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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

Gene

PPP2R2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2465910 MASTL Facilitates Mitotic Progression
SIGNORiQ66LE6

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Alternative name(s):
PP2A subunit B isoform B55-delta
PP2A subunit B isoform PR55-delta
PP2A subunit B isoform R2-delta
PP2A subunit B isoform delta
Gene namesi
Name:PPP2R2D
Synonyms:KIAA1541
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000175470.18
HGNCiHGNC:23732 PPP2R2D
MIMi613992 gene
neXtProtiNX_Q66LE6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55844
OpenTargetsiENSG00000175470
PharmGKBiPA134899040

Polymorphism and mutation databases

BioMutaiPPP2R2D
DMDMi74736328

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714331 – 453Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285PhosphoserineBy similarity1
Modified residuei305PhosphotyrosineBy similarity1
Modified residuei308PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ66LE6
MaxQBiQ66LE6
PaxDbiQ66LE6
PeptideAtlasiQ66LE6
PRIDEiQ66LE6

PTM databases

iPTMnetiQ66LE6
PhosphoSitePlusiQ66LE6

Expressioni

Gene expression databases

BgeeiENSG00000175470
CleanExiHS_PPP2R2D
ExpressionAtlasiQ66LE6 baseline and differential
GenevisibleiQ66LE6 HS

Organism-specific databases

HPAiHPA042122
HPA042770

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity). Interacts with IER5 (PubMed:25816751).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120946103 interactors.
IntActiQ66LE6 55 interactors.
MINTiQ66LE6
STRINGi9606.ENSP00000399970

Structurei

3D structure databases

ProteinModelPortaliQ66LE6
SMRiQ66LE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati32 – 71WD 1Add BLAST40
Repeati97 – 138WD 2Add BLAST42
Repeati181 – 219WD 3Add BLAST39
Repeati230 – 270WD 4Add BLAST41
Repeati289 – 327WD 5Add BLAST39
Repeati344 – 385WD 6Add BLAST42
Repeati420 – 452WD 7Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 8Poly-Gly6

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
GeneTreeiENSGT00390000006311
HOGENOMiHOG000089745
HOVERGENiHBG000012
InParanoidiQ66LE6
KOiK04354
OMAiMFDRNTR
OrthoDBiEOG091G09BB
PhylomeDBiQ66LE6
TreeFamiTF105553

Family and domain databases

Gene3Di2.130.10.101 hit
InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q66LE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAGGGGCP AGGNDFQWCF SQVKGAIDED VAEADIISTV EFNYSGDLLA
60 70 80 90 100
TGDKGGRVVI FQREQENKSR PHSRGEYNVY STFQSHEPEF DYLKSLEIEE
110 120 130 140 150
KINKIRWLPQ QNAAHFLLST NDKTIKLWKI SERDKRAEGY NLKDEDGRLR
160 170 180 190 200
DPFRITALRV PILKPMDLMV EASPRRIFAN AHTYHINSIS VNSDHETYLS
210 220 230 240 250
ADDLRINLWH LEITDRSFNI VDIKPANMEE LTEVITAAEF HPHQCNVFVY
260 270 280 290 300
SSSKGTIRLC DMRSSALCDR HSKFFEEPED PSSRSFFSEI ISSISDVKFS
310 320 330 340 350
HSGRYMMTRD YLSVKVWDLN MESRPVETHQ VHEYLRSKLC SLYENDCIFD
360 370 380 390 400
KFECCWNGSD SAIMTGSYNN FFRMFDRDTR RDVTLEASRE SSKPRASLKP
410 420 430 440 450
RKVCTGGKRR KDEISVDSLD FNKKILHTAW HPVDNVIAVA ATNNLYIFQD

KIN
Length:453
Mass (Da):52,042
Last modified:October 11, 2004 - v1
Checksum:i0669CDB80AF4400E
GO

Sequence cautioni

The sequence BAA96065 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI16703 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290I → V in BAF85754 (PubMed:14702039).Curated1
Sequence conflicti311Y → H in BAF85754 (PubMed:14702039).Curated1
Sequence conflicti321M → T in BAF85754 (PubMed:14702039).Curated1
Sequence conflicti449Q → R in BAF85754 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057127358G → S. Corresponds to variant dbSNP:rs34473884Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293065 mRNA Translation: BAF85754.1
AL732395 Genomic DNA Translation: CAI16703.1 Sequence problems.
BC047379 mRNA Translation: AAH47379.1
AB040974 mRNA Translation: BAA96065.1 Different initiation.
CCDSiCCDS73224.1
RefSeqiNP_001278239.1, NM_001291310.1
NP_060931.2, NM_018461.4
UniGeneiHs.380372
Hs.657480

Genome annotation databases

EnsembliENST00000455566; ENSP00000399970; ENSG00000175470
GeneIDi55844
KEGGihsa:55844
UCSCiuc031wxk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei2ABD_HUMAN
AccessioniPrimary (citable) accession number: Q66LE6
Secondary accession number(s): A8KAK0, Q5SQJ2, Q9P1Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome