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Q66L63

- Q66L63_DANRE

UniProt

Q66L63 - Q66L63_DANRE

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Protein
Submitted name:

Transglutaminase 2, C polypeptide

Gene
tgm2a, tgm2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 calcium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei271 – 2711 By similarityUniRule annotation
Active sitei327 – 3271 By similarityUniRule annotation
Active sitei350 – 3501 By similarityUniRule annotation
Metal bindingi390 – 3901Calcium By similarityUniRule annotation
Metal bindingi392 – 3921Calcium By similarityUniRule annotation
Metal bindingi439 – 4391Calcium By similarityUniRule annotation
Metal bindingi444 – 4441Calcium By similarityUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transglutaminase 2, C polypeptideImported
Gene namesi
Name:tgm2aImported
Synonyms:tgm2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040912-78. tgm2a.

PTM / Processingi

Proteomic databases

PRIDEiQ66L63.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093487.

Structurei

3D structure databases

ProteinModelPortaliQ66L63.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiQ66L63.
KOiK05625.
PhylomeDBiQ66L63.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66L63-1 [UniParc]FASTAAdd to Basket

« Hide

MERVVEIGSI DLACEVNNTN HHTHLNGVDR LIVRRGQTFT IHLHLKEGTH    50
FQNGDNIKFI AQTGPIPSVE AQTKARFSLS KVISRLSWSA TAETHNSTVS 100
LSICAHTNAP VGRYTLILDQ GDGVILGEFV LLFNPWGKLD SVYLANEAER 150
EEYVLSQDGL IYRGTPKRIT VLPWTFGQFE HGILDICLQI LDESPNYISD 200
AALDCSERKN AVYVTRVLSA MINSLGDKGV VVGNWSDDYE DGVKPTVWKD 250
SCSILRQWSN EGCRAVRYGQ CWVFAAVACT VSRALGIPCR VITNFGSARD 300
SNGDLIMERF YNEFDENIAD DSIWNYHVWV ENWMTRPDLA LGYEGWQASD 350
PTPQHRSDGV FCCGPASVRA IKEGELTFKF DVPFVYAEVN ADVVEYIKLR 400
DGRVFKMGGS TTEIGKSIST KAVGRDERED ITHNYKYPEG SEEERKVFKK 450
ANHHNKLAQA GEEPGLHIKI RVTPDMQIGS DFDVYAEIKN NTMVTKSCRV 500
MFYAQAVSYN GTLGETCGLG DFTEMSLASS DGGKVTLRLE YAEYSKAITQ 550
DRMIKLVGLL IDAETREFYR AKKTIVLDAP EIIVNILGVP KVGRNLVADL 600
ALQNPLPEPL ENCVFTIHGA NLTDGKPITH EVGTIGPKEF ATAKVEFAPK 650
LPGQRKLIID FASDKLHNIE TYENLVIYE 679
Length:679
Mass (Da):75,756
Last modified:October 11, 2004 - v1
Checksum:i0CF6744DAE4E8F27
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078420 mRNA. Translation: AAH78420.1.
RefSeqiNP_001004647.1. NM_001004647.2.
UniGeneiDr.88666.

Genome annotation databases

GeneIDi447909.
KEGGidre:447909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078420 mRNA. Translation: AAH78420.1 .
RefSeqi NP_001004647.1. NM_001004647.2.
UniGenei Dr.88666.

3D structure databases

ProteinModelPortali Q66L63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000093487.

Proteomic databases

PRIDEi Q66L63.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 447909.
KEGGi dre:447909.

Organism-specific databases

CTDi 447909.
ZFINi ZDB-GENE-040912-78. tgm2a.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi Q66L63.
KOi K05625.
PhylomeDBi Q66L63.

Miscellaneous databases

NextBioi 20832428.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Singapore local strainImported.
    Tissue: EmbryoImported.

Entry informationi

Entry nameiQ66L63_DANRE
AccessioniPrimary (citable) accession number: Q66L63
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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