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Protein

Protein APCDD1

Gene

apcdd1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of Wnt signaling pathway Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein APCDD1
Alternative name(s):
Adenomatosis polyposis coli down-regulated 1 protein homolog
Protein primglo
Short name:
xPgo
Gene namesi
Name:apcdd1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5762142. apcdd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 488460ExtracellularSequence analysisAdd
BLAST
Transmembranei489 – 50921Sequence analysisAdd
BLAST
Topological domaini510 – 5156CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 515487Protein APCDD1PRO_0000395840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the APCDD1 family.Curated

Keywords - Domaini

Signal, Transmembrane

Phylogenomic databases

HOVERGENiHBG060356.

Family and domain databases

InterProiIPR029405. APCDD1.
[Graphical view]
PfamiPF14921. APCDDC. 2 hits.
[Graphical view]
SMARTiSM01352. APCDDC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66KI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIPCFYSSL ISCLFSIITL VDVGQSSALT LSDSRLHPQS LEKSPWREFQ
60 70 80 90 100
CQHMLKHLHN GARVTVQMPP NIEGHWVSMG CEVRSGPEFI TRSYRFYNNN
110 120 130 140 150
TFKAYQHYYG NNHCTIPTYT LVIRGKIRLR QASWIIRGGT EADYQLHNVQ
160 170 180 190 200
IIPHSETVAE KLTWLVNHTC AGFVPGDMPW EPGISYDLWR EEGGFKCTKA
210 220 230 240 250
LNFAMHELQL IRVEKQYMHH NLDHLVEELF LGDIHTDPSQ RMYYRPSSYQ
260 270 280 290 300
PPLQNAKNHN QNCVACRIIL RSDEHHPPIL PAKADLPVGL NGEWVSQRCE
310 320 330 340 350
VRPEVLFLTR HFIFNDNNHT WEGFYYHYSD PICKHPSFTI YAKGRYSRGV
360 370 380 390 400
YSSKVMGGTE FVFKVNHMKV TPMDFATASL LNVFNGDECG AEGSWKVGVE
410 420 430 440 450
QDVTHTNGCV ALGIKLPHTE YELFRMEQDN RGRYLLYNGQ RPSDGSSPAR
460 470 480 490 500
PEKRATSYQV PLVQCTSVSL NPEGAHDGQH KSQSRNSAAG HIFLYLFSNL
510
FLLFICTLLH LEILS
Length:515
Mass (Da):58,943
Last modified:October 11, 2004 - v1
Checksum:iAB0D178A5EB980B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001N → D in BAE02564 (Ref. 1) Curated
Sequence conflicti177 – 1771D → H in BAE02564 (Ref. 1) Curated
Sequence conflicti215 – 2151K → E in BAE02564 (Ref. 1) Curated
Sequence conflicti462 – 4621L → V in BAE02564 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196973 mRNA. Translation: BAE02564.1.
BC080377 mRNA. Translation: AAH80377.1.
RefSeqiNP_001087578.1. NM_001094109.1.
UniGeneiXl.8648.

Genome annotation databases

GeneIDi447402.
KEGGixla:447402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196973 mRNA. Translation: BAE02564.1.
BC080377 mRNA. Translation: AAH80377.1.
RefSeqiNP_001087578.1. NM_001094109.1.
UniGeneiXl.8648.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi447402.
KEGGixla:447402.

Organism-specific databases

CTDi147495.
XenbaseiXB-GENE-5762142. apcdd1.

Phylogenomic databases

HOVERGENiHBG060356.

Family and domain databases

InterProiIPR029405. APCDD1.
[Graphical view]
PfamiPF14921. APCDDC. 2 hits.
[Graphical view]
SMARTiSM01352. APCDDC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPCD1_XENLA
AccessioniPrimary (citable) accession number: Q66KI8
Secondary accession number(s): Q4R1K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 11, 2004
Last modified: May 11, 2016
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.