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Protein

NACHT, LRR and PYD domains-containing protein 9B

Gene

Nlrp9b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in inflammation.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi149 – 1568ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 9B
Alternative name(s):
NALP-delta
Gene namesi
Name:Nlrp9b
Synonyms:Nalp9, Nalp9b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2675377. Nlrp9b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10031003NACHT, LRR and PYD domains-containing protein 9BPRO_0000286336Add
BLAST

Proteomic databases

PaxDbiQ66X22.
PRIDEiQ66X22.

PTM databases

iPTMnetiQ66X22.
PhosphoSiteiQ66X22.

Expressioni

Tissue specificityi

Oocyte specific.1 Publication

Gene expression databases

BgeeiQ66X22.
CleanExiMM_NLRP9B.
ExpressionAtlasiQ66X22. differential.
GenevisibleiQ66X22. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072895.

Structurei

3D structure databases

ProteinModelPortaliQ66X22.
SMRiQ66X22. Positions 5-89, 623-981.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9191PyrinPROSITE-ProRule annotationAdd
BLAST
Domaini143 – 465323NACHTPROSITE-ProRule annotationAdd
BLAST
Repeati749 – 77022LRR 1Add
BLAST
Repeati778 – 79922LRR 2Add
BLAST
Repeati806 – 82621LRR 3Add
BLAST
Repeati835 – 85622LRR 4Add
BLAST
Repeati863 – 88321LRR 5Add
BLAST
Repeati892 – 91322LRR 6Add
BLAST
Repeati920 – 94021LRR 7Add
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ66X22.
OMAiWTYTFVF.
OrthoDBiEOG7P5T07.
PhylomeDBiQ66X22.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q66X22-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSSGYGLL KLLQKLSDEE FQRFKELLRE EPEKFKLKPI SWTKIENSSK
60 70 80 90 100
ESLVTLLNTH YPGQAWNMML SLFLQVNRED LSIMAQKKKR HKQTKYKKFM
110 120 130 140 150
KTTFERIWTL ETNTHIPDRN YHLIVEVQYK ALQEIFDSES EPVTAIVAGT
160 170 180 190 200
TGEGKTTFLR KAMLDWASGV LLQNRFQYVF FFSVFSLNNT TELSLAELIS
210 220 230 240 250
STLPESSETV DDILSDPKRI LFILDGFDYL KFDLELRTNL CNDWRKRLPT
260 270 280 290 300
QIVLSSLLQK IMLPGCSLLL ELGQISVPKI RHLLKYPRVI TMQGFSERSV
310 320 330 340 350
EFYCMSFFDN QRGIEVAENL RNNEVLHLCS NPYLCWMFCS CLKWQFDREE
360 370 380 390 400
EGYFKAKTDA AFFTNFMVSA FKSTYAHSPS KQNRARLKTL CTLAVEGMWK
410 420 430 440 450
ELFVFDSEDL RRNGISESDK AVWLKMQFLQ THGNHTVFYH PTLQSYFAAM
460 470 480 490 500
FYFLKQDKDI CVPVIGSIPQ LLGNMYARGQ TQWLQLGTFL FGLINEQVAA
510 520 530 540 550
LLQPCFGFIQ PIYVRQEIIC YFKCLGQQEC NEKLERSQTL FSCLRDSQEE
560 570 580 590 600
RFVRQVVDLL EEITVDISSS DVLSVTAYAL QKSSKLKKLH LHIQKTVFSE
610 620 630 640 650
IYCPDHCKTR TSIGKRRNTA EYWKTLCGIF CNLYVLDLDS CQFNKRAIQD
660 670 680 690 700
LCNSMSPTPT VPLTAFKLQS LSCSFMADFG DGSLFHTLLQ LPHLKYLNLY
710 720 730 740 750
GTYLSMDVTE KLCAALRCSA CRVEELLLGK CGISSKACGI IAISLINSKV
760 770 780 790 800
KHLSLVENPL KNKGVMSLCE MLKDPSCVLQ SLMLSYCCLT FIACGHLYEA
810 820 830 840 850
LLSNKHLSLL DLGSNFLEDT GVNLLCEALK DPNCTLKELW LPGCFLTSQC
860 870 880 890 900
CEEISAVLIC NRNLKTLKLG NNNIQDTGVR QLCEALSHPN CNLECLGLDL
910 920 930 940 950
CEFTSDCCKD LALALTTCKT LNSLNLDWKT LDHSGLVVLC EALNHKRCNL
960 970 980 990 1000
KMLGLDKSAF SEESQTLLQD VEKKNNNLNI LHHPWFEAER NKRGTRLVWN

