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Q66LE6

- 2ABD_HUMAN

UniProt

Q66LE6 - 2ABD_HUMAN

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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

Gene

PPP2R2D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).By similarity

GO - Molecular functioni

  1. protein phosphatase type 2A regulator activity Source: UniProtKB

GO - Biological processi

  1. exit from mitosis Source: UniProtKB
  2. mitotic cell cycle Source: Reactome
  3. mitotic nuclear division Source: UniProtKB
  4. regulation of catalytic activity Source: GOC
  5. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiREACT_150182. MASTL Facilitates Mitotic Progression.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Alternative name(s):
PP2A subunit B isoform B55-delta
PP2A subunit B isoform PR55-delta
PP2A subunit B isoform R2-delta
PP2A subunit B isoform delta
Gene namesi
Name:PPP2R2D
Synonyms:KIAA1541
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23732. PPP2R2D.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. protein phosphatase type 2A complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformPRO_0000071433Add
BLAST

Proteomic databases

MaxQBiQ66LE6.
PaxDbiQ66LE6.
PRIDEiQ66LE6.

PTM databases

PhosphoSiteiQ66LE6.

Expressioni

Gene expression databases

BgeeiQ66LE6.
CleanExiHS_PPP2R2D.
ExpressionAtlasiQ66LE6. baseline and differential.
GenevestigatoriQ66LE6.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity).By similarity

Protein-protein interaction databases

BioGridi120946. 50 interactions.
IntActiQ66LE6. 27 interactions.
MINTiMINT-2820413.
STRINGi9606.ENSP00000381100.

Structurei

3D structure databases

ProteinModelPortaliQ66LE6.
SMRiQ66LE6. Positions 14-452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati32 – 7140WD 1Add
BLAST
Repeati97 – 13842WD 2Add
BLAST
Repeati181 – 21939WD 3Add
BLAST
Repeati230 – 27041WD 4Add
BLAST
Repeati289 – 32739WD 5Add
BLAST
Repeati344 – 38542WD 6Add
BLAST
Repeati420 – 45233WD 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 86Poly-Gly

Sequence similaritiesi

Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG5170.
GeneTreeiENSGT00390000006311.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
InParanoidiQ66LE6.
KOiK04354.
PhylomeDBiQ66LE6.
TreeFamiTF105553.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66LE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGAGGGGCP AGGNDFQWCF SQVKGAIDED VAEADIISTV EFNYSGDLLA
60 70 80 90 100
TGDKGGRVVI FQREQENKSR PHSRGEYNVY STFQSHEPEF DYLKSLEIEE
110 120 130 140 150
KINKIRWLPQ QNAAHFLLST NDKTIKLWKI SERDKRAEGY NLKDEDGRLR
160 170 180 190 200
DPFRITALRV PILKPMDLMV EASPRRIFAN AHTYHINSIS VNSDHETYLS
210 220 230 240 250
ADDLRINLWH LEITDRSFNI VDIKPANMEE LTEVITAAEF HPHQCNVFVY
260 270 280 290 300
SSSKGTIRLC DMRSSALCDR HSKFFEEPED PSSRSFFSEI ISSISDVKFS
310 320 330 340 350
HSGRYMMTRD YLSVKVWDLN MESRPVETHQ VHEYLRSKLC SLYENDCIFD
360 370 380 390 400
KFECCWNGSD SAIMTGSYNN FFRMFDRDTR RDVTLEASRE SSKPRASLKP
410 420 430 440 450
RKVCTGGKRR KDEISVDSLD FNKKILHTAW HPVDNVIAVA ATNNLYIFQD

KIN
Length:453
Mass (Da):52,042
Last modified:October 11, 2004 - v1
Checksum:i0669CDB80AF4400E
GO

Sequence cautioni

The sequence BAA96065.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI16703.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901I → V in BAF85754. (PubMed:14702039)Curated
Sequence conflicti311 – 3111Y → H in BAF85754. (PubMed:14702039)Curated
Sequence conflicti321 – 3211M → T in BAF85754. (PubMed:14702039)Curated
Sequence conflicti449 – 4491Q → R in BAF85754. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti358 – 3581G → S.
Corresponds to variant rs34473884 [ dbSNP | Ensembl ].
VAR_057127

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK293065 mRNA. Translation: BAF85754.1.
AL732395 Genomic DNA. Translation: CAI16703.1. Sequence problems.
BC047379 mRNA. Translation: AAH47379.1.
AB040974 mRNA. Translation: BAA96065.1. Different initiation.
CCDSiCCDS73224.1.
RefSeqiNP_001278239.1. NM_001291310.1.
NP_060931.2. NM_018461.4.
UniGeneiHs.380372.
Hs.657480.

Genome annotation databases

EnsembliENST00000616467; ENSP00000481133; ENSG00000175470.
GeneIDi55844.
KEGGihsa:55844.
UCSCiuc001lks.3. human.

Polymorphism databases

DMDMi74736328.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK293065 mRNA. Translation: BAF85754.1 .
AL732395 Genomic DNA. Translation: CAI16703.1 . Sequence problems.
BC047379 mRNA. Translation: AAH47379.1 .
AB040974 mRNA. Translation: BAA96065.1 . Different initiation.
CCDSi CCDS73224.1.
RefSeqi NP_001278239.1. NM_001291310.1.
NP_060931.2. NM_018461.4.
UniGenei Hs.380372.
Hs.657480.

3D structure databases

ProteinModelPortali Q66LE6.
SMRi Q66LE6. Positions 14-452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120946. 50 interactions.
IntActi Q66LE6. 27 interactions.
MINTi MINT-2820413.
STRINGi 9606.ENSP00000381100.

PTM databases

PhosphoSitei Q66LE6.

Polymorphism databases

DMDMi 74736328.

Proteomic databases

MaxQBi Q66LE6.
PaxDbi Q66LE6.
PRIDEi Q66LE6.

Protocols and materials databases

DNASUi 55844.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000616467 ; ENSP00000481133 ; ENSG00000175470 .
GeneIDi 55844.
KEGGi hsa:55844.
UCSCi uc001lks.3. human.

Organism-specific databases

CTDi 55844.
GeneCardsi GC10P133747.
H-InvDB HIX0009317.
HGNCi HGNC:23732. PPP2R2D.
MIMi 613992. gene.
neXtProti NX_Q66LE6.
PharmGKBi PA134899040.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5170.
GeneTreei ENSGT00390000006311.
HOGENOMi HOG000089745.
HOVERGENi HBG000012.
InParanoidi Q66LE6.
KOi K04354.
PhylomeDBi Q66LE6.
TreeFami TF105553.

Enzyme and pathway databases

Reactomei REACT_150182. MASTL Facilitates Mitotic Progression.

Miscellaneous databases

ChiTaRSi PPP2R2D. human.
GenomeRNAii 55844.
NextBioi 61085.
PROi Q66LE6.
SOURCEi Search...

Gene expression databases

Bgeei Q66LE6.
CleanExi HS_PPP2R2D.
ExpressionAtlasi Q66LE6. baseline and differential.
Genevestigatori Q66LE6.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR11871. PTHR11871. 1 hit.
PIRSFi PIRSF037309. PP2A_PR55. 1 hit.
PRINTSi PR00600. PP2APR55.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 3 hits.
PROSITEi PS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-453.
    Tissue: Brain.

Entry informationi

Entry namei2ABD_HUMAN
AccessioniPrimary (citable) accession number: Q66LE6
Secondary accession number(s): A8KAK0, Q5SQJ2, Q9P1Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3