR013923. Autophagy-rel_prot_16.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF08614. ATG16. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q676U5-1) [UniParc]FASTAAdd to Basket

    Also known as: APG16L beta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS    50
    VLAQKLQAEK HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH 100
    KKRGELAQLV IDLNNQMQRK DREMQMNEAK IAECLQTISD LETECLDLRT 150
    KLCDLERANQ TLKDEYDALQ ITFTALEGKL RKTTEENQEL VTRWMAEKAQ 200
    EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI EVIVDETSDH 250
    TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT 300
    HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE 350
    VFGEKCEFKG SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL 400
    RHTLTGHSGK VLSAKFLLDN ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS 450
    SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES IVREMELLGK ITALDLNPER 500
    TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV VFSPDGSYVA 550
    AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK 600
    AVLWAQY 607
    Length:607
    Mass (Da):68,265
    Last modified:April 12, 2005 - v2
    Checksum:i5A5816AE2CF03CA0
    GO
    Isoform 2 (identifier: Q676U5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         266-284: Missing.

    Show »
    Length:588
    Mass (Da):66,296
    Checksum:i168A0E53B2190149
    GO
    Isoform 3 (identifier: Q676U5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         443-470: IKTVFAGSSCNDIVCTEQCVMSGHFDKK → EEIQSLCLCICLDVSVEVCVCTSEPAFM
         471-607: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:470
    Mass (Da):53,220
    Checksum:i7598952D2C1F2A79
    GO
    Isoform 4 (identifier: Q676U5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         70-213: Missing.
         334-368: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:428
    Mass (Da):47,686
    Checksum:iE4F476255CDCA0A7
    GO
    Isoform 5 (identifier: Q676U5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         70-213: Missing.
         266-284: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:444
    Mass (Da):49,486
    Checksum:i7F0FE84A72D619F9
    GO

    Sequence cautioni

    The sequence BAB55412.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511K → R in BAB55412. 1 PublicationCurated
    Sequence conflicti328 – 3281V → A in BAB55412. 1 PublicationCurated
    Sequence conflicti529 – 5291P → T in BAB55412. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti300 – 3001T → A Associated with susceptibility to IBD10; has no effect on the stability of the protein; enhances the cleavage and the degradation mediated by activated CASP3; results in reduced autophagy and defective clearance of intestinal pathogens. 1 Publication
    Corresponds to variant rs2241880 [ dbSNP | Ensembl ].
    VAR_021834
    Natural varianti307 – 3071E → K.
    Corresponds to variant rs1866878 [ dbSNP | Ensembl ].
    VAR_053386

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei70 – 213144Missing in isoform 4 and isoform 5. 2 PublicationsVSP_013389Add
    BLAST
    Alternative sequencei266 – 28419Missing in isoform 2 and isoform 5. 3 PublicationsVSP_013386Add
    BLAST
    Alternative sequencei334 – 36835Missing in isoform 4. 1 PublicationVSP_013390Add
    BLAST
    Alternative sequencei443 – 47028IKTVF…HFDKK → EEIQSLCLCICLDVSVEVCV CTSEPAFM in isoform 3. 1 PublicationVSP_013387Add
    BLAST
    Alternative sequencei471 – 607137Missing in isoform 3. 1 PublicationVSP_013388Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY398617 mRNA. Translation: AAR32130.1.
    EF079889 mRNA. Translation: ABN48554.1.
    EF079890 mRNA. Translation: ABN48555.1.
    AY358182 mRNA. Translation: AAQ88549.1.
    AK026330 mRNA. Translation: BAB15448.1. Sequence problems.
    AK027854 mRNA. Translation: BAB55412.1. Different initiation.
    AK123876 mRNA. Translation: BAC85713.1.
    AC013726 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW71034.1.
    BC071846 mRNA. Translation: AAH71846.1.
    AL834526 mRNA. Translation: CAD39182.1.
    CCDSiCCDS2502.2. [Q676U5-2]
    CCDS2503.2. [Q676U5-1]
    CCDS54438.1. [Q676U5-5]
    RefSeqiNP_001177195.1. NM_001190266.1.
    NP_001177196.1. NM_001190267.1.
    NP_060444.3. NM_017974.3. [Q676U5-2]
    NP_110430.5. NM_030803.6. [Q676U5-1]
    NP_942593.2. NM_198890.2. [Q676U5-5]
    UniGeneiHs.529322.

