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Protein

Transmembrane protein 198

Gene

TMEM198

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 198
Gene namesi
Name:TMEM198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33704. TMEM198.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406347.

Polymorphism and mutation databases

BioMutaiTMEM198.
DMDMi74736317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Transmembrane protein 198PRO_0000326030Add
BLAST

Proteomic databases

PaxDbiQ66K66.
PRIDEiQ66K66.

PTM databases

PhosphoSiteiQ66K66.

Expressioni

Gene expression databases

BgeeiQ66K66.
CleanExiHS_TMEM198.
ExpressionAtlasiQ66K66. baseline and differential.
GenevisibleiQ66K66. HS.

Organism-specific databases

HPAiHPA056598.

Interactioni

Subunit structurei

Interacts with LRP6.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000343507.

Structurei

3D structure databases

ProteinModelPortaliQ66K66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 233170Leu-richAdd
BLAST
Compositional biasi252 – 30150Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM198 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGI3. Eukaryota.
ENOG4110N65. LUCA.
GeneTreeiENSGT00390000016940.
HOGENOMiHOG000036051.
HOVERGENiHBG060418.
InParanoidiQ66K66.
OMAiIAAWPVT.
OrthoDBiEOG74N5HQ.
PhylomeDBiQ66K66.
TreeFamiTF323324.

Family and domain databases

InterProiIPR025256. DUF4203.
[Graphical view]
PfamiPF13886. DUF4203. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66K66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGTVATLRF QLLPPEPDDA FWGAPCEQPL ERRYQALPAL VCIMCCLFGV
60 70 80 90 100
VYCFFGYRCF KAVLFLTGLL FGSVVIFLLC YRERVLETQL SAGASAGIAL
110 120 130 140 150
GIGLLCGLVA MLVRSVGLFL VGLLLGLLLA AAALLGSAPY YQPGSVWGPL
160 170 180 190 200
GLLLGGGLLC ALLTLRWPRP LTTLATAVTG AALIATAADY FAELLLLGRY
210 220 230 240 250
VVERLRAAPV PPLCWRSWAL LALWPLLSLM GVLVQWRVTA EGDSHTEVVI
260 270 280 290 300
SRQRRRVQLM RIRQQEDRKE KRRKKRPPRA PLRGPRAPPR PGPPDPAYRR
310 320 330 340 350
RPVPIKRFNG DVLSPSYIQS FRDRQTGSSL SSFMASPTDA DYEYGSRGPL
360
TACSGPPVRV
Length:360
Mass (Da):39,475
Last modified:October 11, 2004 - v1
Checksum:i19094DCD0EE8AEEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471063 Genomic DNA. Translation: EAW70771.1.
BC080573 mRNA. Translation: AAH80573.1.
CCDSiCCDS33385.1.
RefSeqiNP_001005209.1. NM_001005209.2.
NP_001290027.1. NM_001303098.1.
UniGeneiHs.446664.

Genome annotation databases

EnsembliENST00000344458; ENSP00000343507; ENSG00000188760.
ENST00000373883; ENSP00000362990; ENSG00000188760.
GeneIDi130612.
KEGGihsa:130612.
UCSCiuc002vme.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471063 Genomic DNA. Translation: EAW70771.1.
BC080573 mRNA. Translation: AAH80573.1.
CCDSiCCDS33385.1.
RefSeqiNP_001005209.1. NM_001005209.2.
NP_001290027.1. NM_001303098.1.
UniGeneiHs.446664.

3D structure databases

ProteinModelPortaliQ66K66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000343507.

PTM databases

PhosphoSiteiQ66K66.

Polymorphism and mutation databases

BioMutaiTMEM198.
DMDMi74736317.

Proteomic databases

PaxDbiQ66K66.
PRIDEiQ66K66.

Protocols and materials databases

DNASUi130612.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344458; ENSP00000343507; ENSG00000188760.
ENST00000373883; ENSP00000362990; ENSG00000188760.
GeneIDi130612.
KEGGihsa:130612.
UCSCiuc002vme.5. human.

Organism-specific databases

CTDi130612.
GeneCardsiTMEM198.
HGNCiHGNC:33704. TMEM198.
HPAiHPA056598.
neXtProtiNX_Q66K66.
PharmGKBiPA162406347.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGI3. Eukaryota.
ENOG4110N65. LUCA.
GeneTreeiENSGT00390000016940.
HOGENOMiHOG000036051.
HOVERGENiHBG060418.
InParanoidiQ66K66.
OMAiIAAWPVT.
OrthoDBiEOG74N5HQ.
PhylomeDBiQ66K66.
TreeFamiTF323324.

Miscellaneous databases

GenomeRNAii130612.
NextBioi82787.
PROiQ66K66.

Gene expression databases

BgeeiQ66K66.
CleanExiHS_TMEM198.
ExpressionAtlasiQ66K66. baseline and differential.
GenevisibleiQ66K66. HS.

Family and domain databases

InterProiIPR025256. DUF4203.
[Graphical view]
PfamiPF13886. DUF4203. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. "Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation."
    Liang J., Fu Y., Cruciat C.M., Jia S., Wang Y., Tong Z., Tao Q., Ingelfinger D., Boutros M., Meng A., Niehrs C., Wu W.
    Mol. Cell. Biol. 31:2577-2590(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LRP6.

Entry informationi

Entry nameiTM198_HUMAN
AccessioniPrimary (citable) accession number: Q66K66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2004
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.