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Protein
Submitted name:

Transglutaminase 2, C polypeptide

Gene

tgm2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Note: Binds 1 calcium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei271 – 2711UniRule annotation
Active sitei327 – 3271UniRule annotation
Active sitei350 – 3501UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Transglutaminase 2, C polypeptideImported
Gene namesi
Name:tgm2aImported
Synonyms:tgm2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040912-78. tgm2a.

PTM / Processingi

Proteomic databases

PRIDEiQ66L63.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093487.

Structurei

3D structure databases

ProteinModelPortaliQ66L63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
KOiK05625.
PhylomeDBiQ66L63.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66L63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVVEIGSI DLACEVNNTN HHTHLNGVDR LIVRRGQTFT IHLHLKEGTH
60 70 80 90 100
FQNGDNIKFI AQTGPIPSVE AQTKARFSLS KVISRLSWSA TAETHNSTVS
110 120 130 140 150
LSICAHTNAP VGRYTLILDQ GDGVILGEFV LLFNPWGKLD SVYLANEAER
160 170 180 190 200
EEYVLSQDGL IYRGTPKRIT VLPWTFGQFE HGILDICLQI LDESPNYISD
210 220 230 240 250
AALDCSERKN AVYVTRVLSA MINSLGDKGV VVGNWSDDYE DGVKPTVWKD
260 270 280 290 300
SCSILRQWSN EGCRAVRYGQ CWVFAAVACT VSRALGIPCR VITNFGSARD
310 320 330 340 350
SNGDLIMERF YNEFDENIAD DSIWNYHVWV ENWMTRPDLA LGYEGWQASD
360 370 380 390 400
PTPQHRSDGV FCCGPASVRA IKEGELTFKF DVPFVYAEVN ADVVEYIKLR
410 420 430 440 450
DGRVFKMGGS TTEIGKSIST KAVGRDERED ITHNYKYPEG SEEERKVFKK
460 470 480 490 500
ANHHNKLAQA GEEPGLHIKI RVTPDMQIGS DFDVYAEIKN NTMVTKSCRV
510 520 530 540 550
MFYAQAVSYN GTLGETCGLG DFTEMSLASS DGGKVTLRLE YAEYSKAITQ
560 570 580 590 600
DRMIKLVGLL IDAETREFYR AKKTIVLDAP EIIVNILGVP KVGRNLVADL
610 620 630 640 650
ALQNPLPEPL ENCVFTIHGA NLTDGKPITH EVGTIGPKEF ATAKVEFAPK
660 670
LPGQRKLIID FASDKLHNIE TYENLVIYE
Length:679
Mass (Da):75,756
Last modified:October 11, 2004 - v1
Checksum:i0CF6744DAE4E8F27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078420 mRNA. Translation: AAH78420.1.
RefSeqiNP_001004647.1. NM_001004647.2.
UniGeneiDr.88666.

Genome annotation databases

GeneIDi447909.
KEGGidre:447909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078420 mRNA. Translation: AAH78420.1.
RefSeqiNP_001004647.1. NM_001004647.2.
UniGeneiDr.88666.

3D structure databases

ProteinModelPortaliQ66L63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000093487.

Proteomic databases

PRIDEiQ66L63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi447909.
KEGGidre:447909.

Organism-specific databases

CTDi447909.
ZFINiZDB-GENE-040912-78. tgm2a.

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
KOiK05625.
PhylomeDBiQ66L63.

Miscellaneous databases

NextBioi20832428.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Singapore local strainImported.
    Tissue: EmbryoImported.

Entry informationi

Entry nameiQ66L63_DANRE
AccessioniPrimary (citable) accession number: Q66L63
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.