SRN
Length:1,003
Mass (Da):114,802
Last modified:October 11, 2004 - v1
Checksum:iCDC853C75A26EC91
GO
Isoform 2 (identifier: Q66X22-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-617: Missing.
     842-898: Missing.
     955-1003: LDKSAFSEES...GTRLVWNSRN → SGELMFLMKW...FYGERLTWHS

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):56,766
Checksum:i298748FDAD7C7640
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei178 – 617440Missing in isoform 2. 1 PublicationVSP_025024Add
BLAST
Alternative sequencei842 – 89857Missing in isoform 2. 1 PublicationVSP_025025Add
BLAST
Alternative sequencei955 – 100349LDKSA…WNSRN → SGELMFLMKWKDSDEADLVQ AKEANMICPQIVISFYGERL TWHS in isoform 2. 1 PublicationVSP_025026Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596196 mRNA. Translation: AAU06317.1.
AY360471 mRNA. Translation: AAQ64009.1.
CCDSiCCDS20920.1. [Q66X22-1]
RefSeqiNP_918947.2. NM_194058.2. [Q66X22-1]
XP_006540001.1. XM_006539938.2. [Q66X22-1]
XP_006540002.1. XM_006539939.2. [Q66X22-1]
UniGeneiMm.277114.

Genome annotation databases

EnsembliENSMUST00000073151; ENSMUSP00000072895; ENSMUSG00000060508. [Q66X22-1]
ENSMUST00000117909; ENSMUSP00000113762; ENSMUSG00000060508. [Q66X22-2]
GeneIDi243874.
KEGGimmu:243874.
UCSCiuc009fnt.1. mouse. [Q66X22-1]
uc012fbm.1. mouse. [Q66X22-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596196 mRNA. Translation: AAU06317.1.
AY360471 mRNA. Translation: AAQ64009.1.
CCDSiCCDS20920.1. [Q66X22-1]
RefSeqiNP_918947.2. NM_194058.2. [Q66X22-1]
XP_006540001.1. XM_006539938.2. [Q66X22-1]
XP_006540002.1. XM_006539939.2. [Q66X22-1]
UniGeneiMm.277114.

3D structure databases

ProteinModelPortaliQ66X22.
SMRiQ66X22. Positions 5-89, 623-981.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072895.

PTM databases

iPTMnetiQ66X22.
PhosphoSiteiQ66X22.

Proteomic databases

PaxDbiQ66X22.
PRIDEiQ66X22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073151; ENSMUSP00000072895; ENSMUSG00000060508. [Q66X22-1]
ENSMUST00000117909; ENSMUSP00000113762; ENSMUSG00000060508. [Q66X22-2]
GeneIDi243874.
KEGGimmu:243874.
UCSCiuc009fnt.1. mouse. [Q66X22-1]
uc012fbm.1. mouse. [Q66X22-2]

Organism-specific databases

CTDi243874.
MGIiMGI:2675377. Nlrp9b.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129675.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ66X22.
OMAiWTYTFVF.
OrthoDBiEOG7P5T07.
PhylomeDBiQ66X22.

Miscellaneous databases

NextBioi385990.
PROiQ66X22.
SOURCEiSearch...

Gene expression databases

BgeeiQ66X22.
CleanExiMM_NLRP9B.
ExpressionAtlasiQ66X22. differential.
GenevisibleiQ66X22. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Murine NALPs: a family of proteins involved in inflammation."
    Martinon F., Hofmann K., Tschopp J.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6J.

Entry informationi

Entry nameiNAL9B_MOUSE
AccessioniPrimary (citable) accession number: Q66X22
Secondary accession number(s): Q6UTW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2004
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.