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Q66K08

- CILP1_MOUSE

UniProt

Q66K08 - CILP1_MOUSE

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Protein
Cartilage intermediate layer protein 1
Gene
Cilp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage By similarity.

GO - Biological processi

  1. negative regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage intermediate layer protein 1
Short name:
CILP-1
Cleaved into the following 2 chains:
Gene namesi
Name:Cilp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2444507. Cilp.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 11841163Cartilage intermediate layer protein 1
PRO_0000014674Add
BLAST
Chaini22 – ?724703Cartilage intermediate layer protein 1 C1
PRO_0000014675Add
BLAST
Chaini?725 – 1184460Cartilage intermediate layer protein 1 C2
PRO_0000014676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 195 By similarity
Disulfide bondi165 ↔ 200 By similarity
Disulfide bondi177 ↔ 185 By similarity
Disulfide bondi330 ↔ 376 By similarity
Glycosylationi346 – 3461N-linked (GlcNAc...) By similarity
Glycosylationi420 – 4201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi550 – 5501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi631 – 6311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1000 – 10001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1056 – 10561N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ66K08.
PRIDEiQ66K08.

PTM databases

PhosphoSiteiQ66K08.

Expressioni

Gene expression databases

ArrayExpressiQ66K08.
BgeeiQ66K08.
GenevestigatoriQ66K08.

Interactioni

Subunit structurei

Monomer. Interacts with TGFB1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ66K08.
SMRiQ66K08. Positions 269-394.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 20152TSP type-1
Add
BLAST
Domaini309 – 39385Ig-like C2-type
Add
BLAST

Sequence similaritiesi

Contains 1 TSP type-1 domain.

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG38857.
GeneTreeiENSGT00390000008152.
HOGENOMiHOG000111676.
HOVERGENiHBG081175.
InParanoidiQ66K08.
OrthoDBiEOG780RKM.
PhylomeDBiQ66K08.
TreeFamiTF330132.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR000884. Thrombospondin_1_rpt.
IPR025155. WxxW_domain.
[Graphical view]
PfamiPF13330. Mucin2_WxxW. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00209. TSP1. 1 hit.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66K08-1 [UniParc]FASTAAdd to Basket

« Hide

MAAIKTWVFS FLVLEVTTVL GRQTMLAQSV RRVQPVKRTP KTLAKPADSQ     50
ESPGEWTTWF NIDHPGGQGD YERLDAIRFY YGERVCARPL RLEARTTDWM 100
PAGSTGQVVH GSPREGFWCL NREQRPGQNC SNYTVRFLCP PGSLRGDAEH 150
IWSSWSPWSK CSAACGHTGV QTRTRTCLAQ TVSLCSEATE EGQLCMSQAC 200
TACDLTCPMG QVNADCDACM CQDFMLHGAI SLPGGGPAPG AAVYLLAKAP 250
KMLTRTDSSG RFRVPGLCPD GKTILKITKT KFAPIMITMP KTSLKSATIN 300
AEFVRAETPY IVMNPEMKAR RAGQSVSLCC KATGKPSPDK YFWYHNNTLL 350
DPSLYKHESK LVLRNLQQDQ AGEYFCKAQS DAGAVKSKVT QLTVIAHDET 400
PCNPTPESYL IRLPHDCFQN ASNSFYYDVG RCPIKTCAGQ QDNGIRCRDA 450
VENCCGISRT EEREIQCSGY TLPTKVAVEC SCQRCAETRS IVRGRVTATD 500
NGEPMRFGHV YMGNNRVSMT GYKGTFTLHI PQDTERLVLT FVDRLQKFVN 550
TTKVLPFNKK GSAVFHEIKM LRQKEPITLE AMETNIIPLG EVIGEDPVAE 600
LEIPSKSFYR QNGEPFTGKV KASVTFLDPR NISTATAAQS DLNFINDEGD 650
TFPLRTYGMF SVDFRDEATS ESLNAGKVKV HLDSTQVKMP EHVPAMKLWS 700
LNPDTGLWEE EGDFKFESQR RNKREERTFL VGNMEIRERR LFNLDVPESR 750
RCFIKVRTYR SERFLPSEQI QGVVVSVINL EPRTGFSSNP RAWGRFDSVI 800
TGPNGACLPA FCDDQSPDAY SVYVLASLSG EELEAVESSP KFNPNAIGVP 850
QPYLNKLKYR RTDHEDPRVK KTAFQISMAK PRPNSAEESN GPIYAFENLR 900
ACEEAPPSAA HFRFYQIEGD RYDYNTVPFN EDDPMSWTED YLAWWPKPME 950
FRACYIKVKI VGPLEVNVRS RNMGGTHRQT VGKLYGIRDV KSTRDRDQPN 1000
VSSACLEFKC SGMLYDQDRV DRTLVKVIPQ GSCHRASVNS MLHEYLVNHL 1050
PLAVNNDTSE YTMLAPLDPL GHNYGIYTVT DQDPRTAKEI ALGRCFDGTS 1100
DGSSRIMKSN VGVALTFNCA ERQVGRQSAF QYLQSTPARS PATGTVQGRV 1150
PAMRQQRASR GGLRRRGSMA PLRFSGVAQQ PLSN 1184
Length:1,184
Mass (Da):132,334
Last modified:October 11, 2004 - v1
Checksum:iC83B97AC0D0DC9D3
GO

