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Q66PJ3

- AR6P4_HUMAN

UniProt

Q66PJ3 - AR6P4_HUMAN

Protein

ADP-ribosylation factor-like protein 6-interacting protein 4

Gene

ARL6IP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (09 Jul 2014)
      Previous versions | rss
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    Functioni

    Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA splicing Source: ProtInc

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor-like protein 6-interacting protein 4
    Short name:
    ARL-6-interacting protein 4
    Short name:
    Aip-4
    Alternative name(s):
    HSP-975
    HSVI-binding protein
    SR-15
    SRp25
    Short name:
    SR-25
    Splicing factor SRrp37
    Gene namesi
    Name:ARL6IP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:18076. ARL6IP4.

    Subcellular locationi

    Nucleusnucleolus 1 Publication. Nucleus speckle 1 Publication

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell
    3. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134879338.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421ADP-ribosylation factor-like protein 6-interacting protein 4PRO_0000312270Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei332 – 3321Phosphoserine7 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ66PJ3.
    PaxDbiQ66PJ3.
    PRIDEiQ66PJ3.

    PTM databases

    PhosphoSiteiQ66PJ3.

    Expressioni

    Tissue specificityi

    Isoforms 3 and 7 were identified in brain, pancreas, prostate, and testis, but little or no message could be detected in other tissues.1 Publication

    Developmental stagei

    Expressed only in G1/S phase.1 Publication

    Inductioni

    In case of Herpes simplex virus (HSVI)-binding to cells.1 Publication

    Gene expression databases

    BgeeiQ66PJ3.
    CleanExiHS_ARL6IP4.
    GenevestigatoriQ66PJ3.

    Organism-specific databases

    HPAiHPA052098.

    Interactioni

    Subunit structurei

    Interacts with ARL6 By similarity. Interacts with ZCCHC17. Interacts with SRSF2.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IKBKGQ9Y6K92EBI-2683099,EBI-81279

    Protein-protein interaction databases

    BioGridi119477. 8 interactions.
    IntActiQ66PJ3. 7 interactions.
    MINTiMINT-5010073.
    STRINGi9606.ENSP00000313422.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66PJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi190 – 28293Ser-richAdd
    BLAST
    Compositional biasi286 – 31227Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ARL6IP4 family.Curated

    Phylogenomic databases

    eggNOGiNOG83556.
    HOVERGENiHBG102109.
    OMAiWHRSAEE.
    PhylomeDBiQ66PJ3.
    TreeFamiTF350468.

    Family and domain databases

    InterProiIPR019532. Nucl_RNA-splicing_assoc_SR-25.
    [Graphical view]
    PfamiPF10500. SR-25. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q66PJ3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK    50
    TRAPQSGARS RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV 100
    GAASADTGVR GCGARGPAPL LASAGGGRAR DGTWGVRTKG SGAALPSRPA 150
    SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR ARGAMAHVGS RKRSRSRSRS 200
    RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP SPCITERSKQ 250
    KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK 300
    KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI 350
    QAMKPMTKEE WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE 400
    INKQATRGDC LAFQMRAGLL P 421
    Length:421
    Mass (Da):44,915
    Last modified:July 9, 2014 - v2
    Checksum:i46C75D66A5181DAC
    GO
    Isoform 2 (identifier: Q66PJ3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         238-245: Missing.

    Show »
    Length:413
    Mass (Da):44,159
    Checksum:iBC723AA29C3D5E59
    GO
    Isoform 3 (identifier: Q66PJ3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         227-245: Missing.

    Show »
    Length:402
    Mass (Da):43,132
    Checksum:i13B57EF2169FA844
    GO
    Isoform 4 (identifier: Q66PJ3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         227-245: Missing.
         404-421: QATRGDCLAFQMRAGLLP → VGVAPLPAIRPQLCL

    Show »
    Length:399
    Mass (Da):42,731
    Checksum:i23D0D604986EE066
    GO
    Isoform 5 (identifier: Q66PJ3-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         238-245: Missing.
         317-364: Missing.

    Show »
    Length:365
    Mass (Da):38,699
    Checksum:i7E2C81AE496AC2D2
    GO
    Isoform 6 (identifier: Q66PJ3-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         238-276: ASPSPCITER...SSSSSSSSSS → VLLAPLLPPR...GGRRRRRGRS
         277-421: Missing.

    Show »
    Length:276
    Mass (Da):28,528
    Checksum:i6F944F7B299C9953
    GO
    Isoform 7 (identifier: Q66PJ3-7) [UniParc]FASTAAdd to Basket

    Also known as: SRrp37-2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-184: Missing.
         227-237: Missing.

