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Protein

FGFR1 oncogene partner

Gene

Fgfr1op

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for anchoring microtubules to the centrosomes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
FGFR1 oncogene partner
Gene namesi
Name:Fgfr1op
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1922546. Fgfr1op.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399FGFR1 oncogene partnerPRO_0000233295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei152 – 1521PhosphoserineBy similarity
Modified residuei160 – 1601PhosphoserineBy similarity
Modified residuei170 – 1701PhosphothreonineBy similarity
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei301 – 3011PhosphoserineBy similarity
Modified residuei326 – 3261PhosphoserineBy similarity
Modified residuei337 – 3371PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ66JX5.
PaxDbiQ66JX5.
PeptideAtlasiQ66JX5.
PRIDEiQ66JX5.

PTM databases

iPTMnetiQ66JX5.
PhosphoSiteiQ66JX5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000069135.
CleanExiMM_FGFR1OP.
ExpressionAtlasiQ66JX5. baseline and differential.
GenevisibleiQ66JX5. MM.

Interactioni

Subunit structurei

Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217370. 49 interactions.
IntActiQ66JX5. 51 interactions.
STRINGi10090.ENSMUSP00000095030.

Structurei

3D structure databases

ProteinModelPortaliQ66JX5.
SMRiQ66JX5. Positions 59-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 10233LisHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi196 – 24146Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the FGFR1OP family.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH12. Eukaryota.
ENOG4111J6Y. LUCA.
GeneTreeiENSGT00390000007441.
HOGENOMiHOG000007633.
HOVERGENiHBG081536.
InParanoidiQ66JX5.
KOiK16546.
OMAiYGWRSEP.
OrthoDBiEOG091G0V88.
PhylomeDBiQ66JX5.
TreeFamiTF331893.

Family and domain databases

InterProiIPR018993. FOP_dimerisation-dom_N.
IPR006594. LisH.
[Graphical view]
PfamiPF09398. FOP_dimer. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q66JX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATTAAVVA EEDTELRDLL VQTLENSGVL NRIKAELRAA VFLALEEQEK
60 70 80 90 100
VENKTPLVNE NLKKFLNTKD GRLVASLVAE FLQFFNLDFT LAVFHPETST
110 120 130 140 150
IQGLEGRENL AQDLGIIEAE GTVGGPLLLE VIRRCQQKEK GPASVEGALD
160 170 180 190 200
LSDGHPPSKS PEGKSSANST PSKIPRYKGQ GKKKTIGQKP GDKKTSSETS
210 220 230 240 250
QSEPSVSLSE SKSKSSLHSL AHETRIASFL SSSAVDARDS SALCPDGDDV
260 270 280 290 300
EGDSFFDDPI PKPEKTYGWR AEPRKQVGGL ASLSDKPHLR SGLSSLAGAP
310 320 330 340 350
SLTDPESKRG STVLKDLKLV GEKIGSLGLG TGEDEDYADD FNSASHRSEK
360 370 380 390
SELSIGEEIE EDLSMGVEDG NTSDKLDDLT QDLTVSQLSD VADYLEDVA
Length:399
Mass (Da):42,758
Last modified:October 11, 2004 - v1
Checksum:i9E3219BD4CC729C3
GO
Isoform 2 (identifier: Q66JX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-193: Missing.

Show »
Length:379
Mass (Da):40,549
Checksum:i3F3DFB0A8715BA54
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201L → R in strain: C57BL/6J. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei174 – 19320Missing in isoform 2. 1 PublicationVSP_018122Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028778 mRNA. Translation: BAC26115.1.
AK031261 mRNA. Translation: BAC27326.1.
AK050389 mRNA. Translation: BAC34230.1.
BC080717 mRNA. Translation: AAH80717.1.
BC108331 mRNA. Translation: AAI08332.1.
CCDSiCCDS28380.1. [Q66JX5-2]
CCDS57045.1. [Q66JX5-1]
RefSeqiNP_001183975.1. NM_001197046.1. [Q66JX5-1]
NP_957682.1. NM_201230.5. [Q66JX5-2]
UniGeneiMm.227250.

Genome annotation databases

EnsembliENSMUST00000024636; ENSMUSP00000024636; ENSMUSG00000069135. [Q66JX5-2]
ENSMUST00000097419; ENSMUSP00000095030; ENSMUSG00000069135. [Q66JX5-1]
GeneIDi75296.
KEGGimmu:75296.
UCSCiuc008ajb.2. mouse. [Q66JX5-2]
uc008ajc.2. mouse. [Q66JX5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028778 mRNA. Translation: BAC26115.1.
AK031261 mRNA. Translation: BAC27326.1.
AK050389 mRNA. Translation: BAC34230.1.
BC080717 mRNA. Translation: AAH80717.1.
BC108331 mRNA. Translation: AAI08332.1.
CCDSiCCDS28380.1. [Q66JX5-2]
CCDS57045.1. [Q66JX5-1]
RefSeqiNP_001183975.1. NM_001197046.1. [Q66JX5-1]
NP_957682.1. NM_201230.5. [Q66JX5-2]
UniGeneiMm.227250.

3D structure databases

ProteinModelPortaliQ66JX5.
SMRiQ66JX5. Positions 59-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217370. 49 interactions.
IntActiQ66JX5. 51 interactions.
STRINGi10090.ENSMUSP00000095030.

PTM databases

iPTMnetiQ66JX5.
PhosphoSiteiQ66JX5.

Proteomic databases

MaxQBiQ66JX5.
PaxDbiQ66JX5.
PeptideAtlasiQ66JX5.
PRIDEiQ66JX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024636; ENSMUSP00000024636; ENSMUSG00000069135. [Q66JX5-2]
ENSMUST00000097419; ENSMUSP00000095030; ENSMUSG00000069135. [Q66JX5-1]
GeneIDi75296.
KEGGimmu:75296.
UCSCiuc008ajb.2. mouse. [Q66JX5-2]
uc008ajc.2. mouse. [Q66JX5-1]

Organism-specific databases

CTDi11116.
MGIiMGI:1922546. Fgfr1op.

Phylogenomic databases

eggNOGiENOG410IH12. Eukaryota.
ENOG4111J6Y. LUCA.
GeneTreeiENSGT00390000007441.
HOGENOMiHOG000007633.
HOVERGENiHBG081536.
InParanoidiQ66JX5.
KOiK16546.
OMAiYGWRSEP.
OrthoDBiEOG091G0V88.
PhylomeDBiQ66JX5.
TreeFamiTF331893.

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiQ66JX5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069135.
CleanExiMM_FGFR1OP.
ExpressionAtlasiQ66JX5. baseline and differential.
GenevisibleiQ66JX5. MM.

Family and domain databases

InterProiIPR018993. FOP_dimerisation-dom_N.
IPR006594. LisH.
[Graphical view]
PfamiPF09398. FOP_dimer. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFR1OP_MOUSE
AccessioniPrimary (citable) accession number: Q66JX5
Secondary accession number(s): Q32P17, Q8BH91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.