Q66SS1 (Q66SS1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Paired box gene 6 isoform a EMBL AAU12168.1
Organism	Homo sapiens (Human) EMBL AAU12168.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity RuleBase RU000491.
Sequence similarities	Contains 1 paired domain. RuleBase RU000491

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU000491
Cellular component	Nucleus RuleBase RU000491
Domain	Homeobox RuleBase RU000682 Paired box RuleBase RU000491
Ligand	DNA-binding RuleBase RU000491
Molecular function	Developmental protein RuleBase RU000491
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q66SS1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: C33CDD2C1B13C397	FASTA	422	46,683
	10 20 30 40 50 60 MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN GCVSKILGRY 70 80 90 100 110 120 YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW EIRDRLLSEG VCTNDNIPSV 130 140 150 160 170 180 SSINRVLRNL ASEKQQMGAD GMYDKLRMLN GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ 190 200 210 220 230 240 EGGGENTNSI SSNGEDSDEA QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR 250 260 270 280 290 300 ERLAAKIDLP EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP 310 320 330 340 350 360 QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ TSSYSCMLPT 370 380 390 400 410 420 SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG TTSTGLISPG VSVPVQVPGS EPDMSQYWPR LQ

References

[1]	Perez-Pinera P., Bray T.L., Vega J.A., Deuel T.F. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY707088 mRNA. Translation: AAU12168.1.
IPI	IPI00218800.
RefSeq	NP_000271.1. NM_000280.4. NP_001121084.1. NM_001127612.1. NP_001245393.1. NM_001258464.1. NP_001245394.1. NM_001258465.1.
UniGene	Hs.270303. Hs.611376.
3D structure databases
ProteinModelPortal	Q66SS1.
ModBase	Search...
Proteomic databases
PRIDE	Q66SS1.
Protocols and materials databases
DNASU	5080.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5080.
KEGG	hsa:5080.
Organism-specific databases
CTD	5080.
PharmGKB	PA32960.
Phylogenomic databases
HOVERGEN	HBG009115.
KO	K08031.
Gene expression databases
ArrayExpress	Q66SS1.
Family and domain databases
Gene3D	1.10.10.10. 2 hits. 1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR001523. Paired_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF00292. PAX. 1 hit. [Graphical view]
PRINTS	PR00027. PAIREDBOX.
SMART	SM00389. HOX. 1 hit. SM00351. PAX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 2 hits.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00034. PAIRED_1. 1 hit. PS51057. PAIRED_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5080.
NextBio	19596.

Entry information

Entry name

Q66SS1_HUMAN

Accession

Primary (citable) accession number: Q66SS1

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 29, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.