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Protein

Rho guanine nucleotide exchange factor 39

Gene

Arhgef39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 39
Gene namesi
Name:Arhgef39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3036286. Arhgef39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Rho guanine nucleotide exchange factor 39PRO_0000291865Add
BLAST

Proteomic databases

EPDiQ66JY6.
PaxDbiQ66JY6.
PRIDEiQ66JY6.

PTM databases

iPTMnetiQ66JY6.
PhosphoSiteiQ66JY6.

Expressioni

Gene expression databases

BgeeiQ66JY6.
CleanExiMM_E130306D19RIK.
ExpressionAtlasiQ66JY6. baseline and differential.
GenevisibleiQ66JY6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ66JY6. 1 interaction.
STRINGi10090.ENSMUSP00000055293.

Structurei

3D structure databases

ProteinModelPortaliQ66JY6.
SMRiQ66JY6. Positions 20-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 197176DHPROSITE-ProRule annotationAdd
BLAST
Domaini227 – 331105PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IE9S. Eukaryota.
ENOG4110AJV. LUCA.
GeneTreeiENSGT00440000033863.
HOGENOMiHOG000035112.
HOVERGENiHBG058322.
InParanoidiQ66JY6.
OMAiCPHLELY.
PhylomeDBiQ66JY6.
TreeFamiTF350447.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q66JY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESSGSAACC PVLQQRARWE RKRVCTAREL LETERRYQEQ LGLVATYFLR
60 70 80 90 100
ILKAKGTLRP PELQTLFGTW ELIYAASLEL LPYLEEGQWG LGLQGFCPHL
110 120 130 140 150
ELYAQFAANA ERSQTTLQAQ LKKNKRFRRF VKLQEGRPEF RGLQLQDLLP
160 170 180 190 200
LPLQRLQQYE NLVVALAENT VPNSPDYQQL TRAARLVSET AQKVHAIGQS
210 220 230 240 250
QKNDQHLLRV QALLSGRKAK GLTSGRWFLR QGWLLVVPPT GEPRPRMFFL
260 270 280 290 300
FSDVLLMAKP RPPLHLLKSG TFVCRALYPM SQCHLSRVFG HSGGPCGGLL
310 320 330 340
SLSFPHEKLL LMSTDQEELS QWHHSLTLAI RSQKSSTHRS VTAT
Length:344
Mass (Da):39,106
Last modified:June 26, 2007 - v2
Checksum:iF76359D01A61FB4A
GO
Isoform 2 (identifier: Q66JY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.

Show »
Length:98
Mass (Da):10,937
Checksum:i5A8F474317E317D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601P → L in AAH80700 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 246246Missing in isoform 2. 1 PublicationVSP_026287Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK163287 mRNA. Translation: BAE37276.1.
AL732506 Genomic DNA. Translation: CAM17181.1.
BC080700 mRNA. Translation: AAH80700.1.
CCDSiCCDS18098.1. [Q66JY6-1]
RefSeqiNP_001013395.2. NM_001013377.2. [Q66JY6-1]
XP_006537893.1. XM_006537830.2. [Q66JY6-1]
UniGeneiMm.331567.

Genome annotation databases

EnsembliENSMUST00000054538; ENSMUSP00000055293; ENSMUSG00000051517. [Q66JY6-1]
GeneIDi230098.
KEGGimmu:230098.
UCSCiuc008spz.2. mouse. [Q66JY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK163287 mRNA. Translation: BAE37276.1.
AL732506 Genomic DNA. Translation: CAM17181.1.
BC080700 mRNA. Translation: AAH80700.1.
CCDSiCCDS18098.1. [Q66JY6-1]
RefSeqiNP_001013395.2. NM_001013377.2. [Q66JY6-1]
XP_006537893.1. XM_006537830.2. [Q66JY6-1]
UniGeneiMm.331567.

3D structure databases

ProteinModelPortaliQ66JY6.
SMRiQ66JY6. Positions 20-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ66JY6. 1 interaction.
STRINGi10090.ENSMUSP00000055293.

PTM databases

iPTMnetiQ66JY6.
PhosphoSiteiQ66JY6.

Proteomic databases

EPDiQ66JY6.
PaxDbiQ66JY6.
PRIDEiQ66JY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054538; ENSMUSP00000055293; ENSMUSG00000051517. [Q66JY6-1]
GeneIDi230098.
KEGGimmu:230098.
UCSCiuc008spz.2. mouse. [Q66JY6-1]

Organism-specific databases

CTDi84904.
MGIiMGI:3036286. Arhgef39.

Phylogenomic databases

eggNOGiENOG410IE9S. Eukaryota.
ENOG4110AJV. LUCA.
GeneTreeiENSGT00440000033863.
HOGENOMiHOG000035112.
HOVERGENiHBG058322.
InParanoidiQ66JY6.
OMAiCPHLELY.
PhylomeDBiQ66JY6.
TreeFamiTF350447.

Miscellaneous databases

PROiQ66JY6.
SOURCEiSearch...

Gene expression databases

BgeeiQ66JY6.
CleanExiMM_E130306D19RIK.
ExpressionAtlasiQ66JY6. baseline and differential.
GenevisibleiQ66JY6. MM.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Egg.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Egg.

Entry informationi

Entry nameiARG39_MOUSE
AccessioniPrimary (citable) accession number: Q66JY6
Secondary accession number(s): A2AIN0, Q3TQV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: June 8, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.