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Protein

NADPH oxidase 3

Gene

Nox3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity).By similarity

Enzyme regulationi

Activated by the ototoxic drug cisplatin. Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride (By similarity).By similarity

GO - Molecular functioni

  • oxidoreductase activity Source: RGD
  • superoxide-generating NADPH oxidase activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BRENDAi1.6.3.1 5301
ReactomeiR-RNO-5668599 RHO GTPases Activate NADPH Oxidases

Protein family/group databases

PeroxiBasei5407 RnoNOx03

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH oxidase 3 (EC:1.6.3.-)
Gene namesi
Name:Nox3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303190 Nox3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 49ExtracellularSequence analysisAdd BLAST16
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 103CytoplasmicSequence analysisAdd BLAST33
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 167ExtracellularSequence analysisAdd BLAST43
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 201CytoplasmicSequence analysisAdd BLAST13
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 395ExtracellularSequence analysisAdd BLAST173
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 568CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275981 – 568NADPH oxidase 3Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ672K1
PRIDEiQ672K1

Expressioni

Tissue specificityi

Expressed in the inner ear by the spiral glanglia and the organ of Corti.1 Publication

Gene expression databases

BgeeiENSRNOG00000016490

Interactioni

Subunit structurei

Interacts with and stabilizes CYBA/p22phox.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022148

Structurei

3D structure databases

ProteinModelPortaliQ672K1
SMRiQ672K1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 284Ferric oxidoreductaseAdd BLAST230
Domaini285 – 395FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST111

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
GeneTreeiENSGT00550000074350
HOGENOMiHOG000216669
HOVERGENiHBG003760
InParanoidiQ672K1
KOiK21422
OMAiGCWILNE
OrthoDBiEOG091G09RV
PhylomeDBiQ672K1

Family and domain databases

InterProiView protein in InterPro
IPR000778 Cyt_b245_heavy_chain
IPR013112 FAD-bd_8
IPR017927 Fd_Rdtase_FAD-bd
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR029653 NOX3
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF12 PTHR11972:SF12, 1 hit
PfamiView protein in Pfam
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00466 GP91PHOX
SUPFAMiSSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

Q672K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTCWILNES VSFVVALLWL AINIYLFIDT FCWYAEEESF FYTRVILGSA
60 70 80 90 100
LAWARASAVC LNFNCMLILL PVSRNFVSLV RGTSVCCRGP WRRQLDKNLK
110 120 130 140 150
FHKLVAYGIA VNSVIHIVAH LFNLERYHLG QAKDAEGLLA ALSKLGNAPN
160 170 180 190 200
ESYLNPVRTL YTGTTTQLLM TVSGITGLVI SLALILIMTS STEFIRQSSY
210 220 230 240 250
ELFWYTHHIF IFLFISLAIH GGGRIIRGQT PESLRLHNVT FCRDHFDEWQ
260 270 280 290 300
EAASCPVPQF SGKEPSAWKW TLGPVVLYAC EIIIRFWRSH QEVVITKVVS
310 320 330 340 350
HPSAVLELHM KKRDFKMAPG QYIFIQCPSI SPLEWHPFTL TSAPQEDFFS
360 370 380 390 400
VHIRASGDWT EALLKAFGAE GQAPSELCSM PRLAVDGPFG GSLADVFHYP
410 420 430 440 450
VSVCIATGIG VTPFASLLKS VWYKCCESQS LPGLSKVYFY WICRDAAAFE
460 470 480 490 500
WFADLLLSLE TQMSEQGKAH LLSYHIYLTG WDEYQAIHIA LHWDESLDVI
510 520 530 540 550
TGLKQKTFYG RPNWNEEFKQ IAYNHPSSSI GVFFCGPKAM SKTLQKMCRL
560
YSSSDPRGVH FYYNKENF
Length:568
Mass (Da):64,416
Last modified:October 11, 2004 - v1
Checksum:i1E19B013E7320EE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY573239 mRNA Translation: AAT80343.1
RefSeqiNP_001004216.1, NM_001004216.1
UniGeneiRn.161761

Genome annotation databases

EnsembliENSRNOT00000022148; ENSRNOP00000022148; ENSRNOG00000016490
GeneIDi292279
KEGGirno:292279
UCSCiRGD:1303190 rat

Similar proteinsi

Entry informationi

Entry nameiNOX3_RAT
AccessioniPrimary (citable) accession number: Q672K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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