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Protein

Tubulin polyglutamylase complex subunit 2

Gene

Tpgs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polyglutamylase complex subunit 2
Short name:
PGs2
Gene namesi
Name:Tpgs2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913898. Tpgs2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Tubulin polyglutamylase complex subunit 2PRO_0000079305Add
BLAST

Proteomic databases

MaxQBiQ66JT5.
PaxDbiQ66JT5.
PRIDEiQ66JT5.

PTM databases

PhosphoSiteiQ66JT5.

Expressioni

Gene expression databases

CleanExiMM_5730494M16RIK.

Interactioni

Subunit structurei

Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IJVC. Eukaryota.
ENOG4111HTQ. LUCA.
HOGENOMiHOG000294114.
HOVERGENiHBG073636.
InParanoidiQ66JT5.
KOiK16605.
PhylomeDBiQ66JT5.

Family and domain databases

InterProiIPR018958. SMI1/KNR4-like_dom.
[Graphical view]
SMARTiSM00860. SMI1_KNR4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66JT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEETTPPLQA GSKPHLEKLT LGVTRILESS PGVTEVSIIE KLPAERHVIS
60 70 80 90 100
SWEQKNNCVM PEDVRNFYLM TNGFHMTWSV KLDEHIIPLG SMVINGISKL
110 120 130 140 150
TQLIQSSVYS LPNAPTLADL EDDTQEGNED HQLEKPHFDC RSAIFELDSC
160 170 180 190 200
NGNGKVCLVY KNGKPGLAHD TEIWFLDRAL YWHFLTDTFI AYYRLLITHL
210 220 230 240 250
GLPQWQYAFT SYGISPQAKQ WFSMYKPITY NTSLLTEESD NFANKLDPSK
260 270 280 290
VFKSKNKILI PKKKGPVPPA SGQKGPGPLP PPTSKPTTGS GNPVRK
Length:296
Mass (Da):33,184
Last modified:September 5, 2006 - v2
Checksum:i0BEAAB6C4A84B376
GO

Sequence cautioni

The sequence AAH80777.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901I → T in AAH60253 (PubMed:15489334).Curated
Sequence conflicti243 – 2431A → V in AAH60253 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060253 mRNA. Translation: AAH60253.1.
BC080777 mRNA. Translation: AAH80777.1. Different initiation.
CCDSiCCDS29105.2.
RefSeqiNP_001004361.2. NM_001004361.2.
NP_001136170.1. NM_001142698.1.
UniGeneiMm.263189.
Mm.441171.

Genome annotation databases

GeneIDi66648.
KEGGimmu:66648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060253 mRNA. Translation: AAH60253.1.
BC080777 mRNA. Translation: AAH80777.1. Different initiation.
CCDSiCCDS29105.2.
RefSeqiNP_001004361.2. NM_001004361.2.
NP_001136170.1. NM_001142698.1.
UniGeneiMm.263189.
Mm.441171.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ66JT5.

Proteomic databases

MaxQBiQ66JT5.
PaxDbiQ66JT5.
PRIDEiQ66JT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi66648.
KEGGimmu:66648.

Organism-specific databases

CTDi25941.
MGIiMGI:1913898. Tpgs2.

Phylogenomic databases

eggNOGiENOG410IJVC. Eukaryota.
ENOG4111HTQ. LUCA.
HOGENOMiHOG000294114.
HOVERGENiHBG073636.
InParanoidiQ66JT5.
KOiK16605.
PhylomeDBiQ66JT5.

Miscellaneous databases

PROiQ66JT5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_5730494M16RIK.

Family and domain databases

InterProiIPR018958. SMI1/KNR4-like_dom.
[Graphical view]
SMARTiSM00860. SMI1_KNR4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Embryo.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY AS PART OF THE TUBULIN POLYGLUTAMYLASE COMPLEX.

Entry informationi

Entry nameiTPGS2_MOUSE
AccessioniPrimary (citable) accession number: Q66JT5
Secondary accession number(s): Q6PAK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.