Q676U5 (A16L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy-related protein 16-1

Alternative name(s):
APG16-like 1

Gene names

Name:	ATG16L1
Synonyms:	APG16L
ORF Names:	UNQ9393/PRO34307

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	607 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Ref.11
Subunit structure	Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa) By similarity. Interacts with RAB33B By similarity. Interacts with TMEM59, TLR2 and NOD2. Ref.11
Subcellular location	Cytoplasm By similarity. Preautophagosomal structure membrane; Peripheral membrane protein By similarity. Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 By similarity.
Involvement in disease	Inflammatory bowel disease 10 (IBD10) [MIM:611081]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.2 Ref.12
Sequence similarities	Belongs to the WD repeat ATG16 family. Contains 7 WD repeats.
Sequence caution	The sequence BAB15448.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence BAB55412.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat WD repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	autophagic vacuole assembly Non-traceable author statement Ref.1. Source: UniProtKB protein homooligomerization Non-traceable author statement Ref.1. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	autophagic vacuole Inferred from sequence or structural similarity Ref.1. Source: UniProtKB autophagic vacuole membrane Inferred from electronic annotation. Source: Compara pre-autophagosomal structure membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GABARAPL2	P60520	2	EBI-535909,EBI-720116
MAP1LC3B	Q9GZQ8	2	EBI-535909,EBI-373144
MAP1LC3C	Q9BXW4	4	EBI-535909,EBI-2603996

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q676U5-1)

Also known as: APG16L beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q676U5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     266-284: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 3 (identifier: Q676U5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     443-470: IKTVFAGSSCNDIVCTEQCVMSGHFDKK → EEIQSLCLCICLDVSVEVCVCTSEPAFM
     471-607: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q676U5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     70-213: Missing.
     334-368: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q676U5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     70-213: Missing.
     266-284: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 607

607

Autophagy-related protein 16-1

PRO_0000050848

Regions

Repeat

320 – 359

40

WD 1

Repeat

364 – 403

40

WD 2

Repeat

406 – 445

40

WD 3

Repeat

447 – 484

38

WD 4

Repeat

486 – 525

40

WD 5

Repeat

532 – 573

42

WD 6

Repeat

575 – 607

33

WD 7

Coiled coil

78 – 230

153

Potential

Amino acid modifications

Modified residue

269

1

Phosphoserine Ref.10

Modified residue

287

1

Phosphoserine Ref.9 Ref.10

Modified residue

289

1

Phosphoserine By similarity

Natural variations

Alternative sequence

70 – 213

144

Missing in isoform 4 and isoform 5.

VSP_013389

Alternative sequence

266 – 284

19

Missing in isoform 2 and isoform 5.

VSP_013386

Alternative sequence

334 – 368

35

Missing in isoform 4.

VSP_013390

Alternative sequence

443 – 470

28

IKTVF…HFDKK → EEIQSLCLCICLDVSVEVCV CTSEPAFM in isoform 3.

VSP_013387

Alternative sequence

471 – 607

137

Missing in isoform 3.

VSP_013388

Natural variant

300

1

T → A Associated with susceptibility to IBD10. Ref.1 Ref.2 Ref.12
Corresponds to variant rs2241880 [ dbSNP | Ensembl ].

VAR_021834

Natural variant

307

1

E → K.
Corresponds to variant rs1866878 [ dbSNP | Ensembl ].

VAR_053386

Experimental info

Sequence conflict

151

1

K → R in BAB55412. Ref.6

Sequence conflict

328

1

V → A in BAB55412. Ref.6

Sequence conflict

529

1

P → T in BAB55412. Ref.6

Secondary structure

1

.

.

.

.

.

607

Helix Strand Turn

Details...

