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Protein

Kazrin

Gene

KAZN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Kazrin
Gene namesi
Name:KAZN
Synonyms:KAZ, KIAA1026
ORF Names:HRIHFB2003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29173. KAZN.

Subcellular locationi

Isoform 2 :
  • Cytoplasm
  • Cell junctiondesmosome
  • Nucleus

  • Note: Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.
Isoform 3 :
  • Cytoplasm
  • Cell junctiondesmosome
  • Nucleus

  • Note: Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.
Isoform 4 :
  • Cytoplasm
  • Cell junctiondesmosome
  • Nucleus

  • Note: Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.

GO - Cellular componenti

  • cornified envelope Source: MGI
  • cytoplasm Source: UniProtKB-SubCell
  • cytoskeleton Source: UniProtKB-SubCell
  • desmosome Source: MGI
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiKAZN.
DMDMi172044653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 775775KazrinPRO_0000322453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei352 – 3521PhosphoserineBy similarity
Modified residuei367 – 3671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ674X7.
MaxQBiQ674X7.
PaxDbiQ674X7.
PRIDEiQ674X7.

PTM databases

iPTMnetiQ674X7.
PhosphoSiteiQ674X7.

Expressioni

Tissue specificityi

Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicular epidermis (at protein level).1 Publication

Gene expression databases

BgeeiQ674X7.
ExpressionAtlasiQ674X7. baseline and differential.
GenevisibleiQ674X7. HS.

Organism-specific databases

HPAiHPA032095.
HPA032096.

Interactioni

Subunit structurei

Isoform 2, isoform 3 and isoform 4 interact with PPL N-terminus.

Binary interactionsi

WithEntry#Exp.IntActNotes
LZTS2Q9BRK43EBI-949239,EBI-741037

Protein-protein interaction databases

BioGridi116858. 4 interactions.
IntActiQ674X7. 3 interactions.
STRINGi9606.ENSP00000365198.

Structurei

3D structure databases

ProteinModelPortaliQ674X7.
SMRiQ674X7. Positions 442-672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini446 – 51166SAM 1PROSITE-ProRule annotationAdd
BLAST
Domaini524 – 58865SAM 2PROSITE-ProRule annotationAdd
BLAST
Domaini612 – 67968SAM 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 333160Interaction with PPLAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili74 – 256183Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi375 – 3828Poly-Lys

Sequence similaritiesi

Belongs to the kazrin family.Curated
Contains 3 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0249. Eukaryota.
ENOG410XP8Z. LUCA.
GeneTreeiENSGT00760000119138.
HOVERGENiHBG058718.
InParanoidiQ674X7.
OMAiKAWLSDV.
OrthoDBiEOG78SQH9.
PhylomeDBiQ674X7.
TreeFamiTF331216.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 3 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 3 hits.
PROSITEiPS50105. SAM_DOMAIN. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q674X7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEDNKQLAL RIDGAVQSAS QEVTNLRAEL TATNRRLAEL SGGGGPGPGP
60 70 80 90 100
GAAASASAAG DSAATNMENP QLGAQVLLRE EVSRLQEEVH LLRQMKEMLA
110 120 130 140 150
KDLEESQGGK SSEVLSATEL RVQLAQKEQE LARAKEALQA MKADRKRLKG
160 170 180 190 200
EKTDLVSQMQ QLYATLESRE EQLRDFIRNY EQHRKESEDA VKALAKEKDL
210 220 230 240 250
LEREKWELRR QAKEATDHAT ALRSQLDLKD NRMKELEAEL AMAKQSLATL
260 270 280 290 300
TKDVPKRHSL AMPGETVLNG NQEWVVQADL PLTAAIRQSQ QTLYHSHPPH
310 320 330 340 350
PADRQAVRVS PCHSRQPSVI SDASAAEGDR SSTPSDINSP RHRTHSLCNG
360 370 380 390 400
DSPGPVQKNL HNPIVQSLED LEDQKRKKKK EKMGFGSISR VFARGKQRKS
410 420 430 440 450
LDPGLFDDSD SQCSPTRQSL SLSEGEEQMD RLQQVELVRT TPMSHWKAGT
460 470 480 490 500
VQAWLEVVMA MPMYVKACTE NVKSGKVLLS LSDEDLQLGL GVCSSLHRRK
510 520 530 540 550
LRLAIEDYRD AEAGRSLSKA AELDHHWVAK AWLNDIGLSQ YSQAFQNHLV
560 570 580 590 600
DGRMLNSLMK RDLEKHLNVS KKFHQVSILL GIELLYQVNF SREALQERRA
610 620 630 640 650
RCETQNIDPV VWTNQRVLKW VRDIDLKEYA DNLTNSGVHG AVLVLEPTFN
660 670 680 690 700
AEAMATALGI PSGKHILRRH LAEEMSAVFH PANSTGIREA ERFGTPPGRA
710 720 730 740 750
SSVTRAGKEE NSSGLKYKAG RLPLGKIGRG FSSKDPDFHD DYGSLQNEDC
760 770
GDDDPQSRLE QCRLEGYNSL EVTNV
Length:775
Mass (Da):86,351
Last modified:February 26, 2008 - v2
Checksum:i7A13B7F262C79294
GO
Isoform 2 (identifier: Q674X7-2) [UniParc]FASTAAdd to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     408-422: DSDSQCSPTRQSLSL → GTAPDYYIEEDADW
     423-775: Missing.

