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Q66KB0

- UBE2Z_XENTR

UniProt

Q66KB0 - UBE2Z_XENTR

Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

ube2z

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in apoptosis regulation By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei147 – 1471Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Apoptosis, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Z (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein Z
    Ubiquitin-protein ligase Z
    Gene namesi
    Name:ube2z
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-990986. ube2z.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Ubiquitin-conjugating enzyme E2 ZPRO_0000280520Add
    BLAST

    Proteomic databases

    PRIDEiQ66KB0.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000049362.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66KB0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    HOGENOMiHOG000233451.
    HOVERGENiHBG083204.
    InParanoidiQ66KB0.
    KOiK10585.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q66KB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAESPAAEAI ILPGAAAGGG VLPHLSGLQA PGTSPLTTSS VWDPTASADW    50
    DNERASNQCV LRIKRDIMSI YKEPPPGMFV VPDPHDMTKI HALITGPFDT 100
    PYEGGFFLFL FRCPPDYPIH PPRVKLMTTG NNTVRFNPNF YRNGKVCLSI 150
    LGTWTGPAWS PAQSLSSVLI SIQSLMTENP YHNEPGFEQE RHSGDSKNYN 200
    ECIRHETIRV AVCEMLEGKC QCPDALRSVM EKSFMEYYDF YEAVCKDRFH 250
    LQGQNMQDPF GEKRGHFDYQ SLLSRLQTIH QRVREKHRKE TVDIDSDSSS 300
    SETETDTQGS SNP 313
    Length:313
    Mass (Da):35,077
    Last modified:March 20, 2007 - v2
    Checksum:iDB57158992D65819
    GO

    Sequence cautioni

    The sequence AAH80480.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080480 mRNA. Translation: AAH80480.1. Different initiation.
    RefSeqiNP_001007969.2. NM_001007968.2.
    UniGeneiStr.10246.

    Genome annotation databases

    GeneIDi493338.
    KEGGixtr:493338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC080480 mRNA. Translation: AAH80480.1 . Different initiation.
    RefSeqi NP_001007969.2. NM_001007968.2.
    UniGenei Str.10246.

    3D structure databases

    ProteinModelPortali Q66KB0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000049362.

    Proteomic databases

    PRIDEi Q66KB0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 493338.
    KEGGi xtr:493338.

    Organism-specific databases

    CTDi 65264.
    Xenbasei XB-GENE-990986. ube2z.

    Phylogenomic databases

    eggNOGi COG5078.
    HOGENOMi HOG000233451.
    HOVERGENi HBG083204.
    InParanoidi Q66KB0.
    KOi K10585.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiUBE2Z_XENTR
    AccessioniPrimary (citable) accession number: Q66KB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3