Helix

12 – 28

17

Helix

30 – 41

12

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (APG16L beta) [UniParc]. Last modified April 12, 2005. Version 2. Checksum: 5A5816AE2CF03CA0	FASTA	607	68,265
	10 20 30 40 50 60 MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK 70 80 90 100 110 120 HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK 130 140 150 160 170 180 DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL 190 200 210 220 230 240 RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI 250 260 270 280 290 300 EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT 310 320 330 340 350 360 HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG 370 380 390 400 410 420 SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN 430 440 450 460 470 480 ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES 490 500 510 520 530 540 IVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV 550 560 570 580 590 600 VFSPDGSYVA AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK AVLWAQY
	Isoform 2 [UniParc]. Checksum: 168A0E53B2190149	FASTA	588	66,296
	10 20 30 40 50 60 MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK 70 80 90 100 110 120 HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK 130 140 150 160 170 180 DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL 190 200 210 220 230 240 RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI 250 260 270 280 290 300 EVIVDETSDH TEETSPVRAI SRAATRRSVS SFPVPQDNVD THPGSGKEVR VPATALCVFD 310 320 330 340 350 360 AHDGEVNAVQ FSPGSRLLAT GGMDRRVKLW EVFGEKCEFK GSLSGSNAGI TSIEFDSAGS 370 380 390 400 410 420 YLLAASNDFA SRIWTVDDYR LRHTLTGHSG KVLSAKFLLD NARIVSGSHD RTLKLWDLRS 430 440 450 460 470 480 KVCIKTVFAG SSCNDIVCTE QCVMSGHFDK KIRFWDIRSE SIVREMELLG KITALDLNPE 490 500 510 520 530 540 RTELLSCSRD DLLKVIDLRT NAIKQTFSAP GFKCGSDWTR VVFSPDGSYV AAGSAEGSLY 550 560 570 580 IWSVLTGKVE KVLSKQHSSS INAVAWSPSG SHVVSVDKGC KAVLWAQY
	Isoform 3 [UniParc]. Checksum: 7598952D2C1F2A79	FASTA	470	53,220
	10 20 30 40 50 60 MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK 70 80 90 100 110 120 HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK 130 140 150 160 170 180 DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL 190 200 210 220 230 240 RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI 250 260 270 280 290 300 EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT 310 320 330 340 350 360 HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG 370 380 390 400 410 420 SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN 430 440 450 460 470 ARIVSGSHDR TLKLWDLRSK VCEEIQSLCL CICLDVSVEV CVCTSEPAFM
	Isoform 4 [UniParc]. Checksum: E4F476255CDCA0A7	FASTA	428	47,686
	10 20 30 40 50 60 MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK 70 80 90 100 110 120 HDVPNRHEIR RRQARLQKEL AEAAKEPLPV EQDDDIEVIV DETSDHTEET SPVRAISRAA 130 140 150 160 170 180 TKRLSQPAGG LLDSITNIFG RRSVSSFPVP QDNVDTHPGS GKEVRVPATA LCVFDAHDGE 190 200 210 220 230 240 VNAVQFSPGI TSIEFDSAGS YLLAASNDFA SRIWTVDDYR LRHTLTGHSG KVLSAKFLLD 250 260 270 280 290 300 NARIVSGSHD RTLKLWDLRS KVCIKTVFAG SSCNDIVCTE QCVMSGHFDK KIRFWDIRSE 310 320 330 340 350 360 SIVREMELLG KITALDLNPE RTELLSCSRD DLLKVIDLRT NAIKQTFSAP GFKCGSDWTR 370 380 390 400 410 420 VVFSPDGSYV AAGSAEGSLY IWSVLTGKVE KVLSKQHSSS INAVAWSPSG SHVVSVDKGC KAVLWAQY
	Isoform 5 [UniParc]. Checksum: 7F0FE84A72D619F9	FASTA	444	49,486
	10 20 30 40 50 60 MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK 70 80 90 100 110 120 HDVPNRHEIR RRQARLQKEL AEAAKEPLPV EQDDDIEVIV DETSDHTEET SPVRAISRAA 130 140 150 160 170 180 TRRSVSSFPV PQDNVDTHPG SGKEVRVPAT ALCVFDAHDG EVNAVQFSPG SRLLATGGMD 190 200 210 220 230 240 RRVKLWEVFG EKCEFKGSLS GSNAGITSIE FDSAGSYLLA ASNDFASRIW TVDDYRLRHT 250 260 270 280 290 300 LTGHSGKVLS AKFLLDNARI VSGSHDRTLK LWDLRSKVCI KTVFAGSSCN DIVCTEQCVM 310 320 330 340 350 360 SGHFDKKIRF WDIRSESIVR EMELLGKITA LDLNPERTEL LSCSRDDLLK VIDLRTNAIK 370 380 390 400 410 420 QTFSAPGFKC GSDWTRVVFS PDGSYVAAGS AEGSLYIWSV LTGKVEKVLS KQHSSSINAV 430 440 AWSPSGSHVV SVDKGCKAVL WAQY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and analysis of human Apg16L." Zheng H., Ji C., Li J., Jiang H., Ren M., Lu Q., Gu S., Mao Y., Xie Y. DNA Seq. 15:303-305(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-300. Tissue: Fetal brain.
[2]	"A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1." Hampe J., Franke A., Rosenstiel P., Till A., Teuber M., Huse K., Albrecht M., Mayr G., De La Vega F.M., Briggs J., Guenther S., Prescott N.J., Onnie C.M., Haesler R., Sipos B., Foelsch U.R., Lengauer T., Platzer M. , Mathew C.G., Krawczak M., Schreiber S. Nat. Genet. 39:207-211(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), ASSOCIATION OF VARIANT ALA-300 WITH SUSCEPTIBILITY TO IBD10.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-607 (ISOFORM 2). Tissue: Brain, Placenta and Small intestine.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-607 (ISOFORM 2). Tissue: Mammary gland.
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 513-607. Tissue: Testis.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269 AND SER-287, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3." Boada-Romero E., Letek M., Fleischer A., Pallauf K., Ramon-Barros C., Pimentel-Muinos F.X. EMBO J. 32:566-582(2013) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH TMEM59; TLR2 AND NOD2.
[12]	"Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis." Rioux J.D., Xavier R.J., Taylor K.D., Silverberg M.S., Goyette P., Huett A., Green T., Kuballa P., Barmada M.M., Datta L.W., Shugart Y.Y., Griffiths A.M., Targan S.R., Ippoliti A.F., Bernard E.-J., Mei L., Nicolae D.L., Regueiro M. , Schumm L.P., Steinhart A.H., Rotter J.I., Duerr R.H., Cho J.H., Daly M.J., Brant S.R. Nat. Genet. 39:596-604(2007) [PubMed] [Europe PMC] [Abstract] Cited for: ASSOCIATION OF VARIANT ALA-300 WITH SUSCEPTIBILITY TO IBD10.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY398617 mRNA. Translation: AAR32130.1.
EF079889 mRNA. Translation: ABN48554.1.
EF079890 mRNA. Translation: ABN48555.1.
AY358182 mRNA. Translation: AAQ88549.1.
AK026330 mRNA. Translation: BAB15448.1. Sequence problems.
AK027854 mRNA. Translation: BAB55412.1. Different initiation.
AK123876 mRNA. Translation: BAC85713.1.
AC013726 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW71034.1.
BC071846 mRNA. Translation: AAH71846.1.
AL834526 mRNA. Translation: CAD39182.1.

IPI

IPI00432751.
IPI00446614.
IPI00470446.
IPI00555905.
IPI00797150.

RefSeq

NP_001177195.1. NM_001190266.1.
NP_001177196.1. NM_001190267.1.
NP_060444.3. NM_017974.3.
NP_110430.5. NM_030803.6.
NP_942593.2. NM_198890.2.

UniGene

Hs.529322.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4GDK	X-ray	2.70	C/F	11-43	[»]
4GDL	X-ray	2.88	C	11-43	[»]

ProteinModelPortal

Q676U5.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-27552N.

IntAct

Q676U5. 19 interactions.

MINT

MINT-1141152.

STRING

9606.ENSP00000375872.

PTM databases

PhosphoSite

Q676U5.

Polymorphism databases

DMDM

62510482.

Proteomic databases

PaxDb

Q676U5.

PRIDE

Q676U5.

Protocols and materials databases

DNASU

55054.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000347464; ENSP00000318259; ENSG00000085978.
ENST00000373525; ENSP00000362625; ENSG00000085978.
ENST00000392017; ENSP00000375872; ENSG00000085978.
ENST00000392020; ENSP00000375875; ENSG00000085978.

GeneID

55054.

KEGG

hsa:55054.

UCSC

uc002vty.3. human.
uc002vtz.3. human.
uc002vua.3. human.

Organism-specific databases

CTD

55054.

GeneCards

GC02P234118.

HGNC

HGNC:21498. ATG16L1.

HPA

HPA012577.

MIM

610767. gene.
611081. phenotype.

neXtProt

NX_Q676U5.

Orphanet

206. Crohn disease.

PharmGKB

PA134902949.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG2319.

HOGENOM

HOG000112569.

HOVERGEN

HBG050534.

OrthoDB

EOG4SXNC8.

Gene expression databases

ArrayExpress

Q676U5.

Bgee

Q676U5.

CleanEx

HS_ATG16L1.

Genevestigator

Q676U5.

GermOnline

ENSG00000085978. Homo sapiens.

Family and domain databases

Gene3D

2.130.10.10. 1 hit.

InterPro

IPR013923. Autophagy-rel_prot_16.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]

Pfam

PF08614. ATG16. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]

PRINTS

PR00320. GPROTEINBRPT.

SMART

SM00320. WD40. 7 hits.
[Graphical view]

SUPFAM

SSF50978. WD40_like. 1 hit.

PROSITE

PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

55054.

NextBio

58531.

SOURCE

Search...

Entry information

Entry name

A16L1_HUMAN

Accession

Primary (citable) accession number: Q676U5
Secondary accession number(s): A3EXK9 , A3EXL0, B6ZDH0, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	April 12, 2005
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.