    Show »
    Length:226
    Mass (Da):25,349
    Checksum:iC41994822C524656
    GO

    Sequence cautioni

    Isoform 6 : The sequence AAF76892.1 differs from that shown. Reason: Frameshift at position 276.
    The sequence AAF76892.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH01958.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH15569.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH15909.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH94839.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence ACF07995.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA94744.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601S → P in AAH94839. (PubMed:15489334)Curated
    Sequence conflicti233 – 2331A → V in AAF76892. (PubMed:11884129)Curated

    RNA editingi

    Partially edited. In the brain, edited at about 68%.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti149 – 1491P → A.
    Corresponds to variant rs12825243 [ dbSNP | Ensembl ].
    VAR_059583
    Natural varianti286 – 2861K → R in RNA edited version.
    Corresponds to variant rs3178165 [ dbSNP | Ensembl ].
    VAR_058333

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 184184Missing in isoform 7. 1 PublicationVSP_054581Add
    BLAST
    Alternative sequencei227 – 24519Missing in isoform 3 and isoform 4. 3 PublicationsVSP_029780Add
    BLAST
    Alternative sequencei227 – 23711Missing in isoform 7. 1 PublicationVSP_054582Add
    BLAST
    Alternative sequencei238 – 27639ASPSP…SSSSS → VLLAPLLPPRPPPLPPVMAG RSGGSTRTRGGRRRRRGRS in isoform 6. 1 PublicationVSP_029781Add
    BLAST
    Alternative sequencei238 – 2458Missing in isoform 2 and isoform 5. 3 PublicationsVSP_029782
    Alternative sequencei277 – 421145Missing in isoform 6. 1 PublicationVSP_029783Add
    BLAST
    Alternative sequencei317 – 36448Missing in isoform 5. 1 PublicationVSP_029784Add
    BLAST
    Alternative sequencei404 – 42118QATRG…AGLLP → VGVAPLPAIRPQLCL in isoform 4. 1 PublicationVSP_029785Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU624490 mRNA. Translation: ACF07995.1. Different initiation.
    EU624491 mRNA. Translation: ACF07996.1.
    AC026362 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW98376.1.
    CH471054 Genomic DNA. Translation: EAW98374.1.
    BC001958 mRNA. Translation: AAH01958.1. Different initiation.
    BC015569 mRNA. Translation: AAH15569.1. Different initiation.
    BC015909 mRNA. Translation: AAH15909.2. Different initiation.
    BC094839 mRNA. Translation: AAH94839.1. Different initiation.
    AF267748 mRNA. Translation: AAF76892.1. Sequence problems.
    AB035384 mRNA. Translation: BAA94744.1. Different initiation.
    DQ099385 mRNA. Translation: AAZ13761.1.
    EF036485 mRNA. Translation: ABO65071.1.
    CCDSiCCDS31923.1. [Q66PJ3-1]
    CCDS41856.1. [Q66PJ3-4]
    CCDS45004.1. [Q66PJ3-2]
    CCDS53843.1. [Q66PJ3-3]
    CCDS61273.1. [Q66PJ3-7]
    PIRiJC7220.
    RefSeqiNP_001002251.2. NM_001002251.2.
    NP_001002252.2. NM_001002252.2.
    NP_001265307.1. NM_001278378.1.
    NP_001265308.1. NM_001278379.1.
    NP_001265309.1. NM_001278380.1. [Q66PJ3-7]
    NP_057722.3. NM_016638.3.
    NP_061164.3. NM_018694.3.
    UniGeneiHs.103561.

    Genome annotation databases

    EnsembliENST00000315580; ENSP00000313422; ENSG00000182196. [Q66PJ3-1]
    ENST00000357866; ENSP00000350532; ENSG00000182196.
    ENST00000426960; ENSP00000406036; ENSG00000182196.
    ENST00000454885; ENSP00000396723; ENSG00000182196. [Q66PJ3-7]
    ENST00000543566; ENSP00000442718; ENSG00000182196. [Q66PJ3-3]
    GeneIDi51329.
    KEGGihsa:51329.
    UCSCiuc001uec.3. human. [Q66PJ3-2]
    uc001ued.3. human. [Q66PJ3-1]
    uc001uef.3. human. [Q66PJ3-4]
    uc001uei.3. human. [Q66PJ3-5]

    Polymorphism databases

    DMDMi74736329.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism, RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU624490 mRNA. Translation: ACF07995.1 . Different initiation.
    EU624491 mRNA. Translation: ACF07996.1 .
    AC026362 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW98376.1 .
    CH471054 Genomic DNA. Translation: EAW98374.1 .
    BC001958 mRNA. Translation: AAH01958.1 . Different initiation.
    BC015569 mRNA. Translation: AAH15569.1 . Different initiation.
    BC015909 mRNA. Translation: AAH15909.2 . Different initiation.
    BC094839 mRNA. Translation: AAH94839.1 . Different initiation.
    AF267748 mRNA. Translation: AAF76892.1 . Sequence problems.
    AB035384 mRNA. Translation: BAA94744.1 . Different initiation.
    DQ099385 mRNA. Translation: AAZ13761.1 .
    EF036485 mRNA. Translation: ABO65071.1 .
    CCDSi CCDS31923.1. [Q66PJ3-1 ]
    CCDS41856.1. [Q66PJ3-4 ]
    CCDS45004.1. [Q66PJ3-2 ]
    CCDS53843.1. [Q66PJ3-3 ]
    CCDS61273.1. [Q66PJ3-7 ]
    PIRi JC7220.
    RefSeqi NP_001002251.2. NM_001002251.2.
    NP_001002252.2. NM_001002252.2.
    NP_001265307.1. NM_001278378.1.
    NP_001265308.1. NM_001278379.1.
    NP_001265309.1. NM_001278380.1. [Q66PJ3-7 ]
    NP_057722.3. NM_016638.3.
    NP_061164.3. NM_018694.3.
    UniGenei Hs.103561.

    3D structure databases

    ProteinModelPortali Q66PJ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119477. 8 interactions.
    IntActi Q66PJ3. 7 interactions.
    MINTi MINT-5010073.
    STRINGi 9606.ENSP00000313422.

    PTM databases

    PhosphoSitei Q66PJ3.

    Polymorphism databases

    DMDMi 74736329.

    Proteomic databases

    MaxQBi Q66PJ3.
    PaxDbi Q66PJ3.
    PRIDEi Q66PJ3.

    Protocols and materials databases

    DNASUi 51329.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315580 ; ENSP00000313422 ; ENSG00000182196 . [Q66PJ3-1 ]
    ENST00000357866 ; ENSP00000350532 ; ENSG00000182196 .
    ENST00000426960 ; ENSP00000406036 ; ENSG00000182196 .
    ENST00000454885 ; ENSP00000396723 ; ENSG00000182196 . [Q66PJ3-7 ]
    ENST00000543566 ; ENSP00000442718 ; ENSG00000182196 . [Q66PJ3-3 ]
    GeneIDi 51329.
    KEGGi hsa:51329.
    UCSCi uc001uec.3. human. [Q66PJ3-2 ]
    uc001ued.3. human. [Q66PJ3-1 ]
    uc001uef.3. human. [Q66PJ3-4 ]
    uc001uei.3. human. [Q66PJ3-5 ]

    Organism-specific databases

    CTDi 51329.
    GeneCardsi GC12P123464.
    HGNCi HGNC:18076. ARL6IP4.
    HPAi HPA052098.
    MIMi 607668. gene.
    neXtProti NX_Q66PJ3.
    PharmGKBi PA134879338.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83556.
    HOVERGENi HBG102109.
    OMAi WHRSAEE.
    PhylomeDBi Q66PJ3.
    TreeFami TF350468.

    Miscellaneous databases

    ChiTaRSi ARL6IP4. human.
    GeneWikii ARL6IP4.
    GenomeRNAii 51329.
    NextBioi 35470743.
    PROi Q66PJ3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q66PJ3.
    CleanExi HS_ARL6IP4.
    Genevestigatori Q66PJ3.

    Family and domain databases

    InterProi IPR019532. Nucl_RNA-splicing_assoc_SR-25.
    [Graphical view ]
    Pfami PF10500. SR-25. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SRrp37, a novel splicing regulator located in the nuclear speckles and nucleoli, interacts with SC35 and modulates alternative pre-mRNA splicing in vivo."
      Ouyang P.
      J. Cell. Biochem. 108:304-314(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 7), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SRSF2 AND ZCCHC17, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-421 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 175-421 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 176-421 (ISOFORM 4).
      Tissue: Brain, Eye, Skin and Uterus.
    5. "An SR-protein induced by HSVI binding to cells functioning as a splicing inhibitor of viral pre-mRNA."
      Li Q., Zhao H., Jiang L., Che Y., Dong C., Wang L., Wang J., Liu L.
      J. Mol. Biol. 316:887-894(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-421 (ISOFORM 6), POSSIBLE FUNCTION, PHOSPHORYLATION, DEVELOPMENTAL STAGE, INDUCTION.
      Tissue: Lung.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 165-421 (ISOFORM 3).
    7. Zhou G., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Lin L., Yang S.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-421 (ISOFORM 5).
    8. "Searching for interaction partners of the transcription factor REST/NRSF by two-hybrid screening."
      Santana-Roman H., Curiel-Quesada E., Tapia-Ramirez J.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 190-287 (ISOFORM 2).
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Screening of human SNP database identifies recoding sites of A-to-I RNA editing."
      Gommans W.M., Tatalias N.E., Sie C.P., Dupuis D., Vendetti N., Smith L., Kaushal R., Maas S.
      RNA 14:2074-2085(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA EDITING OF POSITION 225.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAR6P4_HUMAN
    AccessioniPrimary (citable) accession number: Q66PJ3
    Secondary accession number(s): A4UCR8
    , B3V0L0, B3V0L1, Q4F966, Q504R8, Q96BI2, Q9NR05, Q9P2R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: July 9, 2014
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-62 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3