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Protein

Replication enhancer protein

Gene

C3

Organism
Tomato yellow leaf curl Sardinia virus (isolate Spain-2) (TYLCSV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Increases viral DNA accumulation. Enhances infectivity and symptom expression (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Replication enhancer protein
Short name:
REn
Alternative name(s):
Protein C3
Protein L3
Gene namesi
ORF Names:C3, L3
OrganismiTomato yellow leaf curl Sardinia virus (isolate Spain-2) (TYLCSV)
Taxonomic identifieri221538 [NCBI]
Taxonomic lineageiVirusesssDNA virusesGeminiviridaeBegomovirus
Virus hostiCynanchum acutum [TaxID: 185024]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum nigrum (Black nightshade) [TaxID: 4112]
Proteomesi
  • UP000008266 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003236841 – 134Replication enhancer proteinAdd BLAST134

Interactioni

Subunit structurei

Homooligomer. Interacts with the replication-associated protein (REP). Interacts with host proliferating cell nuclear antigen (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1), and may thereby deregulate the host cell cycle. Oligomerization and interaction with PCNA are necessary for optimal replication enhancement (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000657. Gemini_AL3.
[Graphical view]
PfamiPF01407. Gemini_AL3. 1 hit.
[Graphical view]
PRINTSiPR00231. GEMCOATAL3.
ProDomiPD001172. Gemini_AL3. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q67618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRTGEYIT AHQATSGVYT FEITNPLYFT ITRHNQQPFN SKYNLLTFQI
60 70 80 90 100
RFNHNLRKAL GIHKCFLNFR IWTTLQSPTG HFLRVFRFQV YKYLNNIGVI
110 120 130
SLNNVIRAVD YVLFDVFENT IDVIEQHEIK YNLY
Length:134
Mass (Da):16,016
Last modified:November 1, 1996 - v1
Checksum:i82BEA183BE731234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27708 Genomic DNA. Translation: AAA47953.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27708 Genomic DNA. Translation: AAA47953.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000657. Gemini_AL3.
[Graphical view]
PfamiPF01407. Gemini_AL3. 1 hit.
[Graphical view]
PRINTSiPR00231. GEMCOATAL3.
ProDomiPD001172. Gemini_AL3. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiREN_TYCS2
AccessioniPrimary (citable) accession number: Q67618
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.