Show »
Length:421
Mass (Da):46,766
Checksum:i977131CDD2E6526F
GO
Isoform 3 (identifier: Q674X7-3) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: MMEDNKQLAL...NMENPQLGAQ → MRAADSGSWE...VRADGDCSQP
     408-422: DSDSQCSPTRQSLSL → GTAPDYYIEEDADW
     423-775: Missing.

Show »
Length:415
Mass (Da):46,212
Checksum:i53ECA06BE458B5C4
GO
Isoform 4 (identifier: Q674X7-4) [UniParc]FASTAAdd to basket

Also known as: C, D

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     408-422: DSDSQCSPTRQSLSL → GTAPDYYIEEDADW
     423-775: Missing.

Show »
Length:327
Mass (Da):37,034
Checksum:iAFDE5259EB272437
GO
Isoform 5 (identifier: Q674X7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-421: GDSPGPVQKN...QCSPTRQSLS → VRPAAAGPGP...RPVCSLCPGG
     422-775: Missing.

Show »
Length:421
Mass (Da):46,250
Checksum:i5400415BC04E3FBE
GO

Sequence cautioni

The sequence AAH36877.1 differs from that shown.The cDNA sequence has been translated in the reverse direction.Curated
The sequence AAI01638.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI13622.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA82978.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA88115.1 differs from that shown. Reason: Frameshift at position 348. Curated
The sequence BAC86294.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti348 – 3492CN → S in BAA88115 (PubMed:9853615).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti706 – 7061A → T.1 Publication
Corresponds to variant rs10803354 [ dbSNP | Ensembl ].
VAR_060168
Natural varianti763 – 7631R → C.
Corresponds to variant rs12048768 [ dbSNP | Ensembl ].
VAR_060169

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 4. 2 PublicationsVSP_031898Add
BLAST
Alternative sequencei1 – 7575MMEDN…QLGAQ → MRAADSGSWERVRQLAAQGE PAPSCGAGAGPARPPGPAAC EQCVDAAGPGDRPRAGVPRV RADGDCSQP in isoform 3. 2 PublicationsVSP_031899Add
BLAST
Alternative sequencei350 – 42172GDSPG…RQSLS → VRPAAAGPGPLGPAQKLQGR GWRGEAILAVSSRPPREHSG ECISCSVLSFCKKRWMWGEK GMRPVCSLCPGG in isoform 5. 1 PublicationVSP_031900Add
BLAST
Alternative sequencei408 – 42215DSDSQ…QSLSL → GTAPDYYIEEDADW in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_031901Add
BLAST
Alternative sequencei422 – 775354Missing in isoform 5. 1 PublicationVSP_031902Add
BLAST
Alternative sequencei423 – 775353Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_031903Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY505119 mRNA. Translation: AAS86434.1.
AY505120 mRNA. Translation: AAS86435.1.
AY505121 mRNA. Translation: AAS86436.1.
AY505122 mRNA. Translation: AAS86437.1.
AB028949 mRNA. Translation: BAA82978.1. Different initiation.
AL034395, AL035405, AL391215 Genomic DNA. Translation: CAQ08073.1.
AL035405, AL391215 Genomic DNA. Translation: CAI19827.1.
AL035405, AL034395, AL391215 Genomic DNA. Translation: CAQ07837.1.
AL391215, AL035405 Genomic DNA. Translation: CAI13899.1.
AL391215, AL034395, AL035405 Genomic DNA. Translation: CAQ06787.1.
CH471167 Genomic DNA. Translation: EAW51704.1.
BC035501 mRNA. Translation: AAH35501.3.
BC036877 mRNA. Translation: AAH36877.1. Sequence problems.
BC101637 mRNA. Translation: AAI01638.1. Different initiation.
BC113621 mRNA. Translation: AAI13622.1. Different initiation.
AB015329 mRNA. Translation: BAA88115.1. Frameshift.
AK125794 mRNA. Translation: BAC86294.1. Different initiation.
CCDSiCCDS152.2. [Q674X7-1]
CCDS30604.1. [Q674X7-3]
CCDS41267.1. [Q674X7-2]
CCDS41268.1. [Q674X7-4]
RefSeqiNP_001017999.1. NM_001017999.2. [Q674X7-4]
NP_001018000.1. NM_001018000.3. [Q674X7-3]
NP_001018001.1. NM_001018001.2. [Q674X7-4]
NP_056024.1. NM_015209.2. [Q674X7-2]
NP_963922.2. NM_201628.2. [Q674X7-1]
UniGeneiHs.368823.

Genome annotation databases

EnsembliENST00000361144; ENSP00000354727; ENSG00000189337. [Q674X7-3]
ENST00000376030; ENSP00000365198; ENSG00000189337. [Q674X7-1]
ENST00000400797; ENSP00000383601; ENSG00000189337. [Q674X7-4]
ENST00000400798; ENSP00000383602; ENSG00000189337. [Q674X7-4]
ENST00000503743; ENSP00000426015; ENSG00000189337. [Q674X7-2]
GeneIDi23254.
KEGGihsa:23254.
UCSCiuc001avm.5. human. [Q674X7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY505119 mRNA. Translation: AAS86434.1.
AY505120 mRNA. Translation: AAS86435.1.
AY505121 mRNA. Translation: AAS86436.1.
AY505122 mRNA. Translation: AAS86437.1.
AB028949 mRNA. Translation: BAA82978.1. Different initiation.
AL034395, AL035405, AL391215 Genomic DNA. Translation: CAQ08073.1.
AL035405, AL391215 Genomic DNA. Translation: CAI19827.1.
AL035405, AL034395, AL391215 Genomic DNA. Translation: CAQ07837.1.
AL391215, AL035405 Genomic DNA. Translation: CAI13899.1.
AL391215, AL034395, AL035405 Genomic DNA. Translation: CAQ06787.1.
CH471167 Genomic DNA. Translation: EAW51704.1.
BC035501 mRNA. Translation: AAH35501.3.
BC036877 mRNA. Translation: AAH36877.1. Sequence problems.
BC101637 mRNA. Translation: AAI01638.1. Different initiation.
BC113621 mRNA. Translation: AAI13622.1. Different initiation.
AB015329 mRNA. Translation: BAA88115.1. Frameshift.
AK125794 mRNA. Translation: BAC86294.1. Different initiation.
CCDSiCCDS152.2. [Q674X7-1]
CCDS30604.1. [Q674X7-3]
CCDS41267.1. [Q674X7-2]
CCDS41268.1. [Q674X7-4]
RefSeqiNP_001017999.1. NM_001017999.2. [Q674X7-4]
NP_001018000.1. NM_001018000.3. [Q674X7-3]
NP_001018001.1. NM_001018001.2. [Q674X7-4]
NP_056024.1. NM_015209.2. [Q674X7-2]
NP_963922.2. NM_201628.2. [Q674X7-1]
UniGeneiHs.368823.

3D structure databases

ProteinModelPortaliQ674X7.
SMRiQ674X7. Positions 442-672.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116858. 4 interactions.
IntActiQ674X7. 3 interactions.
STRINGi9606.ENSP00000365198.

PTM databases

iPTMnetiQ674X7.
PhosphoSiteiQ674X7.

Polymorphism and mutation databases

BioMutaiKAZN.
DMDMi172044653.

Proteomic databases

EPDiQ674X7.
MaxQBiQ674X7.
PaxDbiQ674X7.
PRIDEiQ674X7.

Protocols and materials databases

DNASUi23254.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361144; ENSP00000354727; ENSG00000189337. [Q674X7-3]
ENST00000376030; ENSP00000365198; ENSG00000189337. [Q674X7-1]
ENST00000400797; ENSP00000383601; ENSG00000189337. [Q674X7-4]
ENST00000400798; ENSP00000383602; ENSG00000189337. [Q674X7-4]
ENST00000503743; ENSP00000426015; ENSG00000189337. [Q674X7-2]
GeneIDi23254.
KEGGihsa:23254.
UCSCiuc001avm.5. human. [Q674X7-1]

Organism-specific databases

CTDi23254.
GeneCardsiKAZN.
H-InvDBHIX0000144.
HGNCiHGNC:29173. KAZN.
HPAiHPA032095.
HPA032096.
neXtProtiNX_Q674X7.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0249. Eukaryota.
ENOG410XP8Z. LUCA.
GeneTreeiENSGT00760000119138.
HOVERGENiHBG058718.
InParanoidiQ674X7.
OMAiKAWLSDV.
OrthoDBiEOG78SQH9.
PhylomeDBiQ674X7.
TreeFamiTF331216.

Miscellaneous databases

ChiTaRSiKAZN. human.
GenomeRNAii23254.
NextBioi44969.
PROiQ674X7.

Gene expression databases

BgeeiQ674X7.
ExpressionAtlasiQ674X7. baseline and differential.
GenevisibleiQ674X7. HS.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00536. SAM_1. 2 hits.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 3 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 3 hits.
PROSITEiPS50105. SAM_DOMAIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane."
    Groot K.R., Sevilla L.M., Nishi K., DiColandrea T., Watt F.M.
    J. Cell Biol. 166:653-659(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH PPL.
    Tissue: Spinal ganglion.
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Uterus.
  6. "Selection system for genes encoding nuclear-targeted proteins."
    Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
    Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-775 (ISOFORM 4), SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 536-775 (ISOFORM 1), VARIANT THR-706.
    Tissue: Testis.

Entry informationi

Entry nameiKAZRN_HUMAN
AccessioniPrimary (citable) accession number: Q674X7
Secondary accession number(s): B0QYQ0
, B1AK78, Q5TGF1, Q674X4, Q674X6, Q6ZUD1, Q8IYN7, Q8N409, Q9UIL2, Q9UPX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 13, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.