Reviewed,
UniProtKB/Swiss-Prot Q66T60 (L_RABVB)
Last modified
November 4, 2008.
Version 18.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Large structural protein Short name=Protein L Alternative name(s): Transcriptase Replicase Including the following 3 domains: 1- Recommended name: RNA-directed RNA polymerase EC=2.7.7.48 2- Recommended name: mRNA (guanine-N(7)-)-methyltransferase EC=2.1.1.56 3- Recommended name: mRNA guanylyltransferase EC=2.7.7.- | ||
| Gene names |
| ||
| Organism | Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV) [Complete proteome] | ||
| Taxonomic identifier | 445793 [NCBI] | ||
| Taxonomic lineage | Viruses › ssRNA negative-strand viruses › Mononegavirales › Rhabdoviridae › Lyssavirus | ||
| Virus host | Mammalia [TaxID: 40674] |
Protein attributes
| Sequence length | 2128 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-7-N-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently five subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals By similarity. |
| Catalytic activity | Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA. |
| Subunit structure | Interacts with the P protein to form the functional polymerase By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the rhabdoviruses protein L family. Contains 1 RdRp catalytic domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | RNA replication mRNA capping mRNA processing |
| Cellular component | Cytoplasm Virion |
| Ligand | ATP-binding Nucleotide-binding S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Nucleotidyltransferase RNA-directed RNA polymerase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
Gene Ontology (GO) | |
| Biological process | mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW transcription, RNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW virionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 2128 | 2128 | Large structural protein | PRO_0000294418 | |||||
Regions | |||||||||
| Domain | 612 – 800 | 189 | RdRp catalytic | ||||||
| Region | 1563 – 2128 | 566 | Interaction with P protein By similarity | ||||||
Sequences
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References
| [1] | "Identification of viral genomic elements responsible for rabies virus neuroinvasiveness." Faber M., Pulmanausahakul R., Nagao K., Prosniak M., Rice A.B., Koprowski H., Schnell M.J., Dietzschold B. Proc. Natl. Acad. Sci. U.S.A. 101:16328-16332(2004) [PubMed: 15520387] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. |
Cross-references
Sequence databases | |
|---|---|
| AY705373 Genomic RNA. Translation: AAU11519.1. | |
3D structure databases | |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR017234. RNA-dir_RNA_pol_rhabdovir. IPR014023. RNA_pol_cat. IPR001016. RNA_pol_L_viral. [Graphical view] |
| Pfam | PF00946. Paramyx_RNA_pol. 1 hit. [Graphical view] |
| PIRSF | PIRSF037546. RNA_pol_RhabdoV_sub. 1 hit. |
| PROSITE | PS50526. RDRP_SSRNA_NEG_NONSEG. 1 hit. [Graphical view] |
| BLOCKS | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | L_RABVB | ||||||||
| Accession | Primary (citable) accession number: Q66T60 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||

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