Reviewed, UniProtKB/Swiss-Prot Q66T47 (AVR2B_PIG)

Names and origin

Protein names

Recommended name:
    Activin receptor type-2B
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IIB
      Short name=ACTR-IIB

Gene names

Name:

ACVR2B

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A By similarity.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	activin receptor signaling pathway Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin receptor activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 512	494	Activin receptor type-2B		PRO_0000234419
Regions
	Topological domain	19 – 137	119	Extracellular Potential
	Transmembrane	138 – 158	21	Potential
	Topological domain	159 – 512	354	Cytoplasmic Potential
	Domain	190 – 480	291	Protein kinase
	Nucleotide binding	196 – 204	9	ATP By similarity
Sites
	Active site	321	1	Proton acceptor By similarity
	Binding site	217	1	ATP By similarity
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
	Disulfide bond	29 ↔ 59		By similarity
	Disulfide bond	49 ↔ 77		By similarity
	Disulfide bond	84 ↔ 103		By similarity
	Disulfide bond	90 ↔ 102		By similarity
	Disulfide bond	104 ↔ 109		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q66T47-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 59A5A00239A92EAC	FASTA	512	57,693
	10 20 30 40 50 60 MTAPWAALAL LWGSLCVGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 70 80 90 100 110 120 ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 130 140 150 160 170 180 GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP 190 200 210 220 230 240 PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 250 260 270 280 290 300 HENLLQFIAA EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 310 320 330 340 350 360 LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 370 380 390 400 410 420 TRRYMAPEVL EGAINFQRNA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 430 440 450 460 470 480 HPSLEELQEV VVHKKMRPAI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 490 500 510 IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI

References

[1]	"Complete sequence of activin receptor IIB cDNA in boars." Song J.H., Wise T.H., Ford J.J. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY705387 mRNA. Translation: AAU07920.1.
RefSeq	NP_001005350.1.
UniGene	Ssc.42773
3D structure databases
SMR	Q66T47. Positions 24-117, 190-484.
ModBase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000012324; ENSSSCP00000012002; ENSSSCG00000011257; Sus scrofa. [Genome view]
GeneID	448845.
KEGG	ssc:448845.
Organism-specific databases
CTD	448845.
Phylogenomic databases
HOVERGEN	Q66T47.
Enzyme and pathway databases
BRENDA	2.7.11.30. 249.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR015768. Activin_II_recpt_C. IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. [Graphical view]
PANTHER	PTHR23255:SF10. Activin_II_recpt_C. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AVR2B_PIG

Accession

Primary (citable) accession number: Q66T47

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	October 11, 2004
Last modified:	January 19, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)