Sequence cautioni

The sequence BAC38252.1 differs from that shown. Reason: Frameshift at position 1170.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti499 – 4991T → A1 Publication
Sequence conflicti499 – 4991T → A1 Publication
Sequence conflicti734 – 7341M → L in AAM92572. 1 Publication
Sequence conflicti1155 – 11551Q → E in AAM92572. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK081544 mRNA. Translation: BAC38252.1. Frameshift.
BC080666 mRNA. Translation: AAH80666.1.
AY116589 Genomic DNA. Translation: AAM92571.1.
AY116591, AY116590 Genomic DNA. Translation: AAM92572.1.
RefSeqiNP_775561.1. NM_173385.2.
UniGeneiMm.138455.

Genome annotation databases

EnsembliENSMUST00000048762; ENSMUSP00000036631; ENSMUSG00000042254.
GeneIDi214425.
KEGGimmu:214425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK081544 mRNA. Translation: BAC38252.1 . Frameshift.
BC080666 mRNA. Translation: AAH80666.1 .
AY116589 Genomic DNA. Translation: AAM92571.1 .
AY116591 , AY116590 Genomic DNA. Translation: AAM92572.1 .
RefSeqi NP_775561.1. NM_173385.2.
UniGenei Mm.138455.

3D structure databases

ProteinModelPortali Q66K08.
SMRi Q66K08. Positions 269-394.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q66K08.

Proteomic databases

PaxDbi Q66K08.
PRIDEi Q66K08.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048762 ; ENSMUSP00000036631 ; ENSMUSG00000042254 .
GeneIDi 214425.
KEGGi mmu:214425.

Organism-specific databases

CTDi 8483.
MGIi MGI:2444507. Cilp.

Phylogenomic databases

eggNOGi NOG38857.
GeneTreei ENSGT00390000008152.
HOGENOMi HOG000111676.
HOVERGENi HBG081175.
InParanoidi Q66K08.
OrthoDBi EOG780RKM.
PhylomeDBi Q66K08.
TreeFami TF330132.

Miscellaneous databases

NextBioi 374308.
PROi Q66K08.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q66K08.
Bgeei Q66K08.
Genevestigatori Q66K08.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR000884. Thrombospondin_1_rpt.
IPR025155. WxxW_domain.
[Graphical view ]
Pfami PF13330. Mucin2_WxxW. 1 hit.
PF00090. TSP_1. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 1 hit.
SM00209. TSP1. 1 hit.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary tumor.
  3. "The mouse Cilp gene."
    Lorenzo P., Heinegaard D.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-51 AND 344-1184.
    Strain: 129/SvJ.

Entry informationi

Entry nameiCILP1_MOUSE
AccessioniPrimary (citable) accession number: Q66K08
Secondary accession number(s): Q7TSS0, Q7TSS1, Q8BV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi