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Protein
Submitted name:

Transglutaminase 2, C polypeptide

Gene

tgm2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+UniRule annotationNote: Binds 1 Ca2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei271UniRule annotation1
Active sitei327UniRule annotation1
Active sitei350UniRule annotation1
Metal bindingi390CalciumUniRule annotation1
Metal bindingi392CalciumUniRule annotation1
Metal bindingi439CalciumUniRule annotation1
Metal bindingi444CalciumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transglutaminase 2, C polypeptideImported
Gene namesi
Name:tgm2aImported
Synonyms:tgm2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040912-78 tgm2a

Structurei

3D structure databases

ProteinModelPortaliQ66L63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 353TGcInterPro annotationAdd BLAST91

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
HOGENOMiHOG000231695
HOVERGENiHBG004342
KOiK05625
PhylomeDBiQ66L63

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q66L63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVVEIGSI DLACEVNNTN HHTHLNGVDR LIVRRGQTFT IHLHLKEGTH
60 70 80 90 100
FQNGDNIKFI AQTGPIPSVE AQTKARFSLS KVISRLSWSA TAETHNSTVS
110 120 130 140 150
LSICAHTNAP VGRYTLILDQ GDGVILGEFV LLFNPWGKLD SVYLANEAER
160 170 180 190 200
EEYVLSQDGL IYRGTPKRIT VLPWTFGQFE HGILDICLQI LDESPNYISD
210 220 230 240 250
AALDCSERKN AVYVTRVLSA MINSLGDKGV VVGNWSDDYE DGVKPTVWKD
260 270 280 290 300
SCSILRQWSN EGCRAVRYGQ CWVFAAVACT VSRALGIPCR VITNFGSARD
310 320 330 340 350
SNGDLIMERF YNEFDENIAD DSIWNYHVWV ENWMTRPDLA LGYEGWQASD
360 370 380 390 400
PTPQHRSDGV FCCGPASVRA IKEGELTFKF DVPFVYAEVN ADVVEYIKLR
410 420 430 440 450
DGRVFKMGGS TTEIGKSIST KAVGRDERED ITHNYKYPEG SEEERKVFKK
460 470 480 490 500
ANHHNKLAQA GEEPGLHIKI RVTPDMQIGS DFDVYAEIKN NTMVTKSCRV
510 520 530 540 550
MFYAQAVSYN GTLGETCGLG DFTEMSLASS DGGKVTLRLE YAEYSKAITQ
560 570 580 590 600
DRMIKLVGLL IDAETREFYR AKKTIVLDAP EIIVNILGVP KVGRNLVADL
610 620 630 640 650
ALQNPLPEPL ENCVFTIHGA NLTDGKPITH EVGTIGPKEF ATAKVEFAPK
660 670
LPGQRKLIID FASDKLHNIE TYENLVIYE
Length:679
Mass (Da):75,756
Last modified:October 11, 2004 - v1
Checksum:i0CF6744DAE4E8F27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078420 mRNA Translation: AAH78420.1
RefSeqiNP_001004647.1, NM_001004647.2
UniGeneiDr.88666

Genome annotation databases

GeneIDi447909
KEGGidre:447909

Similar proteinsi

Entry informationi

Entry nameiQ66L63_DANRE
AccessioniPrimary (citable) accession number: Q66L63
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health