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Protein

4-hydroxybenzoate polyprenyltransferase, mitochondrial

Gene

Coq2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.UniRule annotation

Catalytic activityi

A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Isoprene biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-2142789. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxybenzoate polyprenyltransferase, mitochondrialUniRule annotation (EC:2.5.1.39UniRule annotation)
Short name:
4-HB polyprenyltransferaseUniRule annotation
Alternative name(s):
Para-hydroxybenzoate--polyprenyltransferaseUniRule annotation
Short name:
PHB:PPTUniRule annotation
Short name:
PHB:polyprenyltransferaseUniRule annotation
Gene namesi
Name:Coq2UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919133. Coq2.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation; Matrix side UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei109 – 12921HelicalUniRule annotationAdd
BLAST
Transmembranei149 – 16921HelicalUniRule annotationAdd
BLAST
Transmembranei173 – 19321HelicalUniRule annotationAdd
BLAST
Transmembranei201 – 22121HelicalUniRule annotationAdd
BLAST
Transmembranei231 – 25121HelicalUniRule annotationAdd
BLAST
Transmembranei278 – 29821HelicalUniRule annotationAdd
BLAST
Transmembranei333 – 35321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of mitochondrial inner membrane Source: UniProtKB-HAMAP
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionUniRule annotationAdd
BLAST
Chaini35 – 3743404-hydroxybenzoate polyprenyltransferase, mitochondrialUniRule annotationPRO_0000228624Add
BLAST

Proteomic databases

PaxDbiQ66JT7.
PRIDEiQ66JT7.

PTM databases

PhosphoSiteiQ66JT7.

Expressioni

Gene expression databases

BgeeiQ66JT7.
CleanExiMM_COQ2.
ExpressionAtlasiQ66JT7. baseline and differential.
GenevisibleiQ66JT7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031262.

Structurei

3D structure databases

ProteinModelPortaliQ66JT7.
SMRiQ66JT7. Positions 114-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 14423Allylic polyprenyl diphosphate-binding siteUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.UniRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1381. Eukaryota.
COG0382. LUCA.
GeneTreeiENSGT00390000006862.
HOGENOMiHOG000003697.
HOVERGENiHBG081302.
InParanoidiQ66JT7.
KOiK06125.
OMAiIPMAFMA.
OrthoDBiEOG72VH75.
TreeFamiTF105873.

Family and domain databases

HAMAPiMF_01635. UbiA.
InterProiIPR031103. HB_octoprenylTrfase.
IPR006370. HB_polyprenyltransferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66JT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWGGAGLA RGLRAVRSAW LRGPRGLPLA LVRSAGVPGA RDRRAPAPGT
60 70 80 90 100
QRGRALSLSA AAVVNSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA
110 120 130 140 150
ADPGCFPDWY MLSLFGTGAI LMRGAGCTIN DMWDRDFDKK VTRTANRPIA
160 170 180 190 200
AGDISTFQSF VFLGGQLTLA LGVLLCLNYY SIAMGAASLL LVVTYPLVKR
210 220 230 240 250
ITFWPQLALG LTFNWGALLG WSAVKGSCDP AVCLPLYFSG VMWTLIYDTI
260 270 280 290 300
YAHQDKKDDA LIGLKSTALL FQENTRQWLS GFGVAMVAAL SLAGANNGQT
310 320 330 340 350
VPYYAAVAAV GAHLAHQIYT VDIHRAEDCW DKFTSNRTVG MLLFLGIVLG
360 370
NLCKEKTEEA KDAEAVRVGS EQTS
Length:374
Mass (Da):40,504
Last modified:July 27, 2011 - v2
Checksum:iAD9E9B2644B5501B
GO

Sequence cautioni

The sequence BAB26064.1 differs from that shown. Reason: Erroneous termination at position 303. Translated as Tyr.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981V → M in AAH80773 (PubMed:15489334).Curated
Sequence conflicti297 – 2971N → S in AAH80773 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009092 mRNA. Translation: BAB26064.1. Sequence problems.
AC109196 Genomic DNA. No translation available.
AC161510 Genomic DNA. No translation available.
BC080773 mRNA. Translation: AAH80773.1.
CCDSiCCDS19465.1.
RefSeqiNP_082254.2. NM_027978.2.
UniGeneiMm.260661.

Genome annotation databases

EnsembliENSMUST00000031262; ENSMUSP00000031262; ENSMUSG00000029319.
GeneIDi71883.
KEGGimmu:71883.
UCSCiuc008yhu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009092 mRNA. Translation: BAB26064.1. Sequence problems.
AC109196 Genomic DNA. No translation available.
AC161510 Genomic DNA. No translation available.
BC080773 mRNA. Translation: AAH80773.1.
CCDSiCCDS19465.1.
RefSeqiNP_082254.2. NM_027978.2.
UniGeneiMm.260661.

3D structure databases

ProteinModelPortaliQ66JT7.
SMRiQ66JT7. Positions 114-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031262.

PTM databases

PhosphoSiteiQ66JT7.

Proteomic databases

PaxDbiQ66JT7.
PRIDEiQ66JT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031262; ENSMUSP00000031262; ENSMUSG00000029319.
GeneIDi71883.
KEGGimmu:71883.
UCSCiuc008yhu.2. mouse.

Organism-specific databases

CTDi27235.
MGIiMGI:1919133. Coq2.

Phylogenomic databases

eggNOGiKOG1381. Eukaryota.
COG0382. LUCA.
GeneTreeiENSGT00390000006862.
HOGENOMiHOG000003697.
HOVERGENiHBG081302.
InParanoidiQ66JT7.
KOiK06125.
OMAiIPMAFMA.
OrthoDBiEOG72VH75.
TreeFamiTF105873.

Enzyme and pathway databases

UniPathwayiUPA00232.
ReactomeiR-MMU-2142789. Ubiquinol biosynthesis.

Miscellaneous databases

PROiQ66JT7.
SOURCEiSearch...

Gene expression databases

BgeeiQ66JT7.
CleanExiMM_COQ2.
ExpressionAtlasiQ66JT7. baseline and differential.
GenevisibleiQ66JT7. MM.

Family and domain databases

HAMAPiMF_01635. UbiA.
InterProiIPR031103. HB_octoprenylTrfase.
IPR006370. HB_polyprenyltransferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Jaw and Limb.

Entry informationi

Entry nameiCOQ2_MOUSE
AccessioniPrimary (citable) accession number: Q66JT7
Secondary accession number(s): E9QPH1, Q9D7M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.