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Protein
Submitted name:

CENP-C

Gene

Cenpc

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. centromeric DNA binding Source: InterPro

GO - Biological processi

  1. kinetochore assembly Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CENP-CImported
Gene namesi
Name:CenpcImported
Synonyms:Cenpc1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1303061. Cenpc.

Subcellular locationi

GO - Cellular componenti

  1. kinetochore Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ66LH7.

Expressioni

Gene expression databases

GenevestigatoriQ66LH7.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4X23X-ray3.50U/V/W/X710-734[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG259274.
HOGENOMiHOG000090256.
HOVERGENiHBG050891.
KOiK11497.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR028386. CENP-C/Mif2/cnp3.
IPR028931. CENP-C_mid.
IPR028052. CENP_C_N_dom.
IPR025974. Mif2/CENP-C_cupin.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR16684. PTHR16684. 1 hit.
PfamiPF11699. CENP-C_C. 1 hit.
PF15620. CENP-C_mid. 1 hit.
PF15622. CENP_C_N. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66LH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFHLDHLK NYHRRFCRPS RAPNIPTKQG QNMLEILQDC FEEQNSTESL
60 70 80 90 100
SCSTPKEKDI YVQSTGKERQ ASHSESVPIS SRRKEASLQV PAKPSDPADE
110 120 130 140 150
PVQANEVHQK ILSTDVVSKS TPDSTKTSSK GVKGHHGASD ELYLPGGSPV
160 170 180 190 200
VLLGARVSGS QKAISSGGQK RVTSRRSADM QSSNTDISFK TRKRLNFEDK
210 220 230 240 250
VISNTAEIES SASQVEDSIS EEQEGTSSET SQKRDDLSSE IQPQSKKSFS
260 270 280 290 300
ELYLETVNRK SKCSSVVRHT AAVPSPPYPP NDMKLLEDEF IIDGPDRSFS
310 320 330 340 350
SQPWVVIPRK GHHMPFPENI AVPQGKKSRE KPHRLSEKTL VSNTQTDKTG
360 370 380 390 400
PVEEAQLSVE EKLGTTLTNE LENDCRSTEN KTHSENAKKP SARKRTVKQK
410 420 430 440 450
QRRPSKPNIA QELSMGQNET ENRNMSKIGQ DKLQINSKRN MEDHEEVRNE
460 470 480 490 500
PTPKKPVPAL GNKKEKDSTQ ANKEKSRKKC FSRESKRKSV PKEVTLASRR
510 520 530 540 550
GRRTSQHPSE WWLVKPSEGS VDGNSSKENE SSILYPNRKK QTKRNHVSEN
560 570 580 590 600
TEKKPVPSKR KKKEISSREL KSLNVKGSGG NDDISTSQRK PLQNIDADPT
610 620 630 640 650
QKSLHCSGPT RGSEDQNSDM ISQNVHLKTR SEQHRSKTQM ESTSNSEVCK
660 670 680 690 700
HSVWEESGPS RFKNLEMPGR SNSEVGDEKD QKSLDLKTRS SNMVPNRNLH
710 720 730 740 750
HKLVLPSNSP NVRRSNRIRL KPLEYWRGER IDYQESSSGR LVLEIVSPAS
760 770 780 790 800
ESVKRKAKRN LDKVNKETNK KRIHLDNPTK TKIKVSLDIP LGDPFQATLA
810 820 830 840 850
KDPETREIVP MDLIRPRDTY HFFVEQHGLK VYKTLNTTFF STGKLVLGPH
860 870 880 890 900
EEKGKQHVGQ DILVFYVNFG DLLCTLHETP YMLTTGDSFY VPSGNHYNIK
910
NLLNVESCLL FTQIKR
Length:916
Mass (Da):103,334
Last modified:October 11, 2004 - v1
Checksum:i015E3614EC926C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY693788 mRNA. Translation: AAU04621.1.
RefSeqiNP_001004098.1. NM_001004098.1.
UniGeneiRn.85211.

Genome annotation databases

GeneIDi305270.
KEGGirno:305270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY693788 mRNA. Translation: AAU04621.1.
RefSeqiNP_001004098.1. NM_001004098.1.
UniGeneiRn.85211.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4X23X-ray3.50U/V/W/X710-734[»]
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ66LH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi305270.
KEGGirno:305270.

Organism-specific databases

CTDi1060.
RGDi1303061. Cenpc.

Phylogenomic databases

eggNOGiNOG259274.
HOGENOMiHOG000090256.
HOVERGENiHBG050891.
KOiK11497.

Miscellaneous databases

NextBioi654308.

Gene expression databases

GenevestigatoriQ66LH7.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR028386. CENP-C/Mif2/cnp3.
IPR028931. CENP-C_mid.
IPR028052. CENP_C_N_dom.
IPR025974. Mif2/CENP-C_cupin.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR16684. PTHR16684. 1 hit.
PfamiPF11699. CENP-C_C. 1 hit.
PF15620. CENP-C_mid. 1 hit.
PF15622. CENP_C_N. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Adaptive evolution of centromere proteins in plants and animals."
    Talbert P.B., Bryson T.D., Henikoff S.
    J. Biol. 3:18-18(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. "A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C."
    Kato H., Jiang J., Zhou B.R., Rozendaal M., Feng H., Ghirlando R., Xiao T.S., Straight A.F., Bai Y.
    Science 340:1110-1113(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) OF 710-734.

Entry informationi

Entry nameiQ66LH7_RAT
AccessioniPrimary (citable) accession number: Q66LH7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 4, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.