Q67472 (DNMT_FRG3G) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative DNA (cytosine-5)-methyltransferase
EC=2.1.1.37

Gene names

ORF Names:

FV3-083R

Organism

Frog virus 3 (isolate Goorha) (FV-3) [Reference proteome]

Taxonomic identifier

654924 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Iridoviridae › Ranavirus › Frog virus 3

Virus host

Ambystoma (mole salamanders) [TaxID: 8295]
Hyla versicolor (chameleon treefrog) [TaxID: 30343]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana pipiens (Northern leopard frog) [TaxID: 8404]
Rana sylvatica (Wood frog) [TaxID: 45438]

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Methylates CpG residues By similarity.
Catalytic activity	S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
Sequence similarities	Belongs to the C5-methyltransferase family.

Ontologies

Keywords
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	C-5 methylation of cytosine Inferred from electronic annotation. Source: GOC chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA (cytosine-5-)-methyltransferase activity Inferred from electronic annotation. Source: EC DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Putative DNA (cytosine-5)-methyltransferase		PRO_0000410586
Sites
	Active site	62	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q67472 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C0CB3D616F36A222	FASTA	214	24,730
	10 20 30 40 50 60 MRILDLFSGT HSVPKACAQR EGWSCVTVDL ADSDYNVDVL EWDYTKDLKP REFDVVWASP 70 80 90 100 110 120 PCRYFSKLRE SNIGRGGMTK KSVKEDLETK GLPLLRRAME IIAYLQPKKF IVENPDTGRM 130 140 150 160 170 180 KEYITEWPHY VVDYCAYSDW GYRKRTRLWT DIEGFVPKTC AGKESCPNME RNPSSGRWRH 190 200 210 VLATDAGGRG RKGTTRRLRY RVPPAIIVEL LDLC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of the frog virus 3 DNA methyltransferase gene." Kaur K., Rohozinski J., Goorha R. J. Gen. Virol. 76:1937-1943(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)." Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K. Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U15575 Genomic DNA. Translation: AAA86959.1. AY548484 Genomic DNA. Translation: AAT09743.1.
RefSeq	YP_031662.1. NC_005946.1.
3D structure databases
ProteinModelPortal	Q67472.
ModBase	Search...
Protein family/group databases
REBASE	2843. M.Fvi3I.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2947802.
Phylogenomic databases
ProtClustDB	CLSP2511519.
Family and domain databases
InterPro	IPR018117. C5_DNA_meth_AS. [Graphical view]
PROSITE	PS00094. C5_MTASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNMT_FRG3G

Accession

Primary (citable) accession number: Q67472

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program