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Protein

DDB1- and CUL4-associated factor 15

Gene

DCAF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 15
Gene namesi
Name:DCAF15
Synonyms:C19orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25095. DCAF15.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165393390.

Polymorphism and mutation databases

BioMutaiDCAF15.
DMDMi74736316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600DDB1- and CUL4-associated factor 15PRO_0000314485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501PhosphoserineCombined sources
Modified residuei310 – 3101PhosphoserineCombined sources
Modified residuei314 – 3141PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ66K64.
MaxQBiQ66K64.
PaxDbiQ66K64.
PeptideAtlasiQ66K64.
PRIDEiQ66K64.

PTM databases

iPTMnetiQ66K64.
PhosphoSiteiQ66K64.

Expressioni

Gene expression databases

BgeeiENSG00000132017.
ExpressionAtlasiQ66K64. baseline and differential.
GenevisibleiQ66K64. HS.

Interactioni

Subunit structurei

Interacts with DDB1 and CUL4A.1 Publication

Protein-protein interaction databases

BioGridi124705. 21 interactions.
IntActiQ66K64. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ66K64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFED. Eukaryota.
ENOG410ZN1V. LUCA.
GeneTreeiENSGT00390000011987.
HOGENOMiHOG000112173.
HOVERGENiHBG095849.
InParanoidiQ66K64.
KOiK11791.
OMAiDPSAQCL.
OrthoDBiEOG091G03E7.
PhylomeDBiQ66K64.
TreeFamiTF329680.

Family and domain databases

InterProiIPR032734. DCAF15_WD40.
[Graphical view]
PfamiPF14939. DCAF15_WD40. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66K64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSSKSERN SGAGSGGGGP GGAGGKRAAG RRREHVLKQL ERVKISGQLS
60 70 80 90 100
PRLFRKLPPR VCVSLKNIVD EDFLYAGHIF LGFSKCGRYV LSYTSSSGDD
110 120 130 140 150
DFSFYIYHLY WWEFNVHSKL KLVRQVRLFQ DEEIYSDLYL TVCEWPSDAS
160 170 180 190 200
KVIVFGFNTR SANGMLMNMM MMSDENHRDI YVSTVAVPPP GRCAACQDAS
210 220 230 240 250
RAHPGDPNAQ CLRHGFMLHT KYQVVYPFPT FQPAFQLKKD QVVLLNTSYS
260 270 280 290 300
LVACAVSVHS AGDRSFCQIL YDHSTCPLAP ASPPEPQSPE LPPALPSFCP
310 320 330 340 350
EAAPARSSGS PEPSPAIAKA KEFVADIFRR AKEAKGGVPE EARPALCPGP
360 370 380 390 400
SGSRCRAHSE PLALCGETAP RDSPPASEAP ASEPGYVNYT KLYYVLESGE
410 420 430 440 450
GTEPEDELED DKISLPFVVT DLRGRNLRPM RERTAVQGQY LTVEQLTLDF
460 470 480 490 500
EYVINEVIRH DATWGHQFCS FSDYDIVILE VCPETNQVLI NIGLLLLAFP
510 520 530 540 550
SPTEEGQLRP KTYHTSLKVA WDLNTGIFET VSVGDLTEVK GQTSGSVWSS
560 570 580 590 600
YRKSCVDMVM KWLVPESSGR YVNRMTNEAL HKGCSLKVLA DSERYTWIVL
Length:600
Mass (Da):66,463
Last modified:October 11, 2004 - v1
Checksum:i091BB2D0AADF3E6F
GO

Sequence cautioni

The sequence AAH13280 differs from that shown. Reason: Frameshift at position 89. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093072 mRNA. Translation: BAG52648.1.
CH471106 Genomic DNA. Translation: EAW84386.1.
BC002926 mRNA. Translation: AAH02926.2.
BC013280 mRNA. Translation: AAH13280.2. Frameshift.
BC080575 mRNA. Translation: AAH80575.1.
CCDSiCCDS32926.1.
RefSeqiNP_612362.2. NM_138353.2.
UniGeneiHs.443636.

Genome annotation databases

EnsembliENST00000254337; ENSP00000254337; ENSG00000132017.
GeneIDi90379.
KEGGihsa:90379.
UCSCiuc002mxt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093072 mRNA. Translation: BAG52648.1.
CH471106 Genomic DNA. Translation: EAW84386.1.
BC002926 mRNA. Translation: AAH02926.2.
BC013280 mRNA. Translation: AAH13280.2. Frameshift.
BC080575 mRNA. Translation: AAH80575.1.
CCDSiCCDS32926.1.
RefSeqiNP_612362.2. NM_138353.2.
UniGeneiHs.443636.

3D structure databases

ProteinModelPortaliQ66K64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124705. 21 interactions.
IntActiQ66K64. 1 interaction.

PTM databases

iPTMnetiQ66K64.
PhosphoSiteiQ66K64.

Polymorphism and mutation databases

BioMutaiDCAF15.
DMDMi74736316.

Proteomic databases

EPDiQ66K64.
MaxQBiQ66K64.
PaxDbiQ66K64.
PeptideAtlasiQ66K64.
PRIDEiQ66K64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254337; ENSP00000254337; ENSG00000132017.
GeneIDi90379.
KEGGihsa:90379.
UCSCiuc002mxt.4. human.

Organism-specific databases

CTDi90379.
GeneCardsiDCAF15.
H-InvDBHIX0014830.
HGNCiHGNC:25095. DCAF15.
neXtProtiNX_Q66K64.
PharmGKBiPA165393390.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFED. Eukaryota.
ENOG410ZN1V. LUCA.
GeneTreeiENSGT00390000011987.
HOGENOMiHOG000112173.
HOVERGENiHBG095849.
InParanoidiQ66K64.
KOiK11791.
OMAiDPSAQCL.
OrthoDBiEOG091G03E7.
PhylomeDBiQ66K64.
TreeFamiTF329680.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

GenomeRNAii90379.
PROiQ66K64.

Gene expression databases

BgeeiENSG00000132017.
ExpressionAtlasiQ66K64. baseline and differential.
GenevisibleiQ66K64. HS.

Family and domain databases

InterProiIPR032734. DCAF15_WD40.
[Graphical view]
PfamiPF14939. DCAF15_WD40. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCA15_HUMAN
AccessioniPrimary (citable) accession number: Q66K64
Secondary accession number(s): B3KS86, Q96DW0, Q9BU31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.