Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5-methylcytosine rRNA methyltransferase NSUN4

Gene

nsun4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in mitochondrial ribosome large subunit biogenesis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei259S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei277S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei332NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
5-methylcytosine rRNA methyltransferase NSUN4 (EC:2.1.1.-)
Alternative name(s):
NOL1/NOP2/Sun domain family member 4
Gene namesi
Name:nsun4
ORF Names:TGas136a10.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-948188. nsun4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892371 – 4065-methylcytosine rRNA methyltransferase NSUN4Add BLAST406

Proteomic databases

PaxDbiQ66KI9.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000052934.

Structurei

3D structure databases

ProteinModelPortaliQ66KI9.
SMRiQ66KI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 209S-adenosyl-L-methionine bindingPROSITE-ProRule annotation7

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2198. Eukaryota.
COG0144. LUCA.
HOGENOMiHOG000017426.
HOVERGENiHBG106892.
InParanoidiQ66KI9.
KOiK21970.

Family and domain databases

InterProiView protein in InterPro
IPR001678. MeTrfase_RsmB/NOP2.
IPR023267. RCMT.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51686. SAM_MT_RSMB_NOP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66KI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAACRGFLLR RINDSCLTFR RHKFKKKWAT TLPKIPCSRL ALQYFDMNYS
60 70 80 90 100
MQFGDLWPSI RISLLTEQKY GALVNNFSHK ETVLKNLSAF NAKDFISEAQ
110 120 130 140 150
HVISLLQIQN NLDTSEKMTS GEASLNLVGQ KNNAEKTQAT NLLSSLSNTK
160 170 180 190 200
LTCFKFSRGD ISRFPQSRSD SFGLLEYYLM DAASLLPVLA LDVQHGHSVL
210 220 230 240 250
DLCAAPGGKT LALLQTENCQ YLAANDLSTS RSSRLHRVLR SYVPRAQRTE
260 270 280 290 300
HKVCITSQDG RLWGDAEANT YDRVLVDVPC TTDRHSLLEE ENNIFHRIRT
310 320 330 340 350
KQRQMLPLLQ AELLVAGLRA VRPGGEVVYS TCSLSQLQNE CVVERAVELA
360 370 380 390 400
ASDHGVHVKP QDLSCFREVF KNTFNFFQGC RVGELVLPHL TANFGPMFFC

KLLRIE
Length:406
Mass (Da):45,829
Last modified:October 11, 2004 - v1
Checksum:iAA3D7A53F294A2BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848182 mRNA. Translation: CAJ83825.1.
BC080376 mRNA. Translation: AAH80376.1.
RefSeqiNP_001007930.1. NM_001007929.1.
UniGeneiStr.15258.

Genome annotation databases

GeneIDi100493736.
KEGGixtr:100493736.

Similar proteinsi

Entry informationi

Entry nameiNSUN4_XENTR
AccessioniPrimary (citable) accession number: Q66KI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: October 25, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome