Reviewed, UniProtKB/Swiss-Prot Q66PG4 (LARG2_CHICK)

Names and origin

Protein names

Recommended name:
    Glycosyltransferase-like protein LARGE2
    EC=2.4.-.-
Alternative name(s):
    Glycosyltransferase-like 1B

Gene names

Name:

GYLTL1B

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	739 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Glycosyltransferase which participates in glycosylation of alpha-dystroglycan. May carry out the synthesis of glycoprotein and glycosphingolipid sugar chains By similarity.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 8 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 739	739	Glycosyltransferase-like protein LARGE2		PRO_0000226814
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Signal-anchor for type II membrane protein Potential
	Topological domain	32 – 739	708	Lumenal Potential
Amino acid modifications
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
	Glycosylation	217	1	N-linked (GlcNAc...) Potential
	Glycosylation	255	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q66PG4-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: CF65F7C0E65414AE	FASTA	739	85,568
	10 20 30 40 50 60 MLCSWRVKLK LLLATITLAV LLSWLYLFVG SLEYGRFLLL PPCLGEQPSR DVEREALASQ 70 80 90 100 110 120 VRRVEEENQQ LRMQLGQVQA EGSDGNPQWA ASAEDGPPLG GERNNRTACP EQRMVRKCEL 130 140 150 160 170 180 LHVAIVCAGH NASRDVVTLV KSILFHRKNP LHFHFITDSV AHQILQTLFQ SWMVPSIHVS 190 200 210 220 230 240 FYNADDLKPE VSWIPNKHYS GIYGLMKLTL TKALPSNLSK VIVLDTDITF ATDIAELWAV 250 260 270 280 290 300 FGKFSEKQVI GLVENQSDWY LGNLWKNHKP WPALGRGFNT GVILLLLDRL RRLGWEQMWR 310 320 330 340 350 360 LTAERELMSM LSTSLADQDI FNAVIKQNPA LVYRLPCFWN VQLSDHTRSE LCYTEVSDLK 370 380 390 400 410 420 VIHWNSPKKL RVKNKHVEFF RNLYLTFLEY DGNLLRRELF GCASLPSPPS DQLQQALEEL 430 440 450 460 470 480 DEDDPCYDFR RQHLTQHRVH LFFLQYEFLA LPNPTDVTLV AQLSMDRLQM LEAICKHWAG 490 500 510 520 530 540 PISLALYMSD AEAQQFLRYA QASEVLSARR NVAYHIVYKE GQFYPINLLR NVALANTQTP 550 560 570 580 590 600 YVFLTDIDFL PMYGLYDYLR NSIQQLELPH RKAALIVPAF ETLHYRLTFP KSKAELLSML 610 620 630 640 650 660 DMGSLYTFRY HVWPKGHAPT DYAKWRTATV PYRVAWQPDF EPYVVVRRDC PKYDQRFVGF 670 680 690 700 710 720 GWNKVSHIME LDAQEYELLV LPNAFMIHMP HAPSFDISKF RLSAGYRGCL QTLREEFHQD 730 LSRKYGAAAL KYLTAERNL

References

[1]	"Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies." Grewal P.K., McLaughlan J.M., Moore C.J., Browning C.A., Hewitt J.E. Glycobiology 15:912-923(2005) [PubMed: 15958417] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY662336 mRNA. Translation: AAU12249.1.
IPI	IPI00821884.
RefSeq	NP_001004404.1.
UniGene	Gga.15229
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q66PG4.
Protein family/group databases
CAZy	GT49. Glycosyltransferase Family 49. GT8. Glycosyltransferase Family 8.
Genome annotation databases
Ensembl	ENSGALT00000038363; ENSGALP00000037568; ENSGALG00000008418; Gallus gallus. [Genome view]
GeneID	423200.
KEGG	gga:423200.
Organism-specific databases
CTD	423200.
Phylogenomic databases
HOVERGEN	Q66PG4.
Family and domain databases
InterPro	IPR002495. Glyco_trans_8. [Graphical view]
Pfam	PF01501. Glyco_transf_8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LARG2_CHICK

Accession

Primary (citable) accession number: Q66PG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	October 11, 2004
Last modified:	November 24, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)