Q66T64 (PHOSP_RABVB) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 9, 2013.
Version 29.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphoprotein Short name=Protein P Alternative name(s): Protein M1 | ||
| Gene names |
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| Organism | Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV) [Complete proteome] | ||
| Taxonomic identifier | 445793 [NCBI] | ||
| Taxonomic lineage | Viruses › ssRNA negative-strand viruses › Mononegavirales › Rhabdoviridae › Lyssavirus ›  | ||
| Virus host | Homo sapiens (Human) [TaxID: 9606] Mammalia [TaxID: 40674] |
Protein attributes
| Sequence length | 297 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body By similarity. |
| Subunit structure | Homotrimer when phosphorylated. This trimer is stabilized by binding to the L protein. Binds soluble protein N, and ribonucleocapsid. Interacts with host DYNLL1 and DYNLL2; this interaction may play a role in intracellular microtubule-dependent virus transport of incoming virus. Interacts with host STAT1, STAT2 and PML. Isoform P3 binds host PML By similarity. |
| Subcellular location | Phosphoprotein: Virion. Host cytoplasm By similarity. Isoform P2: Host cytoplasm By similarity. Isoform P3: Host nucleus By similarity. Isoform P5: Host nucleus By similarity. |
| Post-translational modification | Phosphorylated by host PKC and by an unknown kinase By similarity. |
| Sequence similarities | Belongs to the lyssavirus protein P family. |
Ontologies
Alternative products
| This entry describes 4 isoforms produced by alternative initiation. [Align] [Select] | ||||||
| Isoform P (identifier: Q66T64-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform P2 (identifier: Q66T64-2) The sequence of this isoform differs from the canonical sequence as follows: 1-19: Missing. | ||||||
| Isoform P3 (identifier: Q66T64-3) The sequence of this isoform differs from the canonical sequence as follows: 1-52: Missing. | ||||||
| Isoform P5 (identifier: Q66T64-4) The sequence of this isoform differs from the canonical sequence as follows: 1-82: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 297 | 297 | Phosphoprotein | PRO_0000295250 | |||||
Regions | |||||||||
| Region | 138 – 172 | 35 | DYNLL1 and DYNLL2 binding By similarity | ||||||
| Motif | 49 – 58 | 10 | Nuclear export signal By similarity | ||||||
| Motif | 211 – 214 | 4 | Nuclear localization signal By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 64 | 1 | Phosphoserine; by host By similarity | ||||||
| Modified residue | 162 | 1 | Phosphoserine; by host PKC By similarity | ||||||
| Modified residue | 210 | 1 | Phosphoserine; by host PKC By similarity | ||||||
| Modified residue | 271 | 1 | Phosphoserine; by host PKC By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 82 | 82 | Missing in isoform P5. | VSP_026898 | |||||
| Alternative sequence | 1 – 52 | 52 | Missing in isoform P3. | VSP_026899 | |||||
| Alternative sequence | 1 – 19 | 19 | Missing in isoform P2. | VSP_026900 | |||||
Sequences
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References
| [1] | "Identification of viral genomic elements responsible for rabies virus neuroinvasiveness." Faber M., Pulmanausahakul R., Nagao K., Prosniak M., Rice A.B., Koprowski H., Schnell M.J., Dietzschold B. Proc. Natl. Acad. Sci. U.S.A. 101:16328-16332(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY705373 Genomic RNA. Translation: AAU11516.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1VYI based on UniProtKB P22363. |
| ProteinModelPortal | Q66T64. |
| SMR | Q66T64. Positions 186-294. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR004259. PP_M1. [Graphical view] |
| Pfam | PF03012. PP_M1. 1 hit. [Graphical view] |
| ProDom | PD004155. PP_M1. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | PHOSP_RABVB | ||||||||
| Accession | Primary (citable) accession number: Q66T64 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |