Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho guanine nucleotide exchange factor 39

Gene

Arhgef39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 39
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3036286 Arhgef39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918651 – 344Rho guanine nucleotide exchange factor 39Add BLAST344

Proteomic databases

EPDiQ66JY6
PaxDbiQ66JY6
PeptideAtlasiQ66JY6
PRIDEiQ66JY6

PTM databases

iPTMnetiQ66JY6
PhosphoSitePlusiQ66JY6

Expressioni

Gene expression databases

BgeeiENSMUSG00000051517
CleanExiMM_E130306D19RIK
ExpressionAtlasiQ66JY6 baseline and differential
GenevisibleiQ66JY6 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ66JY6, 1 interactor
STRINGi10090.ENSMUSP00000055293

Structurei

3D structure databases

ProteinModelPortaliQ66JY6
SMRiQ66JY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 197DHPROSITE-ProRule annotationAdd BLAST176
Domaini227 – 331PHPROSITE-ProRule annotationAdd BLAST105

Phylogenomic databases

eggNOGiENOG410IE9S Eukaryota
ENOG4110AJV LUCA
GeneTreeiENSGT00440000033863
HOGENOMiHOG000035112
HOVERGENiHBG058322
InParanoidiQ66JY6
OMAiCPHLELY
OrthoDBiEOG091G0DTO
PhylomeDBiQ66JY6
TreeFamiTF350447

Family and domain databases

Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q66JY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESSGSAACC PVLQQRARWE RKRVCTAREL LETERRYQEQ LGLVATYFLR
60 70 80 90 100
ILKAKGTLRP PELQTLFGTW ELIYAASLEL LPYLEEGQWG LGLQGFCPHL
110 120 130 140 150
ELYAQFAANA ERSQTTLQAQ LKKNKRFRRF VKLQEGRPEF RGLQLQDLLP
160 170 180 190 200
LPLQRLQQYE NLVVALAENT VPNSPDYQQL TRAARLVSET AQKVHAIGQS
210 220 230 240 250
QKNDQHLLRV QALLSGRKAK GLTSGRWFLR QGWLLVVPPT GEPRPRMFFL
260 270 280 290 300
FSDVLLMAKP RPPLHLLKSG TFVCRALYPM SQCHLSRVFG HSGGPCGGLL
310 320 330 340
SLSFPHEKLL LMSTDQEELS QWHHSLTLAI RSQKSSTHRS VTAT
Length:344
Mass (Da):39,106
Last modified:June 26, 2007 - v2
Checksum:iF76359D01A61FB4A
GO
Isoform 2 (identifier: Q66JY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.

Show »
Length:98
Mass (Da):10,937
Checksum:i5A8F474317E317D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60P → L in AAH80700 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0262871 – 246Missing in isoform 2. 1 PublicationAdd BLAST246

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK163287 mRNA Translation: BAE37276.1
AL732506 Genomic DNA No translation available.
BC080700 mRNA Translation: AAH80700.1
CCDSiCCDS18098.1 [Q66JY6-1]
RefSeqiNP_001013395.2, NM_001013377.2 [Q66JY6-1]
XP_006537893.1, XM_006537830.3
UniGeneiMm.331567
Mm.362494

Genome annotation databases

EnsembliENSMUST00000054538; ENSMUSP00000055293; ENSMUSG00000051517 [Q66JY6-1]
GeneIDi230098
KEGGimmu:230098
UCSCiuc008spz.2 mouse [Q66JY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARG39_MOUSE
AccessioniPrimary (citable) accession number: Q66JY6
Secondary accession number(s): A2AIN0, Q3TQV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health