Q66KG5 (GMPAB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase alpha-B
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase A-B
GTP-mannose-1-phosphate guanylyltransferase apha-B

Gene names

Name:

gmppa-b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	Mannose-1-phosphate guanyltransferase alpha-B		PRO_0000327879

Sequences

	Sequence		Length	Mass (Da)
	Q66KG5 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 5CA6C5D4872C1828	FASTA	426	46,884
	10 20 30 40 50 60 MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMVQHH IEACSKVPNL KEILLIGFYQ 70 80 90 100 110 120 PNEALSSFLL KAQQEFKVAI RYLQEYSALG TGGGIYHFRD QILSGGPQAF FVMNADVCSE 130 140 150 160 170 180 FPLVPMLDFH KQHGGSQSYV ILGTTANRTQ SLNYGCIVSN GDTQEVLHYV EKPGTFVSDI 190 200 210 220 230 240 INCGIYLFSP SIFQHIAEVF QRNQLELQLF SCISEENSSW QRTEVIRLEQ DVFTTLAGHG 250 260 270 280 290 300 KLYVYKTEGC WSQIKSAGSA IYASRLYLSQ YSTTHPERLA STKEGGPTIR GNVYIHPTAN 310 320 330 340 350 360 VDPSAVLGPN VSVGMGVTVG AGVRIRESII LHGAVLQDHS CVLNTIVGWD SMVGRWARVE 370 380 390 400 410 420 GTPSDPNPND PYSKIDSETL FREGKLTPSI TILGCNVSIP AEVVILNSIV LPHKELSRSF KNQIIL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC080405 mRNA. Translation: AAH80405.1.
RefSeq	NP_001087596.1. NM_001094127.1.
UniGene	Xl.48629.
3D structure databases
ProteinModelPortal	Q66KG5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	447420.
KEGG	xla:447420.
Organism-specific databases
CTD	447420.
Xenbase	XB-GENE-984245. gmppa.
Phylogenomic databases
HOVERGEN	HBG059531.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPAB_XENLA

Accession

Primary (citable) accession number: Q66KG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	October 11, 2004
Last modified:	November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program