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Q67472

- DNMT_FRG3G

UniProt

Q67472 - DNMT_FRG3G

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Protein
Putative DNA (cytosine-5)-methyltransferase
Gene
FV3-083R
Organism
Frog virus 3 (isolate Goorha) (FV-3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Methylates CpG residues By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621 By similarity

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi2843. M.Fvi3IP.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative DNA (cytosine-5)-methyltransferase (EC:2.1.1.37)
Gene namesi
ORF Names:FV3-083R
OrganismiFrog virus 3 (isolate Goorha) (FV-3)
Taxonomic identifieri654924 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageIridoviridaeRanavirus
Virus hostiAmbystoma (mole salamanders) [TaxID: 8295]
Hyla versicolor (chameleon treefrog) [TaxID: 30343]
Lithobates pipiens (Northern leopard frog) (Rana pipiens) [TaxID: 8404]
Notophthalmus viridescens (Eastern newt) (Triturus viridescens) [TaxID: 8316]
Rana sylvatica (Wood frog) [TaxID: 45438]
ProteomesiUP000008770: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Putative DNA (cytosine-5)-methyltransferase
PRO_0000410586Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ67472.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q67472-1 [UniParc]FASTAAdd to Basket

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MRILDLFSGT HSVPKACAQR EGWSCVTVDL ADSDYNVDVL EWDYTKDLKP    50
REFDVVWASP PCRYFSKLRE SNIGRGGMTK KSVKEDLETK GLPLLRRAME 100
IIAYLQPKKF IVENPDTGRM KEYITEWPHY VVDYCAYSDW GYRKRTRLWT 150
DIEGFVPKTC AGKESCPNME RNPSSGRWRH VLATDAGGRG RKGTTRRLRY 200
RVPPAIIVEL LDLC 214
Length:214
Mass (Da):24,730
Last modified:November 1, 1996 - v1
Checksum:iC0CB3D616F36A222
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15575 Genomic DNA. Translation: AAA86959.1.
AY548484 Genomic DNA. Translation: AAT09743.1.
RefSeqiYP_031662.1. NC_005946.1.

Genome annotation databases

GeneIDi2947802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15575 Genomic DNA. Translation: AAA86959.1 .
AY548484 Genomic DNA. Translation: AAT09743.1 .
RefSeqi YP_031662.1. NC_005946.1.

3D structure databases

ProteinModelPortali Q67472.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 2843. M.Fvi3IP.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2947802.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the frog virus 3 DNA methyltransferase gene."
    Kaur K., Rohozinski J., Goorha R.
    J. Gen. Virol. 76:1937-1943(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae)."
    Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.
    Virology 323:70-84(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDNMT_FRG3G
AccessioniPrimary (citable) accession number: Q67472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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