    Genome annotation databases

    EnsembliENST00000347464; ENSP00000318259; ENSG00000085978. [Q676U5-5]
    ENST00000373525; ENSP00000362625; ENSG00000085978. [Q676U5-4]
    ENST00000392017; ENSP00000375872; ENSG00000085978. [Q676U5-1]
    ENST00000392020; ENSP00000375875; ENSG00000085978. [Q676U5-2]
    GeneIDi55054.
    KEGGihsa:55054.
    UCSCiuc002vtx.2. human. [Q676U5-5]
    uc002vty.3. human. [Q676U5-1]
    uc002vtz.3. human. [Q676U5-4]
    uc002vua.3. human. [Q676U5-2]

    Polymorphism databases

    DMDMi62510482.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY398617 mRNA. Translation: AAR32130.1 .
    EF079889 mRNA. Translation: ABN48554.1 .
    EF079890 mRNA. Translation: ABN48555.1 .
    AY358182 mRNA. Translation: AAQ88549.1 .
    AK026330 mRNA. Translation: BAB15448.1 . Sequence problems.
    AK027854 mRNA. Translation: BAB55412.1 . Different initiation.
    AK123876 mRNA. Translation: BAC85713.1 .
    AC013726 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW71034.1 .
    BC071846 mRNA. Translation: AAH71846.1 .
    AL834526 mRNA. Translation: CAD39182.1 .
    CCDSi CCDS2502.2. [Q676U5-2 ]
    CCDS2503.2. [Q676U5-1 ]
    CCDS54438.1. [Q676U5-5 ]
    RefSeqi NP_001177195.1. NM_001190266.1.
    NP_001177196.1. NM_001190267.1.
    NP_060444.3. NM_017974.3. [Q676U5-2 ]
    NP_110430.5. NM_030803.6. [Q676U5-1 ]
    NP_942593.2. NM_198890.2. [Q676U5-5 ]
    UniGenei Hs.529322.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GDK X-ray 2.70 C/F 11-43 [» ]
    4GDL X-ray 2.88 C 11-43 [» ]
    4NAW X-ray 2.20 C/G/K/O 11-43 [» ]
    ProteinModelPortali Q676U5.
    SMRi Q676U5. Positions 11-43, 312-604.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120375. 28 interactions.
    DIPi DIP-27552N.
    DIP-50290N.
    IntActi Q676U5. 30 interactions.
    MINTi MINT-1141152.
    STRINGi 9606.ENSP00000375872.

    PTM databases

    PhosphoSitei Q676U5.

    Polymorphism databases

    DMDMi 62510482.

    Proteomic databases

    MaxQBi Q676U5.
    PaxDbi Q676U5.
    PRIDEi Q676U5.

    Protocols and materials databases

    DNASUi 55054.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347464 ; ENSP00000318259 ; ENSG00000085978 . [Q676U5-5 ]
    ENST00000373525 ; ENSP00000362625 ; ENSG00000085978 . [Q676U5-4 ]
    ENST00000392017 ; ENSP00000375872 ; ENSG00000085978 . [Q676U5-1 ]
    ENST00000392020 ; ENSP00000375875 ; ENSG00000085978 . [Q676U5-2 ]
    GeneIDi 55054.
    KEGGi hsa:55054.
    UCSCi uc002vtx.2. human. [Q676U5-5 ]
    uc002vty.3. human. [Q676U5-1 ]
    uc002vtz.3. human. [Q676U5-4 ]
    uc002vua.3. human. [Q676U5-2 ]

    Organism-specific databases

    CTDi 55054.
    GeneCardsi GC02P234118.
    HGNCi HGNC:21498. ATG16L1.
    HPAi HPA012577.
    MIMi 610767. gene.
    611081. phenotype.
    neXtProti NX_Q676U5.
    Orphaneti 206. Crohn disease.
    PharmGKBi PA134902949.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000112569.
    HOVERGENi HBG050534.
    KOi K17890.
    OrthoDBi EOG70CR6M.
    PhylomeDBi Q676U5.
    TreeFami TF315541.

    Enzyme and pathway databases

    SignaLinki Q676U5.

    Miscellaneous databases

    GeneWikii ATG16L1.
    GenomeRNAii 55054.
    NextBioi 58531.
    PROi Q676U5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q676U5.
    Bgeei Q676U5.
    CleanExi HS_ATG16L1.
    Genevestigatori Q676U5.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR013923. Autophagy-rel_prot_16.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF08614. ATG16. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-300.
      Tissue: Fetal brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), ASSOCIATION OF VARIANT ALA-300 WITH SUSCEPTIBILITY TO IBD10.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-607 (ISOFORM 2).
      Tissue: Brain, Placenta and Small intestine.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-607 (ISOFORM 2).
      Tissue: Mammary gland.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 513-607.
      Tissue: Testis.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269 AND SER-287, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3."
      Boada-Romero E., Letek M., Fleischer A., Pallauf K., Ramon-Barros C., Pimentel-Muinos F.X.
      EMBO J. 32:566-582(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TMEM59; TLR2 AND NOD2.
    12. Cited for: ASSOCIATION OF VARIANT ALA-300 WITH SUSCEPTIBILITY TO IBD10.
    13. Cited for: FUNCTION IN AUTOPHAGY, CLEAVAGE BY CASP3, CHARACTERIZATION OF VARIANT ALA-300, MUTAGENESIS OF ASP-299.

    Entry informationi

    Entry nameiA16L1_HUMAN
    AccessioniPrimary (citable) accession number: Q676U5
    Secondary accession number(s): A3EXK9
    , A3EXL0, B6ZDH0, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3