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Protein

NACHT, LRR and PYD domains-containing protein 4E

Gene

Nlrp4e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi154 – 161ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Inflammatory response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-3134975. Regulation of innate immune responses to cytosolic DNA.
R-MMU-3270619. IRF3-mediated induction of type I IFN.

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 4E
Alternative name(s):
NALP-epsilon
Gene namesi
Name:Nlrp4e
Synonyms:Nalp4e, Nlrp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3056600. Nlrp4e.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002863321 – 978NACHT, LRR and PYD domains-containing protein 4EAdd BLAST978

Proteomic databases

MaxQBiQ66X19.
PaxDbiQ66X19.
PRIDEiQ66X19.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045693.
CleanExiMM_NLRP4E.
GenevisibleiQ66X19. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075794.

Structurei

3D structure databases

ProteinModelPortaliQ66X19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 93PyrinPROSITE-ProRule annotationAdd BLAST93
Domaini148 – 471NACHTPROSITE-ProRule annotationAdd BLAST324
Repeati594 – 617LRR 1Add BLAST24
Repeati694 – 717LRR 2Add BLAST24
Repeati746 – 773LRR 3Add BLAST28
Repeati802 – 825LRR 4Add BLAST24
Repeati859 – 882LRR 5Add BLAST24
Repeati916 – 940LRR 6Add BLAST25

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133669.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ66X19.
OMAiLNRNTHE.
OrthoDBiEOG091G01CG.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
PS51450. LRR. 4 hits.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66X19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFFSDFGL MWYLEELNKK EFMKFKELLQ QEILQLGLKH ISWTEVKKAS
60 70 80 90 100
REDLANLLLK HYEEKKAWDM TFKIFQKMNR QDLMERAGRE IAGHSKLYQV
110 120 130 140 150
HLKKKLTHDY ARKFNIKDQD SLKQKFTQDD CDHFENLLIS KATGKKPHMV
160 170 180 190 200
FLQGVAGIGK SLMLTKLMLA WSEGMVFQNK FSYIFYFCCQ DVKKMKRASL
210 220 230 240 250
AELISKEWPN ASAPIEEILS QPEKLLFVID NLEVMECDMS EWESELCDDC
260 270 280 290 300
MEKQPVNILM SSLLRRKMLP ESSFLVSATP ETFEKIEDRI ECTNVKMMAG
310 320 330 340 350
FNESSIKVYF YSLFQDRNRT QEIFSLVREN EQLFSVCQVP VLCWMVATCL
360 370 380 390 400
KKEIEKGRDP VSICRRITSL YTTYIFNLFI PHSAQYPSKK SQDQLQGLCS
410 420 430 440 450
LAAEGMWTDT FVFAEEALRR NGIMDSDIST LLDVRILEKS KESEKSYIFL
460 470 480 490 500
HPSIQEVCAA IFHLLKSHVD HPSQDVKSIE ALIFTFLKKV KIQWIFFGSF
510 520 530 540 550
IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNK ELQEQIDGMK
560 570 580 590 600
LFYCLFEMDD EAFLPQVMNC MEQIKFVAKD YSDVIVAAHC LQHCSTLKKL
610 620 630 640 650
SLSTQNILSE GQEHSYTEKL LICWHHVCSV LTSSKDIHVL QVKDTNFNER
660 670 680 690 700
AFLVLYSHLK YPSCILKVLE VNNVTLLCDN RLLFELIQNQ RLQLLNLSLT
710 720 730 740 750
FLSHNDVKLL CDVLNQAECN IEKLMVADCN LSPDDCKVFV SVLISSKMLK
760 770 780 790 800
HLNLSSNNLD KGISSLSKAL CHPDCVLKNL VLAKCSLSEE CWHYLSEVLR
810 820 830 840 850
RNKTLTHLDI SFNDLKDEGL KVLCGALTLP DSVLISLSVR YCLITTSGCQ
860 870 880 890 900
DLAEVLRNNQ NLRNLQISNN KIEDAGVKLL CDAIKHPNCH LENIGLEACA
910 920 930 940 950
LTGACCEDLA SSFTHCKTLL GINLQENALD HSGLVALFEA MKQQQCTVNL
960 970
RGLRITDFDK ETQEFLMAEK EKNPYLSI
Length:978
Mass (Da):112,473
Last modified:July 27, 2011 - v2
Checksum:i24A25AFF43FFE933
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135E → G in AAU06318 (PubMed:15317747).Curated1
Sequence conflicti590C → S in AAU06318 (PubMed:15317747).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596197 mRNA. Translation: AAU06318.1.
AC150900 Genomic DNA. No translation available.
CCDSiCCDS20928.1.
RefSeqiNP_001004194.2. NM_001004194.2.
UniGeneiMm.442342.

Genome annotation databases

EnsembliENSMUST00000076470; ENSMUSP00000075794; ENSMUSG00000045693.
GeneIDi446099.
KEGGimmu:446099.
UCSCiuc009fod.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596197 mRNA. Translation: AAU06318.1.
AC150900 Genomic DNA. No translation available.
CCDSiCCDS20928.1.
RefSeqiNP_001004194.2. NM_001004194.2.
UniGeneiMm.442342.

3D structure databases

ProteinModelPortaliQ66X19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075794.

Proteomic databases

MaxQBiQ66X19.
PaxDbiQ66X19.
PRIDEiQ66X19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076470; ENSMUSP00000075794; ENSMUSG00000045693.
GeneIDi446099.
KEGGimmu:446099.
UCSCiuc009fod.2. mouse.

Organism-specific databases

CTDi446099.
MGIiMGI:3056600. Nlrp4e.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00860000133669.
HOGENOMiHOG000294064.
HOVERGENiHBG063656.
InParanoidiQ66X19.
OMAiLNRNTHE.
OrthoDBiEOG091G01CG.

Enzyme and pathway databases

ReactomeiR-MMU-3134975. Regulation of innate immune responses to cytosolic DNA.
R-MMU-3270619. IRF3-mediated induction of type I IFN.

Miscellaneous databases

PROiQ66X19.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045693.
CleanExiMM_NLRP4E.
GenevisibleiQ66X19. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
PS51450. LRR. 4 hits.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAL4E_MOUSE
AccessioniPrimary (citable) accession number: Q66X19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.