ID   Q66K75_HUMAN            Unreviewed;       498 AA.
AC   Q66K75;
DT   11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=MYH11 protein {ECO:0000313|EMBL:AAH80545.1};
DE   Flags: Fragment;
GN   Name=MYH11 {ECO:0000313|EMBL:AAH80545.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH80545.1};
RN   [1] {ECO:0000313|EMBL:AAH80545.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lymph {ECO:0000313|EMBL:AAH80545.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC080545; AAH80545.1; -; mRNA.
DR   AlphaFoldDB; Q66K75; -.
DR   IntAct; Q66K75; 2.
DR   PeptideAtlas; Q66K75; -.
DR   ChiTaRS; MYH11; human.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR   Gene3D; 6.10.250.2420; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46349:SF7; MYOSIN_TAIL_1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01576; Myosin_tail_1; 1.
DR   SUPFAM; SSF90257; Myosin rod fragments; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054}.
FT   DOMAIN          1..454
FT                   /note="Myosin tail"
FT                   /evidence="ECO:0000259|Pfam:PF01576"
FT   REGION          103..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..243
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..313
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        392..441
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..498
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH80545.1"
SQ   SEQUENCE   498 AA;  57373 MW;  98919827DAB8CE07 CRC64;
     EAEAREKETK ALSLARALEE ALEAKEELER TNKMLKAEME DLVSSKDDVG KNVHELEKSK
     RALETQMEEM KTQLEELEDE LQATEDAKLR LEVNMQALKG QFERDLQARD EQNEEKRRQL
     QRQLHEYETE LEDERKQRAL AAAAKKKLEG DLKDLELQAD SAIKGREEAI KQLRKLQAQM
     KDFQRELEDA RASRDEIFAT AKENEKKAKS LEADLMQLQE DLAAAERARK QADLEKEELA
     EELASSLSGR NALQDEKRRL EARIAQLEEE LEEEQGNMEA MSDRVRKATQ QAEQLSNELA
     TERSTAQKNE SARQQLERQN KELRSKLHEM EGAVKSKFKS TIAALEAKIA QLEEQVEQEA
     REKQAATKSL KQKDKKLKEI LLQVEDERKM AEQYKEQAEK GNARVKQLKR QLEEAEEESQ
     RINANRRKLQ RELDEATESN EAMGREVNAL KSKLRRGNET SFVPSRRSGG RRVIENADGS
     EEETDTRDAD FNGTKASE
//