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Q66L42

- M3K10_MOUSE

UniProt

Q66L42 - M3K10_MOUSE

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Protein
Mitogen-activated protein kinase kinase kinase 10
Gene
Map3k10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Activates the JUN N-terminal pathway By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251ATP By similarity
Active sitei222 – 2221Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1129ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProtKB-EC
  3. protein kinase activity Source: MGI
  4. transcription corepressor activity Source: MGI

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 10 (EC:2.7.11.25)
Gene namesi
Name:Map3k10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1346879. Map3k10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 940940Mitogen-activated protein kinase kinase kinase 10
PRO_0000277826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei258 – 2581Phosphothreonine; by autocatalysis By similarity
Modified residuei262 – 2621Phosphoserine; by autocatalysis and MAP4K1 By similarity
Modified residuei498 – 4981Phosphoserine By similarity
Modified residuei502 – 5021Phosphoserine By similarity
Modified residuei506 – 5061Phosphoserine By similarity
Modified residuei552 – 5521Phosphothreonine By similarity

Post-translational modificationi

Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ66L42.
PRIDEiQ66L42.

PTM databases

PhosphoSiteiQ66L42.

Expressioni

Gene expression databases

BgeeiQ66L42.
CleanExiMM_MAP3K10.
GenevestigatoriQ66L42.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ66L42. 1 interaction.
MINTiMINT-8414998.
STRINGi10090.ENSMUSP00000103978.

Structurei

3D structure databases

ProteinModelPortaliQ66L42.
SMRiQ66L42. Positions 17-78, 87-428.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 8166SH3
Add
BLAST
Domaini98 – 360263Protein kinase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni384 – 40522Leucine-zipper 1
Add
BLAST
Regioni419 – 44022Leucine-zipper 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi763 – 915153Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117425.
HOGENOMiHOG000060081.
HOVERGENiHBG067662.
OrthoDBiEOG7D85VN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR015785. MAP3K10.
IPR016231. MAPKKK9/10/11.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23257:SF370. PTHR23257:SF370. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000556. MAPKKK9_11. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66L42-1 [UniParc]FASTAAdd to Basket

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MEEEEGAAAR EWGATPAGPV WTAVFDYEAV GDEELTLRRG DRVQVLSQDC    50
AVSGDEGWWT GQLPSGRVGV FPSNYVAPAA PAAPSDLQLP QEIPFHELQL 100
EEIIGVGGFG KVYRAVWRGE EVAVKAARLD PERDPAVTAE QVRQEARLFG 150
ALQHPNIIAL RGACLSPPNL CLVMEYARGG ALSRVLAGRR VPPHVLVNWA 200
VQVARGMNYL HNDAPVPIIH RDLKSINILI LEAIENHNLA DTVLKITDFG 250
LAREWHKTTK MSAAGTYAWM APEVIRLSLF SKSSDVWSFG VLLWELLTGE 300
VPYREIDALA VAYGVAMNKL TLPIPSTCPE PFARLLEECW DPDPHGRPDF 350
GSILKQLEVI EQSALFQMPL ESFHSLQEDW KLEIQHMFDD LRTKEKELRS 400
REEELLRAAQ EQRFQEEQLR RREQELAERE MDIVERELHL LMSQLSQEKP 450
RVRKRKGNFK RSRLLKLREG SSHISLPSGF EHKITVQASP TLDKRKGSDG 500
ASPPASPSII PRLRAIRLTP MDCGGSSGSG TWSRSGPPKK EELVGGKKKG 550
RTWGPSSTLQ KERAGGEERL KALGEGSKQW SSSAPNLGKS PKHTPMAPGF 600
ASLNEMEEFA EADEGNNVPP SPYSTPSYLK VPLPAEPSPC VQAPWEPPAV 650
TPSRPGHGAR RRCDLALLSC ATLLSAVGLG ADVAEARAGD GEEQRRWLDS 700
LFFPRPGRFP RGLSPTGRPG GRREDTAPGL GLAPSATLVS LSSVSDCNST 750
RSLLRSDSDE AAPAAPSPPP SPLAPSPSTN PLVDVELESF KKDPRQSLTP 800
THVTAAHAVS RGHRRTPSDG ALRQREPLEL TNHGPRDPLD FPRLPDPQAL 850
FPTRRRPLEF PGRPTTLTFA PRPRPAASRP RLDPWKLVSF GRTLSISPPS 900
RPDTPESPGP PSVQPTLLDM DMEGQSQDNT VPLCGVYGSH 940
Length:940
Mass (Da):103,187
Last modified:February 20, 2007 - v2
Checksum:iBE27F39679DC63D0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3534FGSI → PTRP in AAH46514. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC074312 Genomic DNA. No translation available.
BC046514 mRNA. Translation: AAH46514.1.
BC078445 mRNA. Translation: AAH78445.1.
CCDSiCCDS39850.1.
RefSeqiNP_001277457.1. NM_001290528.1.
UniGeneiMm.389883.

Genome annotation databases

EnsembliENSMUST00000036453; ENSMUSP00000037725; ENSMUSG00000040390.
GeneIDi269881.
UCSCiuc012fgl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC074312 Genomic DNA. No translation available.
BC046514 mRNA. Translation: AAH46514.1 .
BC078445 mRNA. Translation: AAH78445.1 .
CCDSi CCDS39850.1.
RefSeqi NP_001277457.1. NM_001290528.1.
UniGenei Mm.389883.

3D structure databases

ProteinModelPortali Q66L42.
SMRi Q66L42. Positions 17-78, 87-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q66L42. 1 interaction.
MINTi MINT-8414998.
STRINGi 10090.ENSMUSP00000103978.

PTM databases

PhosphoSitei Q66L42.

Proteomic databases

PaxDbi Q66L42.
PRIDEi Q66L42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036453 ; ENSMUSP00000037725 ; ENSMUSG00000040390 .
GeneIDi 269881.
UCSCi uc012fgl.1. mouse.

Organism-specific databases

MGIi MGI:1346879. Map3k10.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117425.
HOGENOMi HOG000060081.
HOVERGENi HBG067662.
OrthoDBi EOG7D85VN.

Miscellaneous databases

PROi Q66L42.
SOURCEi Search...

Gene expression databases

Bgeei Q66L42.
CleanExi MM_MAP3K10.
Genevestigatori Q66L42.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR015785. MAP3K10.
IPR016231. MAPKKK9/10/11.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR23257:SF370. PTHR23257:SF370. 1 hit.
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PIRSFi PIRSF000556. MAPKKK9_11. 1 hit.
PRINTSi PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-940.
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiM3K10_MOUSE
AccessioniPrimary (citable) accession number: Q66L42
Secondary accession number(s): Q80UW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi