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Q66L63

- Q66L63_DANRE

UniProt

Q66L63 - Q66L63_DANRE

Protein
Submitted name:

Transglutaminase 2, C polypeptide

Gene

tgm2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 calcium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei271 – 2711UniRule annotation
    Active sitei327 – 3271UniRule annotation
    Active sitei350 – 3501UniRule annotation
    Metal bindingi390 – 3901Calcium
    Metal bindingi392 – 3921Calcium
    Metal bindingi439 – 4391Calcium
    Metal bindingi444 – 4441Calcium

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro

    GO - Biological processi

    1. peptide cross-linking Source: InterPro

    Keywords - Ligandi

    CalciumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Transglutaminase 2, C polypeptideImported
    Gene namesi
    Name:tgm2aImported
    Synonyms:tgm2Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

    Organism-specific databases

    ZFINiZDB-GENE-040912-78. tgm2a.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ66L63.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000093487.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66L63.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG80379.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    InParanoidiQ66L63.
    KOiK05625.
    PhylomeDBiQ66L63.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q66L63-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERVVEIGSI DLACEVNNTN HHTHLNGVDR LIVRRGQTFT IHLHLKEGTH    50
    FQNGDNIKFI AQTGPIPSVE AQTKARFSLS KVISRLSWSA TAETHNSTVS 100
    LSICAHTNAP VGRYTLILDQ GDGVILGEFV LLFNPWGKLD SVYLANEAER 150
    EEYVLSQDGL IYRGTPKRIT VLPWTFGQFE HGILDICLQI LDESPNYISD 200
    AALDCSERKN AVYVTRVLSA MINSLGDKGV VVGNWSDDYE DGVKPTVWKD 250
    SCSILRQWSN EGCRAVRYGQ CWVFAAVACT VSRALGIPCR VITNFGSARD 300
    SNGDLIMERF YNEFDENIAD DSIWNYHVWV ENWMTRPDLA LGYEGWQASD 350
    PTPQHRSDGV FCCGPASVRA IKEGELTFKF DVPFVYAEVN ADVVEYIKLR 400
    DGRVFKMGGS TTEIGKSIST KAVGRDERED ITHNYKYPEG SEEERKVFKK 450
    ANHHNKLAQA GEEPGLHIKI RVTPDMQIGS DFDVYAEIKN NTMVTKSCRV 500
    MFYAQAVSYN GTLGETCGLG DFTEMSLASS DGGKVTLRLE YAEYSKAITQ 550
    DRMIKLVGLL IDAETREFYR AKKTIVLDAP EIIVNILGVP KVGRNLVADL 600
    ALQNPLPEPL ENCVFTIHGA NLTDGKPITH EVGTIGPKEF ATAKVEFAPK 650
    LPGQRKLIID FASDKLHNIE TYENLVIYE 679
    Length:679
    Mass (Da):75,756
    Last modified:October 11, 2004 - v1
    Checksum:i0CF6744DAE4E8F27
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078420 mRNA. Translation: AAH78420.1.
    RefSeqiNP_001004647.1. NM_001004647.2.
    UniGeneiDr.88666.

    Genome annotation databases

    GeneIDi447909.
    KEGGidre:447909.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078420 mRNA. Translation: AAH78420.1 .
    RefSeqi NP_001004647.1. NM_001004647.2.
    UniGenei Dr.88666.

    3D structure databases

    ProteinModelPortali Q66L63.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000093487.

    Proteomic databases

    PRIDEi Q66L63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 447909.
    KEGGi dre:447909.

    Organism-specific databases

    CTDi 447909.
    ZFINi ZDB-GENE-040912-78. tgm2a.

    Phylogenomic databases

    eggNOGi NOG80379.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    InParanoidi Q66L63.
    KOi K05625.
    PhylomeDBi Q66L63.

    Miscellaneous databases

    NextBioi 20832428.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Singapore local strainImported.
      Tissue: EmbryoImported.

    Entry informationi

    Entry nameiQ66L63_DANRE
    AccessioniPrimary (citable) accession number: Q66L63
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)