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Protein

Zinc finger protein 385C

Gene

ZNF385C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 10731Matrin-type 1Add
BLAST
Zinc fingeri225 – 25935Matrin-type 2Add
BLAST
Zinc fingeri290 – 32031Matrin-type 3Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 385C
Gene namesi
Name:ZNF385C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:33722. ZNF385C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi172044654.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Zinc finger protein 385CPRO_0000319941Add
BLAST

Proteomic databases

PaxDbiQ66K41.
PRIDEiQ66K41.

PTM databases

iPTMnetiQ66K41.
PhosphoSiteiQ66K41.

Expressioni

Gene expression databases

CleanExiHS_ZNF385C.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BOLLQ8N9W63EBI-10219231,EBI-998198
HNRNPKP619783EBI-10219231,EBI-304185
HNRPKQ6IBN13EBI-10219231,EBI-3440248
PSMA3P257883EBI-10219231,EBI-348380
RBMY1JQ154153EBI-10219231,EBI-8642021
RBPMSQ930623EBI-10219231,EBI-740322
THAP1Q9NVV93EBI-10219231,EBI-741515

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ66K41. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ66K41.
SMRiQ66K41. Positions 287-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 20173Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 matrin-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 10731Matrin-type 1Add
BLAST
Zinc fingeri225 – 25935Matrin-type 2Add
BLAST
Zinc fingeri290 – 32031Matrin-type 3Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGA9. Eukaryota.
ENOG410ZUZY. LUCA.
HOGENOMiHOG000231865.
HOVERGENiHBG054524.
InParanoidiQ66K41.
PhylomeDBiQ66K41.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q66K41-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAGPASGAP SPLLASLPLP TRPLQPPLDF KHLLAFHFNG AAPLSLFPNF
60 70 80 90 100
STMDPVQKAV ISHTFGVPSP LKKKLFISCN ICHLRFNSAN QAEAHYKGHK
110 120 130 140 150
HARKLKAVEA AKSKQRPHTQ AQDGAVVSPI PTLASGAPGE PQSKVPAAPP
160 170 180 190 200
LGPPLQPPPT PDPTCREPAH SELLDAASSS SSSSCPPCSP EPGREAPGPE
210 220 230 240 250
PAAAAVGSSM SGEGRSEKGH LYCPTCKVTV NSASQLQAHN TGAKHRWMME
260 270 280 290 300
GQRGAPRRSR GRPVSRGGAG HKAKRVTGGR GGRQGPSPAF HCALCQLQVN
310 320 330 340 350
SETQLKQHMS SRRHKDRLAG KTPKPSSQHS KLQKHAALAV SILKSKLALQ
360 370 380 390 400
KQLTKTLAAR FLPSPLPTAA TAICALPGPL ALRPAPTAAT TLFPAPILGP
410 420
ALFRTPAGAV RPATGPIVLA PY
Length:422
Mass (Da):44,107
Last modified:February 26, 2008 - v2
Checksum:i95227EEE6E8709FA
GO
Isoform 2 (identifier: Q66K41-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.

Note: No experimental confirmation available.
Show »
Length:174
Mass (Da):18,242
Checksum:i6C71BB717FD1D50D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 248248Missing in isoform 2. 1 PublicationVSP_031546Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105024 Genomic DNA. No translation available.
BC080613 mRNA. Translation: AAH80613.1.
UniGeneiHs.443140.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105024 Genomic DNA. No translation available.
BC080613 mRNA. Translation: AAH80613.1.
UniGeneiHs.443140.

3D structure databases

ProteinModelPortaliQ66K41.
SMRiQ66K41. Positions 287-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ66K41. 7 interactions.

PTM databases

iPTMnetiQ66K41.
PhosphoSiteiQ66K41.

Polymorphism and mutation databases

DMDMi172044654.

Proteomic databases

PaxDbiQ66K41.
PRIDEiQ66K41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiZNF385C.
HGNCiHGNC:33722. ZNF385C.
neXtProtiNX_Q66K41.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGA9. Eukaryota.
ENOG410ZUZY. LUCA.
HOGENOMiHOG000231865.
HOVERGENiHBG054524.
InParanoidiQ66K41.
PhylomeDBiQ66K41.

Miscellaneous databases

ChiTaRSiZNF385C. human.
PROiQ66K41.

Gene expression databases

CleanExiHS_ZNF385C.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ385C_HUMAN
AccessioniPrimary (citable) accession number: Q66K41
Secondary accession number(s): Q4G0J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 13, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.