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Reviewed, UniProtKB/Swiss-Prot Q66LE6 (2ABD_HUMAN)

Last modified February 9, 2010. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Alternative name(s):
    PP2A subunit B isoform delta
    PP2A subunit B isoform B55-delta
    PP2A subunit B isoform PR55-delta
    PP2A subunit B isoform R2-delta
Gene names
Name: PPP2R2D
Synonyms: KIAA1541
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment By similarity.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the phosphatase 2A regulatory subunit B family.

Contains 7 WD repeats.

Sequence caution

The sequence CAI16703.1 differs from that shown. Reason: Erroneous gene model prediction.

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Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   DomainRepeat
WD repeat
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

protein phosphatase type 2A complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein phosphatase type 2A regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
PRO_0000071433

Regions

Repeat32 – 7140WD 1
Repeat97 – 13842WD 2
Repeat181 – 21939WD 3
Repeat230 – 27041WD 4
Repeat289 – 32739WD 5
Repeat344 – 38542WD 6
Repeat420 – 45233WD 7
Compositional bias3 – 86Poly-Gly

Natural variations

Natural variant3581G → S: dbSNP rs34473884.
VAR_057127

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Sequences

Sequence LengthMass (Da)Tools
Q66LE6-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 0669CDB80AF4400E

FASTA45352,042
        10         20         30         40         50         60 
MAGAGGGGCP AGGNDFQWCF SQVKGAIDED VAEADIISTV EFNYSGDLLA TGDKGGRVVI 

        70         80         90        100        110        120 
FQREQENKSR PHSRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAHFLLST 

       130        140        150        160        170        180 
NDKTIKLWKI SERDKRAEGY NLKDEDGRLR DPFRITALRV PILKPMDLMV EASPRRIFAN 

       190        200        210        220        230        240 
AHTYHINSIS VNSDHETYLS ADDLRINLWH LEITDRSFNI VDIKPANMEE LTEVITAAEF 

       250        260        270        280        290        300 
HPHQCNVFVY SSSKGTIRLC DMRSSALCDR HSKFFEEPED PSSRSFFSEI ISSISDVKFS 

       310        320        330        340        350        360 
HSGRYMMTRD YLSVKVWDLN MESRPVETHQ VHEYLRSKLC SLYENDCIFD KFECCWNGSD 

       370        380        390        400        410        420 
SAIMTGSYNN FFRMFDRDTR RDVTLEASRE SSKPRASLKP RKVCTGGKRR KDEISVDSLD 

       430        440        450 
FNKKILHTAW HPVDNVIAVA ATNNLYIFQD KIN

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References

[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-453.
Tissue: Brain.
[4]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL732395 Genomic DNA. Translation: CAI16703.1. Sequence problems.
BC047379 mRNA. Translation: AAH47379.1.
AB040974 mRNA. Translation: BAA96065.1. Different initiation.
IPIIPI00470920.
RefSeqNP_001003656.1.
NP_060931.2.
UniGeneHs.380372
Hs.657480

3D structure databases

SMRQ66LE6. Positions 32-379, 34-442, 84-449.
ModBaseSearch...

Protein-protein interaction databases

IntActQ66LE6. 23 interactions.
STRINGQ66LE6.

Proteomic databases

PRIDEQ66LE6.

Genome annotation databases

EnsemblENST00000314348; ENSP00000319975; ENSG00000175470; Homo sapiens. [Genome view]
ENST00000455566; ENSP00000399970; ENSG00000175470; Homo sapiens. [Genome view]
GeneID55844.
KEGGhsa:55844.
UCSCuc001lks.1. human.

Organism-specific databases

CTD55844.
GeneCardsGC10P133597.
H-InvDBHIX0080308.
HGNCHGNC:23732. PPP2R2D.
PharmGKBPA134899040.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG12596.
HOGENOMHBG443924.
HOVERGENQ66LE6.
InParanoidQ66LE6.
PhylomeDBQ66LE6.

Gene expression databases

ArrayExpressQ66LE6.
BgeeQ66LE6.
CleanExHS_PPP2R2D.
GenevestigatorQ66LE6.
GermOnlineENSG00000175470. Homo sapiens.

Family and domain databases

InterProIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019781. WD40_repeat_sg.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PANTHERPTHR11871. Pp2A_PR55. 1 hit.
PfamPF00400. WD40. 1 hit.
[Graphical view]
PIRSFPIRSF037309. PP2A_PR55. 1 hit.
PRINTSPR00600. PP2APR55.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
PROSITEPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. False negative.
PS50294. WD_REPEATS_REGION. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio61085.

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Entry information

Entry name2ABD_HUMAN
AccessionPrimary (citable) accession number: Q66LE6
Secondary accession number(s): Q5SQJ2, Q9P1Y7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 11, 2004
Last modified: February 9, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents