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Protein
Submitted name:

6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 isoform 1

Gene

PFKFB4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseImported, KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 isoform 1Imported (EC:2.7.1.105Imported, EC:3.1.3.46Imported)
Submitted name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4Imported
Gene namesi
Name:PFKFB4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114268.11
HGNCiHGNC:8875 PFKFB4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114268

Expressioni

Gene expression databases

BgeeiENSG00000114268

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 2496PF2KInterPro annotationAdd BLAST215

Phylogenomic databases

eggNOGiKOG0234 Eukaryota
COG0406 LUCA
GeneTreeiENSGT00390000018751
HOGENOMiHOG000181112
HOVERGENiHBG005628

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR003094 6Pfruct_kin
IPR013079 6Phosfructo_kin
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR027417 P-loop_NTPase
IPR001345 PG/BPGM_mutase_AS
PANTHERiPTHR10606 PTHR10606, 1 hit
PfamiView protein in Pfam
PF01591 6PF2K, 1 hit
PF00300 His_Phos_1, 1 hit
PRINTSiPR00991 6PFRUCTKNASE
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q66S35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRELTQN PLKKIWMPYS NGRPALHACQ RGVCMTNCPT LIVMVGLPAR
60 70 80 90 100
GKTYISKKLT RYLNWIGVPT REFNVGQYRR DVVKTYKSFE FFLPDNEEGL
110 120 130 140 150
KIRKQCALAA LRDVRRFLSE EGGHVAVFDA TNTTRERRAT IFNFGEQNGY
160 170 180 190 200
KTFFVESICV DPEVIAANIV QVKLGSPDYV NRDSDEATED FMRRIECYEN
210 220 230 240 250
SYESLDEDLD RDLSYIKIMD VGQSYVVNRV ADHIQSRIVY YLMNIHVTPR
260 270 280 290 300
SIYLCRHGES ELNLKGRIGG DPGLSPRGRE FAKSLAQFIS DQNIKDLKVW
310 320 330 340 350
TSQMKRTIQT AEALGVPYEQ WKGVCEEMTY EEIQDNYPLE FALRDQDKYR
360 370 380 390 400
YRYPKGESYE DLVQRLEPVI MELERQENVL VICHQAVMRC LLAYFLDKAA
410 420 430 440 450
EQLPYLKCPL HTVLKLTPVA YGCKVESIFL NVAAVNTHRD RPQNVDISRP
460
PEEALVTVPA HQ
Length:462
Mass (Da):53,285
Last modified:October 11, 2004 - v1
Checksum:i28F3B97F9C8911F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134772 Genomic DNA No translation available.
AY707863 mRNA Translation: AAU11326.1
RefSeqiNP_001304064.1, NM_001317135.1
UniGeneiHs.476217

Genome annotation databases

EnsembliENST00000416568; ENSP00000388394; ENSG00000114268
GeneIDi5210
UCSCiuc010hkb.4 human

Similar proteinsi

Entry informationi

Entry nameiQ66S35_HUMAN
AccessioniPrimary (citable) accession number: Q66S35
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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