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Q66L63

- Q66L63_DANRE

UniProt

Q66L63 - Q66L63_DANRE

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Protein
Submitted name:

Transglutaminase 2, C polypeptide

Gene

tgm2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 calcium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei271 – 2711UniRule annotation
Active sitei327 – 3271UniRule annotation
Active sitei350 – 3501UniRule annotation
Metal bindingi390 – 3901Calcium
Metal bindingi392 – 3921Calcium
Metal bindingi439 – 4391Calcium
Metal bindingi444 – 4441Calcium

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transglutaminase 2, C polypeptideImported
Gene namesi
Name:tgm2aImported
Synonyms:tgm2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040912-78. tgm2a.

PTM / Processingi

Proteomic databases

PRIDEiQ66L63.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093487.

Structurei

3D structure databases

ProteinModelPortaliQ66L63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
KOiK05625.
PhylomeDBiQ66L63.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66L63-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERVVEIGSI DLACEVNNTN HHTHLNGVDR LIVRRGQTFT IHLHLKEGTH
60 70 80 90 100
FQNGDNIKFI AQTGPIPSVE AQTKARFSLS KVISRLSWSA TAETHNSTVS
110 120 130 140 150
LSICAHTNAP VGRYTLILDQ GDGVILGEFV LLFNPWGKLD SVYLANEAER
160 170 180 190 200
EEYVLSQDGL IYRGTPKRIT VLPWTFGQFE HGILDICLQI LDESPNYISD
210 220 230 240 250
AALDCSERKN AVYVTRVLSA MINSLGDKGV VVGNWSDDYE DGVKPTVWKD
260 270 280 290 300
SCSILRQWSN EGCRAVRYGQ CWVFAAVACT VSRALGIPCR VITNFGSARD
310 320 330 340 350
SNGDLIMERF YNEFDENIAD DSIWNYHVWV ENWMTRPDLA LGYEGWQASD
360 370 380 390 400
PTPQHRSDGV FCCGPASVRA IKEGELTFKF DVPFVYAEVN ADVVEYIKLR
410 420 430 440 450
DGRVFKMGGS TTEIGKSIST KAVGRDERED ITHNYKYPEG SEEERKVFKK
460 470 480 490 500
ANHHNKLAQA GEEPGLHIKI RVTPDMQIGS DFDVYAEIKN NTMVTKSCRV
510 520 530 540 550
MFYAQAVSYN GTLGETCGLG DFTEMSLASS DGGKVTLRLE YAEYSKAITQ
560 570 580 590 600
DRMIKLVGLL IDAETREFYR AKKTIVLDAP EIIVNILGVP KVGRNLVADL
610 620 630 640 650
ALQNPLPEPL ENCVFTIHGA NLTDGKPITH EVGTIGPKEF ATAKVEFAPK
660 670
LPGQRKLIID FASDKLHNIE TYENLVIYE
Length:679
Mass (Da):75,756
Last modified:October 11, 2004 - v1
Checksum:i0CF6744DAE4E8F27
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078420 mRNA. Translation: AAH78420.1.
RefSeqiNP_001004647.1. NM_001004647.2.
UniGeneiDr.88666.

Genome annotation databases

GeneIDi447909.
KEGGidre:447909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078420 mRNA. Translation: AAH78420.1 .
RefSeqi NP_001004647.1. NM_001004647.2.
UniGenei Dr.88666.

3D structure databases

ProteinModelPortali Q66L63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000093487.

Proteomic databases

PRIDEi Q66L63.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 447909.
KEGGi dre:447909.

Organism-specific databases

CTDi 447909.
ZFINi ZDB-GENE-040912-78. tgm2a.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
KOi K05625.
PhylomeDBi Q66L63.

Miscellaneous databases

NextBioi 20832428.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Singapore local strainImported.
    Tissue: EmbryoImported.

Entry informationi

Entry nameiQ66L63_DANRE
AccessioniPrimary (citable) accession number: Q66L63
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)